{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A2A8L1","secondaryAccessions":["Q6ZQB2"],"uniProtkbId":"CHD5_MOUSE","entryAudit":{"firstPublicDate":"2014-06-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-20","entryVersion":143,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"ATP-dependent chromatin remodeler CHD5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q12873"}],"value":"3.6.4.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Chromo domain-containing protein 5"},"shortNames":[{"value":"CHD-5"}]}]},"genes":[{"geneName":{"value":"Chd5"},"synonyms":[{"value":"Kiaa0444"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23948251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24252660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27806305"}],"value":"ATP-dependent chromatin-remodeling factor that binds DNA through histones and regulates gene transcription (PubMed:23318260). May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 (PubMed:23318260, PubMed:23948251). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:27806305). Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation (PubMed:23948251, PubMed:27806305). In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages (PubMed:23948251). Regulates the expression of genes involved in cell proliferation and differentiation (PubMed:17289567). Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation (PubMed:17289567). In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa (PubMed:24252660)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q12873"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21931736"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27806305"}],"value":"Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:21931736, PubMed:27806305). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:27806305). Interacts with HDAC2 (PubMed:27806305)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23948251"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27806305"}],"value":"Chromosome","id":"SL-0468"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21931736"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23948251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24252660"}],"value":"Specifically expressed by neurons in brain, retina and adrenal gland (at protein level). Also detected in testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21931736"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23948251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27806305"}],"value":"Detected at 15.5 dpc in the cortex, expression increases at 18.5 dpc, after birth and to adulthood. Expression increases in late-stage neuronal progenitor during their terminal differentiation"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"value":"The PHD domains mediate specific binding to histone H3 unmethylated at 'Lys-4' and may preferentially recruit the protein to transcriptionally inactive genes"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23948251"}],"value":"The chromo domains mediate specific binding to histone H3 trimethylated at 'Lys-27' (H3K27me3) and may be required in neuron differentiation for proper gene regulation"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TDI0"}],"value":"Methylated at Gln-1392 by N6AMT1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24252660"}],"value":"Mutant males are infertile. Mating occurs, but the males are sterile, displaying abnormal spermatogenesis. Disruption of the gene has no effect on the fertility of females. Infertility is due to sperm morphological abnormalities and complete immotility that are observed in all mice. A variable sperm counts, with a complete absence is some individuals is also observed. Spermatogenesis is normal from spermatogonia through meiotic division of spermatocytes. However, at stage IX, step 9, abnormal nuclear morphology of differentiating spermatids appears. It is associated with increased histone retention and decreased histone H4 hyperacetylation, an important step in spermatid chromatid condensation. Finally, spermiation is also affected"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SNF2/RAD54 helicase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1946,"modifier":"EXACT"}},"description":"ATP-dependent chromatin remodeler CHD5","featureId":"PRO_0000429326"},{"type":"Domain","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"Chromo 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00053"}]},{"type":"Domain","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"Chromo 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00053"}]},{"type":"Domain","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":898,"modifier":"EXACT"}},"description":"Helicase ATP-binding","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00541"}]},{"type":"Domain","location":{"start":{"value":1030,"modifier":"EXACT"},"end":{"value":1195,"modifier":"EXACT"}},"description":"Helicase C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00542"}]},{"type":"Zinc finger","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"PHD-type 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00146"}]},{"type":"Zinc finger","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"PHD-type 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00146"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"Histone-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":551,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1210,"modifier":"EXACT"},"end":{"value":1254,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1353,"modifier":"EXACT"},"end":{"value":1413,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1525,"modifier":"EXACT"},"end":{"value":1566,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1579,"modifier":"EXACT"},"end":{"value":1696,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1926,"modifier":"EXACT"},"end":{"value":1946,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":849,"modifier":"EXACT"},"end":{"value":852,"modifier":"EXACT"}},"description":"DEAH