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Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks (PubMed:30260959, PubMed:30567930). Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity (PubMed:30567930). Not involved in assembly of the embryonic basement membrane (PubMed:30567930)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30260959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30567930"}],"value":"Secreted in the hemolymph (PubMed:30260959). 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At stage 11/12, embeds dorsal median cells and somatic myoblasts forming a thin layer between the ectoderm and the mesoderm and around the prospective anal plate (PubMed:30567930). At stage 12, after germ band retraction, accumulates in the forming basal membranes around the developing brain and ventral nerve cord, in the differentiating tracheal system, in the future digestive tract as well as in the forming somatic muscles (PubMed:30567930). At stage 13, accumulates around caudal visceral mesodermal cells (PubMed:30260959). At stage 16, expressed in the basal membrane surrounding most tissues, including muscles, gut and larval ventral nerve cord, brain, and in chordotonal organs (at protein level) (PubMed:30260959, PubMed:30567930). Expressed in embryonic macrophages (at protein level) (PubMed:30260959). In the larva, expressed mainly by fat body adipocytes and blood cells in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level) (PubMed:30260959). Expressed during embryogenesis: at stage 11/12 detected in single cells of the head, especially in the gnathal segments as well as in segmentally located patches of cells in the dorsal mesoderm, detected in the midline-associated, mesodermal dorsal median cells and somatic myoblasts (PubMed:30567930). Only low expression in the amnioserosa (PubMed:30567930). After germ band retraction (stage 12), expressed in the forming dorsal and ventral muscles, the amnioserosa and the segmentally located chordotonal organs (PubMed:30567930). Expressed in the esophageal visceral muscle primordium and in the joint region between hind- and midgut (PubMed:30567930). At stage 16, expressed in somatic and visceral muscles, and in the cap cells of the chordotonal organs (PubMed:30567930)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30260959"}],"value":"The NIDO domain (also known as globular region 1 or G1) contributes to the localization to the basal membrane probably by binding to vkg"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30260959"}],"value":"The EGF-like 1 and nidogen G2 beta-barrel domain (also known as globular region 2 or G2) contribute to the localization to the basal membrane probably by binding to vkg"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30260959"}],"value":"The EGF-like 2-8 domains (also known as the ROD domain) is necessary but not sufficient for localization to the basal membrane"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30260959"}],"value":"The LDL-receptor class B 1-4 domains (also known as globular region 3 or G3) is necessary for cell-extracellular matrix (ECM) interactions. 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Increases neuromuscular junction (NMJ) size including abnormal branching numbers, overall branch length and enhanced bouton density suggesting defective NMJ maturation (PubMed:30567930). Reduces reaction to vibrational stimuli with partial loss of alignment of sensory cilia and morphological defects of the larval peripheral nervous system (PubMed:30567930). Results in smaller pupae presenting an orientation shift of the pupal cases towards the horizontal axis (PubMed:30567930). Results in incompletely inflated wing blades in a small group of adults (PubMed:30567930)"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"Nidogen","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_5015085945"},{"type":"Domain","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"NIDO","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00570"}]},{"type":"Domain","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"EGF-like 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