{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0JP70","uniProtkbId":"WDR90_XENTR","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-12-12","entryVersion":87,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Xenopus tropicalis","commonName":"Western clawed frog","synonyms":["Silurana tropicalis"],"taxonId":8364,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Pipoidea","Pipidae","Xenopodinae","Xenopus","Silurana"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"WD repeat-containing protein 90"}}},"genes":[{"geneName":{"value":"wdr90"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96KV7"}],"value":"Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability. Required for efficient primary cilium formation"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96KV7"}],"value":"Localizes to the microtubule triplets in the central core region of centrioles and localizes to centriolar satellite in a PCM1-dependent manner"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96KV7"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole","id":"SL-0046"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96KV7"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite","id":"SL-0485"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the WD repeat WDR90/POC16 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1848,"modifier":"EXACT"}},"description":"WD repeat-containing protein 90","featureId":"PRO_0000341414"},{"type":"Repeat","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"WD 1"},{"type":"Repeat","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"WD 2"},{"type":"Repeat","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"WD 3"},{"type":"Repeat","location":{"start":{"value":644,"modifier":"EXACT"},"end":{"value":683,"modifier":"EXACT"}},"description":"WD 4"},{"type":"Repeat","location":{"start":{"value":685,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"WD 5"},{"type":"Repeat","location":{"start":{"value":727,"modifier":"EXACT"},"end":{"value":766,"modifier":"EXACT"}},"description":"WD 6"},{"type":"Repeat","location":{"start":{"value":769,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"WD 7"},{"type":"Repeat","location":{"start":{"value":811,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"WD 8"},{"type":"Repeat","location":{"start":{"value":955,"modifier":"EXACT"},"end":{"value":993,"modifier":"EXACT"}},"description":"WD 9"},{"type":"Repeat","location":{"start":{"value":998,"modifier":"EXACT"},"end":{"value":1035,"modifier":"EXACT"}},"description":"WD 10"},{"type":"Repeat","location":{"start":{"value":1252,"modifier":"EXACT"},"end":{"value":1297,"modifier":"EXACT"}},"description":"WD 11"},{"type":"Repeat","location":{"start":{"value":1300,"modifier":"EXACT"},"end":{"value":1341,"modifier":"EXACT"}},"description":"WD 12"},{"type":"Repeat","location":{"start":{"value":1343,"modifier":"EXACT"},"end":{"value":1382,"modifier":"EXACT"}},"description":"WD 13"},{"type":"Repeat","location":{"start":{"value":1395,"modifier":"EXACT"},"end":{"value":1433,"modifier":"EXACT"}},"description":"WD 14"},{"type":"Repeat","location":{"start":{"value":1435,"modifier":"EXACT"},"end":{"value":1473,"modifier":"EXACT"}},"description":"WD 15"},{"type":"Repeat","location":{"start":{"value":1532,"modifier":"EXACT"},"end":{"value":1571,"modifier":"EXACT"}},"description":"WD 16"},{"type":"Repeat","location":{"start":{"value":1574,"modifier":"EXACT"},"end":{"value":1621,"modifier":"EXACT"}},"description":"WD 17"},{"type":"Repeat","location":{"start":{"value":1624,"modifier":"EXACT"},"end":{"value":1663,"modifier":"EXACT"}},"description":"WD 18"},{"type":"Repeat","location":{"start":{"value":1670,"modifier":"EXACT"},"end":{"value":1714,"modifier":"EXACT"}},"description":"WD 