{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A1YIY0","secondaryAccessions":["E9QM04"],"uniProtkbId":"FCRL6_MOUSE","entryAudit":{"firstPublicDate":"2007-03-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-10-16","entryVersion":109,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Fc receptor-like protein 6"},"shortNames":[{"value":"FcR-like protein 6"},{"value":"FcRL6"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"Fcrl6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6DN72"}],"value":"Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an Fc receptor"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6DN72"}],"value":"Interacts with class II MHC"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6DN72"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["A1YIY0-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["A1YIY0-2"],"sequenceIds":["VSP_053295","VSP_053296"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Fc receptor-like protein 6","featureId":"PRO_0000280214"},{"type":"Topological domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"Ig-like C2-type"},{"type":"Glycosylation","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"}]},{"type":"Alternative sequence","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17213291"}],"featureId":"VSP_053295","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Alternative sequence","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17213291"}],"featureId":"VSP_053296","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"in Ref. 1; ABL86186","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"17213291","citationType":"journal article","authors":["Wilson T.J.","Presti R.M.","Tassi I.","Overton E.T.","Cella M.","Colonna M."],"citationCrossReferences":[{"database":"PubMed","id":"17213291"},{"database":"DOI","id":"10.1182/blood-2006-06-030023"}],"title":"FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.","publicationDate":"2007","journal":"Blood","firstPage":"3786","lastPage":"3793","volume":"109"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF032497","properties":[{"key":"ProteinId","value":"ABL86186.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC131177","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS48448.1","properties":[{"key":"Description","value":"-"}],"isoformId":"A1YIY0-1"},{"database":"RefSeq","id":"NP_001158197.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001164725.1"}],"isoformId":"A1YIY0-1"},{"database":"AlphaFoldDB","id":"A1YIY0","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A1YIY0","properties":[{"key":"Number of interactors","value":"178"}]},{"database":"STRING","id":"10090.ENSMUSP00000091861","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"A1YIY0","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"A1YIY0","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"A1YIY0","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"A1YIY0","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000091861","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"47058","properties":[{"key":"antibodies","value":"84 antibodies from 14 providers"}]},{"database":"Ensembl","id":"ENSMUST00000094303.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000091861.5"},{"key":"GeneId","value":"ENSMUSG00000070504.10"}],"isoformId":"A1YIY0-1"},{"database":"GeneID","id":"677296","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:677296","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc011wwo.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"A1YIY0-1"},{"database":"AGR","id":"MGI:3618339","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"343413","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:3618339","properties":[{"key":"GeneName","value":"Fcrl6"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000070504","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RU0I","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244808","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_023383_5_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A1YIY0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YACEISA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9950534at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"A1YIY0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"677296","properties":[{"key":"hits","value":"1 hit in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:A1YIY0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"A1YIY0","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000070504","properties":[{"key":"ExpressionPatterns","value":"Expressed in mesodermal cell in embryo and 9 other cell types or tissues"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17213291"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042289","properties":[{"key":"GoTerm","value":"F:MHC class II protein binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019902","properties":[{"key":"GoTerm","value":"F:phosphatase binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019903","properties":[{"key":"GoTerm","value":"F:protein phosphatase binding"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17213291"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"2.60.40.10:FF:000357","properties":[{"key":"EntryName","value":"Fc receptor like 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR050488","properties":[{"key":"EntryName","value":"Ig_Fc_receptor"}]},{"database":"InterPro","id":"IPR040878","properties":[{"key":"EntryName","value":"IL-40-like_Ig"}]},{"database":"PANTHER","id":"PTHR11481:SF101","properties":[{"key":"EntryName","value":"FC RECEPTOR-LIKE PROTEIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11481","properties":[{"key":"EntryName","value":"IMMUNOGLOBULIN FC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17736","properties":[{"key":"EntryName","value":"Ig_C17orf99"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLLWMVLLLCESMAEAQELFPNPELTEFTNSETMDVILKCTIKVDPKNPTLQLFYTFYKNNHVIQDRSPHSVFSAEAKEENSGLYQCMVDTEDGLIQKKSGYLDIQFWTPVSHPVLTLQHEATNLAVGDKVEFLCEAHQGSLPIFYSFYINGEILGKPLAPSGRAASLLASVKAEWSTKNYSCEAKNNISREISELKKFPLVVSGTAWIKSNMLPIWLPASLLGGMVIAAVVLMYFFKPCKKHARPETPTLKEPDSFLYVSVDNQRYK","length":268,"molWeight":30237,"crc64":"C75B513EA34DB0E7","md5":"AC0166F9FBA7FCAB9F485925199323CE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":1,"Glycosylation":2,"Disulfide bond":1,"Alternative sequence":2,"Sequence conflict":1},"uniParcId":"UPI0001B3CB35"}}