{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0JPF9","secondaryAccessions":["E9QIE3","F1R603"],"uniProtkbId":"ISPD_DANRE","entryAudit":{"firstPublicDate":"2008-07-22","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2012-07-11","entryVersion":101,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Danio rerio","commonName":"Zebrafish","synonyms":["Brachydanio rerio"],"taxonId":7955,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Ostariophysi","Cypriniformes","Danionidae","Danioninae","Danio"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"D-ribitol-5-phosphate cytidylyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"2.7.7.40"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"Isoprenoid synthase domain-containing protein"}}]},"genes":[{"geneName":{"value":"crppa"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"ispd"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"value":"zgc:154151"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22522421"}],"value":"Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522421). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-ribitol 5-phosphate + CTP + H(+) = CDP-L-ribitol + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12456"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37563"},{"database":"ChEBI","id":"CHEBI:57608"},{"database":"ChEBI","id":"CHEBI:57695"}],"ecNumber":"2.7.7.40","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-ribose 5-phosphate + CTP + H(+) = CDP-D-ribose + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53872"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37563"},{"database":"ChEBI","id":"CHEBI:78346"},{"database":"ChEBI","id":"CHEBI:137525"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-ribulose 5-phosphate + CTP + H(+) = CDP-D-ribulose + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53612"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37563"},{"database":"ChEBI","id":"CHEBI:58121"},{"database":"ChEBI","id":"CHEBI:137524"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A4D126"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["A0JPF9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["A0JPF9-2"],"sequenceIds":["VSP_044045"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["A0JPF9-3"],"sequenceIds":["VSP_044046"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22522421"}],"value":"Hydrocephalus and incomplete brain folding by 48 hours post fertilization (h.p.f.), as well as significantly reduced eye size reminiscent of microphthalmia in patients suffering of muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies in human"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"D-ribitol-5-phosphate cytidylyltransferase","featureId":"PRO_0000343700"},{"type":"Site","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q46893"}]},{"type":"Site","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q46893"}]},{"type":"Site","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Positions substrate for the nucleophilic attack","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q46893"}]},{"type":"Site","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Positions substrate for the nucleophilic attack","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q46893"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_044045","alternativeSequence":{"originalSequence":"MGTVTIQLSCLRHIRKLCFSCPWEGRRLFKMLLQFHHETQ","alternativeSequences":["MNTAATNAELIETKEKMQQERCSSSD"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_044046","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in Ref. 2; AAI27406","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"in Ref. 2; AAI27406","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in Ref. 2; AAI27406","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"in Ref. 2; AAI27406","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"in Ref. 2; AAI27406","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"23594743","citationType":"journal article","authors":["Howe K.","Clark M.D.","Torroja C.F.","Torrance J.","Berthelot C.","Muffato M.","Collins J.E.","Humphray S.","McLaren K.","Matthews L.","McLaren S.","Sealy I.","Caccamo M.","Churcher C.","Scott C.","Barrett J.C.","Koch R.","Rauch G.J.","White