{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A2ALV5","uniProtkbId":"SHOC1_MOUSE","entryAudit":{"firstPublicDate":"2018-07-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-20","entryVersion":106,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein shortage in chiasmata 1 ortholog"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5VXU9"}],"value":"3.6.-.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30272023"}],"value":"Protein ZIP2 homolog"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30272023"}],"value":"MZip2"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29742103"}],"value":"Shoc1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30272023"}],"value":"Zip2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5VXU9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30272023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35485979"}],"value":"ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). 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Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1 (PubMed:29742103)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30272023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30746471"}],"value":"Chromosome","id":"SL-0468"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30272023"}],"value":"Mainly expressed in adult testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30272023"}],"value":"Expressed in embryonic ovaries at embryonic day 16.5"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30272023"}],"value":"Mice show severe defects in meiotic prophase I, such as DNA double-strand break (DSB) repair, crossover formation and synapsis in spermatocytes and oocytes resulting in sterility in both male and females (PubMed:30272023). Embryonic lethality due to defects in meiosis (PubMed:29742103). The use of a hypomorphic allele showed that spermatogenesis progresses normally until the end of prophase I when spermatocytes arrest at metaphase I: homologous chromosomes pair in spermatocytes but show defective synapsis (PubMed:29742103)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the XPF family. 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