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Involved in mitotic spindle assembly (PubMed:17412918, PubMed:26246606). Regulates microtubule (MT) severing (PubMed:17412918). Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation (PubMed:20946984, PubMed:24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188). In fat body cells, part of perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) which function to accommodate the organization of microtubule (MT) networks to control nuclear positioning and dynein motor-based retrograde endosomal trafficking (PubMed:32066907). Within the ncMTOC, Msp300 and shot anchors the ncMTOC at the nuclear surface and recruits the MT minus-end regulators Patronin and Nin for assembly, anchoring and/or stabilization of circumferential and radial MTs at the ncMTOCs (PubMed:32066907). This protein, and perhaps Nin, recruits msps to the ncMTOC for the gamma-tubulin-independent elongation of radial MTs (PubMed:32066907)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20946984"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32066907"}],"value":"Interacts with msps (PubMed:32066907). Associates with the minus end of the microtubules (PubMed:20946984)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20946984"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32066907"}],"value":"Localizes to centrosomes in prophase, to the midbody during cytokinesis, diffusely throughout the metaphase spindle and to punctae in interphase that often overlap with MTs (PubMed:20946984). Colocalizes with Sas-4 and SAK at the microtubule organizing center (MTOC) (PubMed:20946984). In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) (PubMed:32066907)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24100293"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body","id":"SL-0252"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20946984"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32066907"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center","id":"SL-0484"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32066907"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"C"},"isoformIds":["A1ZAU8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"A"},"isoformIds":["A1ZAU8-2"],"sequenceIds":["VSP_037213","VSP_037214","VSP_037215"],"isoformSequenceStatus":"Described"},{"name":{"value":"B"},"isoformIds":["A1ZAU8-3"],"sequenceIds":["VSP_037213","VSP_037214","VSP_037216"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00841"}],"value":"The CKK domain binds microtubules"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32066907"}],"value":"RNAi-mediated knockdown reduces circumferential microtubules (MTs) in fat body cells and reduces msps recruitment to the nuclear membrane (PubMed:32066907). No effect on the radial MTs or nuclear positioning (PubMed:32066907). However, simultaneous knockdown of Nin and Patronin, impairs both radial and circumferential MT assembly resulting in defective nuclear positioning (PubMed:32066907). Simultaneous knockdown with Nin, also results in a further decrease in msps recruitment to the nuclear membrane (PubMed:32066907)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00841"}],"value":"Belongs to the CAMSAP1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAM49943.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1630,"modifier":"EXACT"}},"description":"Patronin","featureId":"PRO_0000372861"},{"type":"Domain","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Calponin-homology 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LOCATION":1,"ALTERNATIVE PRODUCTS":3,"DOMAIN":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":2,"Region":10,"Coiled coil":2,"Compositional bias":22,"Modified residue":21,"Alternative sequence":4,"Sequence conflict":3},"uniParcId":"UPI000034E050"}}