S.","Chow W.","Kilian B.","Quintais L.T.","Guerra-Assuncao J.A.","Zhou Y.","Gu Y.","Yen J.","Vogel J.H.","Eyre T.","Redmond S.","Banerjee R.","Chi J.","Fu B.","Langley E.","Maguire S.F.","Laird G.K.","Lloyd D.","Kenyon E.","Donaldson S.","Sehra H.","Almeida-King J.","Loveland J.","Trevanion S.","Jones M.","Quail M.","Willey D.","Hunt A.","Burton J.","Sims S.","McLay K.","Plumb B.","Davis J.","Clee C.","Oliver K.","Clark R.","Riddle C.","Elliot D.","Threadgold G.","Harden G.","Ware D.","Begum S.","Mortimore B.","Kerry G.","Heath P.","Phillimore B.","Tracey A.","Corby N.","Dunn M.","Johnson C.","Wood J.","Clark S.","Pelan S.","Griffiths G.","Smith M.","Glithero R.","Howden P.","Barker N.","Lloyd C.","Stevens C.","Harley J.","Holt K.","Panagiotidis G.","Lovell J.","Beasley H.","Henderson C.","Gordon D.","Auger K.","Wright D.","Collins J.","Raisen C.","Dyer L.","Leung K.","Robertson L.","Ambridge K.","Leongamornlert D.","McGuire S.","Gilderthorp R.","Griffiths C.","Manthravadi D.","Nichol S.","Barker G.","Whitehead S.","Kay M.","Brown J.","Murnane C.","Gray E.","Humphries M.","Sycamore N.","Barker D.","Saunders D.","Wallis J.","Babbage A.","Hammond S.","Mashreghi-Mohammadi M.","Barr L.","Martin S.","Wray P.","Ellington A.","Matthews N.","Ellwood M.","Woodmansey R.","Clark G.","Cooper J.","Tromans A.","Grafham D.","Skuce C.","Pandian R.","Andrews R.","Harrison E.","Kimberley A.","Garnett J.","Fosker N.","Hall R.","Garner P.","Kelly D.","Bird C.","Palmer S.","Gehring I.","Berger A.","Dooley C.M.","Ersan-Urun Z.","Eser C.","Geiger H.","Geisler M.","Karotki L.","Kirn A.","Konantz J.","Konantz M.","Oberlander M.","Rudolph-Geiger S.","Teucke M.","Lanz C.","Raddatz G.","Osoegawa K.","Zhu B.","Rapp A.","Widaa S.","Langford C.","Yang F.","Schuster S.C.","Carter N.P.","Harrow J.","Ning Z.","Herrero J.","Searle S.M.","Enright A.","Geisler R.","Plasterk R.H.","Lee C.","Westerfield M.","de Jong P.J.","Zon L.I.","Postlethwait J.H.","Nusslein-Volhard C.","Hubbard T.J.","Roest Crollius H.","Rogers J.","Stemple D.L."],"citationCrossReferences":[{"database":"PubMed","id":"23594743"},{"database":"DOI","id":"10.1038/nature12111"}],"title":"The zebrafish reference genome sequence and its relationship to the human genome.","publicationDate":"2013","journal":"Nature","firstPage":"498","lastPage":"503","volume":"496"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Tuebingen","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-6LS8ATIE0L92E","citationType":"submission","authoringGroup":["NIH - Zebrafish Gene Collection (ZGC) project"],"publicationDate":"NOV-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"22522421","citationType":"journal article","authors":["Roscioli T.","Kamsteeg E.J.","Buysse K.","Maystadt I.","van Reeuwijk J.","van den Elzen C.","van Beusekom E.","Riemersma M.","Pfundt R.","Vissers L.E.","Schraders M.","Altunoglu U.","Buckley M.F.","Brunner H.G.","Grisart B.","Zhou H.","Veltman J.A.","Gilissen C.","Mancini G.M.","Delree P.","Willemsen M.A.","Ramadza D.P.","Chitayat D.","Bennett C.","Sheridan E.","Peeters E.A.","Tan-Sindhunata G.M.","de Die-Smulders C.E.","Devriendt K.","Kayserili H.","El-Hashash O.A.","Stemple D.L.","Lefeber D.J.","Lin Y.Y.","van Bokhoven H."],"citationCrossReferences":[{"database":"PubMed","id":"22522421"},{"database":"DOI","id":"10.1038/ng.2253"}],"title":"Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of alpha-dystroglycan.","publicationDate":"2012","journal":"Nat. Genet.","firstPage":"581","lastPage":"585","volume":"44"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX470068","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FP102309","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC127405","properties":[{"key":"ProteinId","value":"AAI27406.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001071270.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001077802.1"}]},{"database":"RefSeq","id":"XP_005157821.