box"},{"type":"Compositional bias","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1212,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1357,"modifier":"EXACT"},"end":{"value":1368,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1387,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1551,"modifier":"EXACT"},"end":{"value":1564,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1602,"modifier":"EXACT"},"end":{"value":1629,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1637,"modifier":"EXACT"},"end":{"value":1654,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1661,"modifier":"EXACT"},"end":{"value":1676,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":727,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00541"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":1392,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"N5-methylglutamine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TDI0"}]},{"type":"Modified residue","location":{"start":{"value":1556,"modifier":"EXACT"},"end":{"value":1556,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Mutagenesis","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"No effect on interaction with histone H3 unmethylated at 'Lys-4'. No significant effect on the ability to repress target genes expression. No effect on regulation of cell proliferation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Loss of the ability to negatively regulate cell proliferation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Loss of interaction with histone H3 unmethylated at 'Lys-4'. Loss of the ability to repress target genes expression. Loss of the ability to negatively regulate cell proliferation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"Loss of interaction with histone H3 unmethylated at 'Lys-4'. Loss of the ability to negatively regulate cell proliferation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Loss of the ability to negatively regulate cell proliferation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"Loss of interaction with histone H3 unmethylated at 'Lys-4'. Loss of the ability to repress target genes expression. Loss of the ability to negatively regulate cell proliferation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23318260"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0744","category":"Biological process","name":"Spermatogenesis"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0043","category":"Disease","name":"Tumor suppressor"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"14621295","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Koseki H.","Hiraoka S.","Saga Y.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"14621295"},{"database":"DOI","id":"10.1093/dnares/10.4.167"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"167","lastPage":"180","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1245-1946"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"17289567","citationType":"journal article","authors":["Bagchi A.","Papazoglu C.","Wu Y.","Capurso D.","Brodt M.","Francis D.","Bredel M.","Vogel H.","Mills A.A."],"citationCrossReferences":[{"database":"PubMed","id":"17289567"},{"database":"DOI","id":"10.1016/j.cell.2006.11.052"}],"title":"CHD5 is a tumor suppressor at human 1p36.","publicationDate":"2007","journal":"Cell","firstPage":"459","lastPage":"475","volume":"128"},"referencePositions":["FUNCTION IN CELL PROLIFERATION"]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1556","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21931736","citationType":"journal article","authors":["Potts R.C.","Zhang P.","Wurster A.L.","Precht P.","Mughal M.R.","Wood W.H.","Zhang Y.","Becker K.G.","Mattson M.P.","Pazin M.J."],"citationCrossReferences":[{"database":"PubMed","id":"21931736"},{"database":"DOI","id":"10.1371/journal.pone.0024515"}],"title":"CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E24515","lastPage":"E24515","volume":"6"},"referencePositions":["IDENTIFICATION IN THE NURD COMPLEX","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]},{"referenceNumber":6,"citation":{"id":"23318260","citationType":"journal article","authors":["Paul S.","Kuo A.","Schalch T.","Vogel H.","Joshua-Tor L.","McCombie W.R.","Gozani O.","Hammell M.","Mills A.A."],"citationCrossReferences":[{"database":"PubMed","id":"23318260"},{"database":"DOI","id":"10.1016/j.celrep.2012.12.009"}],"title":"Chd5 requires PHD-mediated histone 3 binding for tumor suppression.","publicationDate":"2013","journal":"Cell Rep.","firstPage":"92","lastPage":"102","volume":"3"},"referencePositions":["FUNCTION IN TRANSCRIPTION","UNMETHYLATED HISTONE H3K4-BINDING","PHD DOMAINS","SUBCELLULAR LOCATION","MUTAGENESIS OF ASP-346; GLY-355; ASP-361; ASP-415; CYS-432 AND ASP-434"]},{"referenceNumber":7,"citation":{"id":"23948251","citationType":"journal article","authors":["Egan C.M.","Nyman U.","Skotte J.","Streubel G.","Turner S.","O'Connell D.J.","Rraklli V.","Dolan M.J.","Chadderton N.","Hansen K.","Farrar G.J.","Helin K.","Holmberg J.","Bracken A.P."],"citationCrossReferences":[{"database":"PubMed","id":"23948251"},{"database":"DOI","id":"10.1016/j.devcel.2013.07.008"}],"title":"CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.","publicationDate":"2013","journal":"Dev. Cell","firstPage":"223","lastPage":"236","volume":"26"},"referencePositions":["FUNCTION IN NEURON DIFFERENTIATION","HISTONE H3K27ME3-BINDING","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]},{"referenceNumber":8,"citation":{"id":"24252660","citationType":"journal article","authors":["Zhuang T.","Hess R.A.","Kolla V.","Higashi M.","Raabe T.D.","Brodeur G.M."],"citationCrossReferences":[{"database":"PubMed","id":"24252660"},{"database":"DOI","id":"10.1016/j.mod.2013.10.005"}],"title":"CHD5 is required for spermiogenesis and chromatin condensation.","publicationDate":"2014","journal":"Mech. Dev.","firstPage":"35","lastPage":"46","volume":"131"},"referencePositions":["FUNCTION IN SPERMATOGENESIS","DISRUPTION PHENOTYPE","TISSUE SPECIFICITY"]},{"referenceNumber":9,"citation":{"id":"27806305","citationType":"journal article","authors":["Nitarska J.","Smith J.G.","Sherlock W.T.","Hillege M.M.","Nott A.","Barshop W.D.","Vashisht A.A.","Wohlschlegel J.A.","Mitter R.","Riccio A."],"citationCrossReferences":[{"database":"PubMed","id":"27806305"},{"database":"DOI","id":"10.1016/j.celrep.2016.10.022"}],"title":"A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.","publicationDate":"2016","journal":"Cell Rep.","firstPage":"1683","lastPage":"1698","volume":"17"},"referencePositions":["FUNCTION","IDENTIFICATION IN THE NURD COMPLEX","INTERACTION WITH HDAC2","IDENTIFICATION BY MASS SPECTROMETRY","SUBCELLULAR LOCATION","DEVELOPMENTAL STAGE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL611985","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK129145","properties":[{"key":"ProteinId","value":"BAC97955.