19"},{"type":"Repeat","location":{"start":{"value":1774,"modifier":"EXACT"},"end":{"value":1813,"modifier":"EXACT"}},"description":"WD 20"},{"type":"Repeat","location":{"start":{"value":1815,"modifier":"EXACT"},"end":{"value":1848,"modifier":"EXACT"}},"description":"WD 21"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Binds with microtubules","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96KV7"}]},{"type":"Region","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1053,"modifier":"EXACT"},"end":{"value":1133,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1151,"modifier":"EXACT"},"end":{"value":1178,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1102,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1114,"modifier":"EXACT"},"end":{"value":1129,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1164,"modifier":"EXACT"},"end":{"value":1178,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2IMPSC70KSOVK","citationType":"submission","authoringGroup":["NIH - Xenopus Gene Collection (XGC) project"],"publicationDate":"NOV-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC127273","properties":[{"key":"ProteinId","value":"AAI27274.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001090645.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001097176.1"}]},{"database":"AlphaFoldDB","id":"A0JP70","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A0JP70","properties":[{"key":"Number of interactors","value":"471"}]},{"database":"STRING","id":"8364.ENSXETP00000002969","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"8364-ENSXETP00000002969","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"100036617","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSXETT00000007829","properties":[{"key":"ProteinId","value":"ENSXETP00000007829"},{"key":"GeneId","value":"ENSXETG00000003627"}]},{"database":"GeneID","id":"100036617","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"xtr:100036617","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"Xenbase:XB-GENE-5825492","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"197335","properties":[{"key":"Description","value":"-"}]},{"database":"Xenbase","id":"XB-GENE-5825492","properties":[{"key":"GeneName","value":"wdr90"}]},{"database":"eggNOG","id":"KOG0266","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG0267","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG3213","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160173","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A0JP70","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DHYVHIR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6252103at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000008143","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSXETG00000003627","properties":[{"key":"ExpressionPatterns","value":"Expressed in 2-cell stage embryo and 8 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0JP70","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0034451","properties":[{"key":"GoTerm","value":"C:centriolar satellite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005814","properties":[{"key":"GoTerm","value":"C:centriole"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061511","properties":[{"key":"GoTerm","value":"P:centriole elongation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"FunFam","id":"2.130.10.10:FF:000522","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000590","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:001223","properties":[{"key":"EntryName","value":"WD repeat-containing protein 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:001872","properties":[{"key":"EntryName","value":"WD