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005157764.5"}],"isoformId":"A0JPF9-2"},{"database":"AlphaFoldDB","id":"A0JPF9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0JPF9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A0JPF9","properties":[{"key":"Number of interactors","value":"82"}]},{"database":"STRING","id":"7955.ENSDARP00000025837","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"7955-ENSDARP00000025837","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0JPF9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"798716","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dre:798716","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"ZFIN:ZDB-GENE-061110-16","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"729920","properties":[{"key":"Description","value":"-"}]},{"database":"ZFIN","id":"ZDB-GENE-061110-16","properties":[{"key":"GeneName","value":"crppa"}]},{"database":"eggNOG","id":"ENOG502QUUE","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_033636_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A0JPF9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LKEWNFI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"414267at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-DRE-9939291","properties":[{"key":"PathwayName","value":"Matriglycan biosynthesis on DAG1"}]},{"database":"UniPathway","id":"UPA00378","properties":[{"key":"RectionId","value":"-"}]},{"database":"PRO","id":"PR:A0JPF9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000437","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSDARG00000005034","properties":[{"key":"ExpressionPatterns","value":"Expressed in testis and 26 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070567","properties":[{"key":"GoTerm","value":"F:cytidylyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0047349","properties":[{"key":"GoTerm","value":"F:D-ribitol-5-phosphate cytidylyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048854","properties":[{"key":"GoTerm","value":"P:brain morphogenesis"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22522421"}]},{"database":"GO","id":"GO:0008299","properties":[{"key":"GoTerm","value":"P:isoprenoid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0055001","properties":[{"key":"GoTerm","value":"P:muscle cell development"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22522421"}]},{"database":"GO","id":"GO:0035269","properties":[{"key":"GoTerm","value":"P:protein O-linked glycosylation via mannose"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22522421"}]},{"database":"GO","id":"GO:0010559","properties":[{"key":"GoTerm","value":"P:regulation of glycoprotein biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22522421"}]},{"database":"CDD","id":"cd02516","properties":[{"key":"EntryName","value":"CDP-ME_synthetase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.550.10:FF:000080","properties":[{"key":"EntryName","value":"D-ribitol-5-phosphate cytidylyltransferase isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR034683","properties":[{"key":"EntryName","value":"IspD/TarI"}]},{"database":"InterPro","id":"IPR040635","properties":[{"key":"EntryName","value":"ISPD_C"}]},{"database":"InterPro","id":"IPR018294","properties":[{"key":"EntryName","value":"ISPD_synthase_CS"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"PANTHER","id":"PTHR43015","properties":[{"key":"EntryName","value":"D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43015:SF1","properties":[{"key":"EntryName","value":"D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01128","properties":[{"key":"EntryName","value":"IspD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18706","properties":[{"key":"EntryName","value":"ISPD_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01295","properties":[{"key":"EntryName","value":"ISPD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGTVTIQLSCLRHIRKLCFSCPWEGRRLFKMLLQFHHETQRPLDPGCLLPQDAERSADQPGRAVVDFPVAAVLPAGGSGERMGLTTPKQFCSIFNRPLISYTIQAFERLPWIVMVVVVVAKDNHDLMLNIVRKFNHTKVKVVHGGTTRHRSIYNGLQAFSDSTDSSTPKPKVVIIHDAVRPFVEEDLLLKITLAAKEQGASGAIRPLVSTVIATTSESYLDHSLERAKYRASEMPQGFLYDIIFQAYQRCSEFDLEFGTECLHLALQYCGTNARLIEGPPTLWKVTYKRDLAAAEAIIKETLSVSACIIAEAEEEAVELAKTLQKNLNMMETDVIPCGKESNVQYLSKTRNFIHISASASSSLWVLEMVKCFEDIDHARLYPVVIVWVQLSMTKQSADSQETDEFMALASEVKQRNVLLYGIKIDHSKELEQWQRSLERLGQITLVLIRDRNMALTGQMLHV","length":462,"molWeight":52064,"crc64":"1B09E78803C379CE","md5":"894B88CCC19034B32E021C53D1CE8783"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Site":4,"Alternative sequence":2,"Sequence conflict":5},"uniParcId":"UPI0002656643"}}