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS89866.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001356172.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001369243.1"}]},{"database":"AlphaFoldDB","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"234678","properties":[{"key":"Interactions","value":"13"}]},{"database":"FunCoup","id":"A2A8L1","properties":[{"key":"Number of interactors","value":"1086"}]},{"database":"IntAct","id":"A2A8L1","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"10090.ENSMUSP00000030775","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A2A8L1","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000030775","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"281603","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27125","properties":[{"key":"antibodies","value":"140 antibodies from 30 providers"}]},{"database":"Ensembl","id":"ENSMUST00000005175.5","properties":[{"key":"ProteinId","value":"ENSMUSP00000005175.5"},{"key":"GeneId","value":"ENSMUSG00000005045.17"}]},{"database":"GeneID","id":"269610","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:269610","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"MGI:3036258","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"26038","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:3036258","properties":[{"key":"GeneName","value":"Chd5"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000005045","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0383","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159249","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5857104at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-9937850","properties":[{"key":"PathwayName","value":"NuRD complex assembly"}]},{"database":"Reactome","id":"R-MMU-9940951","properties":[{"key":"PathwayName","value":"Interaction of NuRD complexes with transcription factors"}]},{"database":"BioGRID-ORCS","id":"269610","properties":[{"key":"hits","value":"6 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:A2A8L1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"A2A8L1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000005045","properties":[{"key":"ExpressionPatterns","value":"Expressed in subiculum and 115 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A2A8L1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27806305"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000792","properties":[{"key":"GoTerm","value":"C:heterochromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23318260"}]},{"database":"GO","id":"GO:0016607","properties":[{"key":"GoTerm","value":"C:nuclear speck"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23948251"}]},{"database":"GO","id":"GO:0016581","properties":[{"key":"GoTerm","value":"C:NuRD complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21931736"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0140658","properties":[{"key":"GoTerm","value":"F:ATP-dependent chromatin remodeler activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042393","properties":[{"key":"GoTerm","value":"F:histone binding"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23318260"}]},{"database":"GO","id":"GO:0042826","properties":[{"key":"GoTerm","value":"F:histone deacetylase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21931736"}]},{"database":"GO","id":"GO:0061628","properties":[{"key":"GoTerm","value":"F:histone H3K27me3 reader activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23948251"}]},{"database":"GO","id":"GO:0021895","properties":[{"key":"GoTerm","value":"P:cerebral cortex neuron differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23948251"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17289567"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23318260"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IMP:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23318260"}]},{"database":"GO","id":"GO:1901798","properties":[{"key":"GoTerm","value":"P:positive regulation of signal transduction by p53 class mediator"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17289567"}]},{"database":"GO","id":"GO:0045595","properties":[{"key":"GoTerm","value":"P:regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23318260"}]},{"database":"GO","id":"GO:0035092","properties":[{"key":"GoTerm","value":"P:sperm DNA condensation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24252660"}]},{"database":"GO","id":"GO:0006366","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd18667","properties":[{"key":"EntryName","value":"CD1_tandem_CHD3-4_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18662","properties":[{"key":"EntryName","value":"CD2_tandem_CHD3-4_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18057","properties":[{"key":"EntryName","value":"DEXHc_CHD5"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd15531","properties":[{"key":"EntryName","value":"PHD1_CHD_II"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd15532","properties":[{"key":"EntryName","value":"PHD2_CHD_II"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18793","properties":[{"key":"EntryName","value":"SF2_C_SNF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000037","properties":[{"key":"EntryName","value":"chromodomain-helicase-DNA-binding