{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0L1D3","uniProtkbId":"DARP_SHESA","entryAudit":{"firstPublicDate":"2008-01-15","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2006-12-12","entryVersion":86,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Shewanella sp. (strain ANA-3)","taxonId":94122,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Alteromonadales","Shewanellaceae","Shewanella"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"Dual-action ribosomal maturation protein DarP"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"Large ribosomal subunit assembly factor DarP"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"darP"},"orderedLocusNames":[{"value":"Shewana3_3632"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"Member of a network of 50S ribosomal subunit biogenesis factors which assembles along the 30S-50S interface, preventing incorrect 23S rRNA structures from forming. Promotes peptidyl transferase center (PTC) maturation"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"Associates with late stage pre-50S ribosomal subunits"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00765"}],"value":"Belongs to the DarP family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Dual-action ribosomal maturation protein DarP","featureId":"PRO_1000046803"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0690","category":"Biological process","name":"Ribosome biogenesis"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0699","category":"Molecular function","name":"rRNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9Q8QQ3CBIRCPN","citationType":"submission","authors":["Copeland A.","Lucas S.","Lapidus A.","Barry K.","Detter J.C.","Glavina del Rio T.","Hammon N.","Israni S.","Dalin E.","Tice H.","Pitluck S.","Chertkov O.","Brettin T.","Bruce D.","Han C.","Tapia R.","Gilna P.","Schmutz J.","Larimer F.","Land M.","Hauser L.","Kyrpides N.","Kim E.","Newman D.","Salticov C.","Konstantinidis K.","Klappenback J.","Tiedje J.","Richardson P."],"title":"Complete sequence of chromosome 1 of Shewanella sp. ANA-3.","publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ANA-3","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP000469","properties":[{"key":"ProteinId","value":"ABK49852.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_011625015.1","properties":[{"key":"NucleotideSequenceId","value":"NC_008577.1"}]},{"database":"AlphaFoldDB","id":"A0L1D3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0L1D3","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"94122.Shewana3_3632","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"94729553","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"shn:Shewana3_3632","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3028","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_106757_2_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5293604at2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043022","properties":[{"key":"GoTerm","value":"F:ribosome binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019843","properties":[{"key":"GoTerm","value":"F:rRNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:1902626","properties":[{"key":"GoTerm","value":"P:assembly of large subunit precursor of preribosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16331","properties":[{"key":"EntryName","value":"YjgA-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.60.30","properties":[{"key":"EntryName","value":"PSPTO4464-like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00765","properties":[{"key":"EntryName","value":"DarP"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006839","properties":[{"key":"EntryName","value":"DarP"}]},{"database":"InterPro","id":"IPR023153","properties":[{"key":"EntryName","value":"DarP_sf"}]},{"database":"NCBIfam","id":"NF003593","properties":[{"key":"EntryName","value":"PRK05255.1-1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38101","properties":[{"key":"EntryName","value":"UPF0307 PROTEIN YJGA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38101:SF1","properties":[{"key":"EntryName","value":"UPF0307 PROTEIN YJGA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04751","properties":[{"key":"EntryName","value":"DarP"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF016183","properties":[{"key":"EntryName","value":"UCP016183"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF158710","properties":[{"key":"EntryName","value":"PSPTO4464-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKIVGDSEHFKQPYDSDEEYVSKTEDKRDCEAAQKVGMELVSLSKTQLDKIELDEHLYDSIQQAHKIKPKTEAYRRHMQYIGKLMRNVDVEPIKAALAIVLNKNNNETAKLQMFEKMRERLLSQGDSEIQTLVEHYPQLDRQKLRTLVRQATKELAKGPESKSSKELFKYLRSEIQD","length":177,"molWeight":20684,"crc64":"8786B523036A8252","md5":"6E8CF72B9765919897C370854FCA85EC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1},"uniParcId":"UPI0000293FB6"}}