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May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localizes to a polar structure adjacent to the basal body"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23900544"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23900544"}],"value":"Multiciliated cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23900544"}],"value":"Up-regulated by foxj1 during motile cilia formation"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23900544"}],"value":"Cilia in multiciliate cells are motile but fail to produce flow. Multiciliated cells are present in the normal number, cilia of normal length and of normal density. They are however misoriented"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BBOF1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"Basal body-orientation factor 1","featureId":"PRO_0000281127"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":465,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2IMPUPI2GJMN1","citationType":"submission","authoringGroup":["NIH - Xenopus Gene Collection (XGC) project"],"publicationDate":"OCT-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"23900544","citationType":"journal article","authors":["Chien Y.H.","Werner M.E.","Stubbs J.","Joens M.S.","Li J.","Chien S.","Fitzpatrick J.A.","Mitchell B.J.","Kintner C."],"citationCrossReferences":[{"database":"PubMed","id":"23900544"},{"database":"DOI","id":"10.1242/dev.096727"}],"title":"Bbof1 is required to maintain cilia orientation.","publicationDate":"2013","journal":"Development","firstPage":"3468","lastPage":"3477","volume":"140"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","INDUCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC126050","properties":[{"key":"ProteinId","value":"AAI26051.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001090552.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001097083.1"}]},{"database":"AlphaFoldDB","id":"A0JMY4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0JMY4","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"100036788","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"100036788","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"xla:100036788","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"Xenbase:XB-GENE-5831975","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"100036788","properties":[{"key":"Description","value":"-"}]},{"database":"Xenbase","id":"XB-GENE-5831975","properties":[{"key":"GeneName","value":"bbof1.L"}]},{"database":"OrthoDB","id":"441129at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000186698","properties":[{"key":"Component","value":"Chromosome 8L"}]},{"database":"Bgee","id":"100036788","properties":[{"key":"ExpressionPatterns","value":"Expressed in internal ear and 10 other cell types or tissues"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23900544"}]},{"database":"GO","id":"GO:0044458","properties":[{"key":"GoTerm","value":"P:motile cilium assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23900544"}]},{"database":"InterPro","id":"IPR032777","properties":[{"key":"EntryName","value":"DUF4515"}]},{"database":"PANTHER","id":"PTHR14845:SF5","properties":[{"key":"EntryName","value":"BASAL BODY-ORIENTATION FACTOR 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14845","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING 166"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14988","properties":[{"key":"EntryName","value":"DUF4515"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPKLKVKAGKGKKGKRKKAGKNEHRLDKESEVERARSNAALWEARLKVTEFSRVEYRDAARSLAQNNEDLTKQQYKLEKDMVEVIGFLKKQDLEKDELIEKLQQNLIAQKKSAQDEREKLVELYSKQIAHLEENYSQKTNEMQIIQSEFKLMREFRRQKVELEKELDEVKESLWRANQDHKETLARMERRFFEEKQRLEKEAEKKIMMLAEKAHSEAIIQLDEARKSVFKENVRLKEAFSYHLKEMKDIKKSKKMQEDAKLHLLQEKETNDLLVQEKVSQVSQKKVQIQELQQNVKALECALERMTMEMEKDAQGKEHQALLQEQAGNVELQKLQKVLHMKEREMNRIKKLARNILEERTEVESFFLEALWQVKQEIATSRNYYRQVAQSAYTSKMIQASLGKDQYPKIRTFHNKEHSTNDVSHDLSEAEKWTHIQAGKVDIGDLTWEQKEKVLRLLFAKMNGFQSRKSPGLKPSPPADVSSIKEKEINTSNLEEKPEESSSTFITQSIPELPAPSLVLPHIQTGRCQVTG","length":531,"molWeight":62167,"crc64":"1C419D11BDA0118D","md5":"BA0836246757175533BB150A739FB254"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Coiled coil":2,"Compositional bias":3},"uniParcId":"UPI0000E673FC"}}