protein 3 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.40:FF:000003","properties":[{"key":"EntryName","value":"chromodomain-helicase-DNA-binding protein 3 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000001","properties":[{"key":"EntryName","value":"chromodomain-helicase-DNA-binding protein 3 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.10810:FF:000001","properties":[{"key":"EntryName","value":"chromodomain-helicase-DNA-binding protein 3 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000011","properties":[{"key":"EntryName","value":"chromodomain-helicase-DNA-binding protein 4 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000015","properties":[{"key":"EntryName","value":"chromodomain-helicase-DNA-binding protein 9 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10810","properties":[{"key":"EntryName","value":"Tandem AAA-ATPase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR012957","properties":[{"key":"EntryName","value":"CHD_C2"}]},{"database":"InterPro","id":"IPR009462","properties":[{"key":"EntryName","value":"CHD_II_SANT-like"}]},{"database":"InterPro","id":"IPR012958","properties":[{"key":"EntryName","value":"CHD_N"}]},{"database":"InterPro","id":"IPR016197","properties":[{"key":"EntryName","value":"Chromo-like_dom_sf"}]},{"database":"InterPro","id":"IPR000953","properties":[{"key":"EntryName","value":"Chromo/chromo_shadow_dom"}]},{"database":"InterPro","id":"IPR023780","properties":[{"key":"EntryName","value":"Chromo_domain"}]},{"database":"InterPro","id":"IPR028727","properties":[{"key":"EntryName","value":"DEXHc_CHD5"}]},{"database":"InterPro","id":"IPR002464","properties":[{"key":"EntryName","value":"DNA/RNA_helicase_DEAH_CS"}]},{"database":"InterPro","id":"IPR009463","properties":[{"key":"EntryName","value":"DUF1087"}]},{"database":"InterPro","id":"IPR014001","properties":[{"key":"EntryName","value":"Helicase_ATP-bd"}]},{"database":"InterPro","id":"IPR001650","properties":[{"key":"EntryName","value":"Helicase_C-like"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR038718","properties":[{"key":"EntryName","value":"SNF2-like_sf"}]},{"database":"InterPro","id":"IPR049730","properties":[{"key":"EntryName","value":"SNF2/RAD54-like_C"}]},{"database":"InterPro","id":"IPR000330","properties":[{"key":"EntryName","value":"SNF2_N"}]},{"database":"InterPro","id":"IPR019786","properties":[{"key":"EntryName","value":"Zinc_finger_PHD-type_CS"}]},{"database":"InterPro","id":"IPR011011","properties":[{"key":"EntryName","value":"Znf_FYVE_PHD"}]},{"database":"InterPro","id":"IPR001965","properties":[{"key":"EntryName","value":"Znf_PHD"}]},{"database":"InterPro","id":"IPR019787","properties":[{"key":"EntryName","value":"Znf_PHD-finger"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"PANTHER","id":"PTHR45623","properties":[{"key":"EntryName","value":"CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45623:SF6","properties":[{"key":"EntryName","value":"CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08074","properties":[{"key":"EntryName","value":"CHDCT2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06461","properties":[{"key":"EntryName","value":"CHDII_SANT-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08073","properties":[{"key":"EntryName","value":"CHDNT"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00385","properties":[{"key":"EntryName","value":"Chromo"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06465","properties":[{"key":"EntryName","value":"DUF1087"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00271","properties":[{"key":"EntryName","value":"Helicase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00628","properties":[{"key":"EntryName","value":"PHD"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00176","properties":[{"key":"EntryName","value":"SNF2-rel_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00298","properties":[{"key":"EntryName","value":"CHROMO"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00487","properties":[{"key":"EntryName","value":"DEXDc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01146","properties":[{"key":"EntryName","value":"DUF1086"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01147","properties":[{"key":"EntryName","value":"DUF1087"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00490","properties":[{"key":"EntryName","value":"HELICc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00249","properties":[{"key":"EntryName","value":"PHD"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF54160","properties":[{"key":"EntryName","value":"Chromo domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF57903","properties":[{"key":"EntryName","value":"FYVE/PHD zinc finger"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50013","properties":[{"key":"EntryName","value":"CHROMO_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00690","properties":[{"key":"EntryName","value":"DEAH_ATP_HELICASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51192","properties":[{"key":"EntryName","value":"HELICASE_ATP_BIND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51194","properties":[{"key":"EntryName","value":"HELICASE_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01359","properties":[{"key":"EntryName","value":"ZF_PHD_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50016","properties":[{"key":"EntryName","value":"ZF_PHD_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDPKTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQTSSRRRDFPLFQRSFPAEPSHLPNPRGREKLQPF","length":1946,"molWeight":222515,"crc64":"5B94AB11A9C9BB03","md5":"D3E24FDCCBBAC523FC7E7E142D31619F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":2,"PTM":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":4,"Zinc finger":2,"Region":10,"Motif":1,"Compositional bias":14,"Binding site":1,"Modified residue":2,"Mutagenesis":6},"uniParcId":"UPI000059E25E"}}