repeat-containing protein 90"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"6"}]},{"database":"InterPro","id":"IPR055439","properties":[{"key":"EntryName","value":"Beta-prop_EML_1st"}]},{"database":"InterPro","id":"IPR055440","properties":[{"key":"EntryName","value":"Beta-prop_WDR90_4th"}]},{"database":"InterPro","id":"IPR055441","properties":[{"key":"EntryName","value":"Beta-prop_WDR90_POC16_2nd"}]},{"database":"InterPro","id":"IPR007714","properties":[{"key":"EntryName","value":"CFA20_dom"}]},{"database":"InterPro","id":"IPR011047","properties":[{"key":"EntryName","value":"Quinoprotein_ADH-like_sf"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050630","properties":[{"key":"EntryName","value":"WD_repeat_EMAP"}]},{"database":"PANTHER","id":"PTHR13720:SF24","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN 90"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13720","properties":[{"key":"EntryName","value":"WD-40 REPEAT PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23409","properties":[{"key":"EntryName","value":"Beta-prop_EML"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23393","properties":[{"key":"EntryName","value":"Beta-prop_WDR90_POC16_2nd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05018","properties":[{"key":"EntryName","value":"CFA20_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23342","properties":[{"key":"EntryName","value":"WDR90_beta-prop_4th"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"21"}]},{"database":"SUPFAM","id":"SSF50998","properties":[{"key":"EntryName","value":"Quinoprotein alcohol dehydrogenase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MAGVWQHPFVNVFKHLRLEEWKKSSKEGDVTSVMDKTLKCTVYRIRGSIPAGNYIQLPKTSSQSLGLTGRYLYILFKPLPGKHFVVHIDVSAEDGQTVRISFSNLFKEFKSTATWLQFPFVCGAIKGSVYDSTAQGARQGMVGPAPSGSRWTCLLLDVQYILSLYLSRRYSHLRSAKLCSNLLVRNLMTSDLLFNPEVNFMEARHAKTLPDGISPMPREMSFPVPKGEKWHDLYDFIMFPSDSSKLPYDSIQKGQSMVTAPGAPMSRSPARERPRSVTISKPVQDRVSLIQQITTPRPMPHRSLLRVESVPERPVSVSARAEEARDLEDRSRGVEQDGGVHVYAHKTNKLSIHRHKSDSEQVICTKVDRPETLSVPPECKKLLPDPIFNLRRIIGFGGCTECFALWTHTGCSVVYPCHAIIVVLEVKTGEQRFLLGHTDKVSALAFNGSCTLLASAQTGSLSMVRLWHFQKGSCLAMFKTHVHSVSYLSFSHSGTVLCGVGKDGHGKTMVVVWNTSQASRSGEVAVLAKAHTDIDIQTMKIAFFDDTRMVSCGKDNVRLWRVRGGTLRSCPVNLGEYHMLEFSDLAFEAGHRPEKEAEDRTLYVSSRSGHILEIDYKNVVLRNVRRVQPGQQQHSERRDKQTFSSGPGIAINSLSVSATFCATGTEDGYLRLWPLDFSGVFLEAEHEGPVSCVAISPEGLRVLSCTSSGELGVLDVPSRGYNTLMRSHTDTLLSFSCHPTHPQLVTVSSDNTIRIWDTGTLQQLYDFTAEEETPCAVTFHPVRQAFACGFSSGTIRFFDITATALQAEHKQHRGAITGLLFSPDGSLMYSCCSLGSVALYSIGHKEQHVLRVLGNVVCKDSERGPMALSLSSDGRLLAFVGPTEYTVTVMDARSLDELLRVDVSILDLDSTTLDCALGLAFSPLKPHHLLVSTSGNKILWLDPKTGRLTREVTQVHKQCCSSLAVSMDTRYMLTAGDRLLKVWDQRQPGTVRPQVFIGHSEAVQQVDFSPDQQSVISAGDAVFIWDFLAAPDPEFTKTDCVPALPFALHSSAALDPSSEHRRDSTFISSGMPRGTAPRPCISSPPRLDISPVQGMDHPDLFSESDDGQEEEGNRDEQERTLVPDTRDNLVESDEQSSVVIIECQPNRAKLLTGSKSNSSSLREGMVKSTHEPPRPDSYTHFHTRFKASCLAKGMCHPPEGQEMLTLRALIGYNGNGRANMAWNPDTGFFSYTCGCVIVVEDLHSGSQRHWLGHPEEISTLALTNDALVLASASGSGDGSSLCQIRIWDTQDGSCMKILTHHRTEVQAMSYSRDDRLFVSIGDYRDGNLALWSTKGYELLATSRLFQPVHAVTFNPAHFDDFASAGPGAVSFWRIETQGTDTQIKVYRVAVPEEVGTAAELTSITYNSTSLLYSGCSTGQVCVWDCQTHRCFLTWEADQGEIGILLCRGNRLLTGSNTRRIRLWCVAAVQELREKGSGASSTSVLMEHEMTLDGAIVSATFDDALEMGIVGTTAGTLWYINWVENTSIRLISGHRNKVMDLAVAHGESHCATCGEDGSLRIWSLQSCELLLQFQVLNQSCLCLAWSPQPKSGPSTEDQRIAAGYSDGTIRIFSVSKTEMEMKIHPHPCAVTSIAYSTSGDVLLTGGKDGQMAITSPRTGMTIRVLSDHKGSPITTIECTGRKLTGLPTDGELWLAASTDRRVSIWASDWSKDKCELLDWLSFPAPTSQKDLDVSVPTLAAFCPWQPGTVVYSGFGVEKEILFYSLIQKQVLLRIPLSHFATSLTLSPAASLIAVGSNERLLRLIDTSAGTKQDFAAYDDGVHLCRVSPSGNLLLTASYNQVLVWDIQNS","length":1848,"molWeight":203426,"crc64":"FCC2529BE88F62FC","md5":"372E9D7A2BF81C8233400E97816ED96D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Repeat":21,"Region":5,"Compositional bias":4},"uniParcId":"UPI0000E674E8"}}