{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0A7U3TBV3","uniProtkbId":"DGTPH_BPS2L","entryAudit":{"firstPublicDate":"2021-09-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":12,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cyanophage S-2L","commonName":"Cyanobacteria phage S-2L","taxonId":260586,"lineage":["Viruses","Duplodnaviria","Heunggongvirae","Uroviricota","Caudoviricetes"]},"organismHosts":[{"scientificName":"Synechococcus","taxonId":1129}],"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"dATP/dGTP diphosphohydrolase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}],"value":"3.6.1.9"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}],"value":"dATP/dGTP pyrophosphohydrolase"}}]},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"QQG31318.1"}],"value":"S2L_23"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}],"value":"Catalyzes the hydrolysis of dGTP into dGMP, which is needed among other for the first step of biosynthesis of dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dGTP + H2O = dGMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28362"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:57673"},{"database":"ChEBI","id":"CHEBI:61429"}],"ecNumber":"3.6.1.9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dATP + H2O = dAMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28334"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58245"},{"database":"ChEBI","id":"CHEBI:61404"}],"ecNumber":"3.6.1.9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Co(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:48828"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2H5BHG5"}],"value":"Purine metabolism"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Caudovirales dATP/dGTP diphosphohydrolase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"dATP/dGTP diphosphohydrolase","featureId":"PRO_0000453686"},{"type":"Helix","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ODY"}]},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ODY"}]},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ODY"}]},{"type":"Helix","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ODY"}]},{"type":"Beta strand","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ODY"}]},{"type":"Beta strand","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ODY"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0170","category":"Ligand","name":"Cobalt"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-24GAM8HGF69DF","citationType":"submission","authors":["Kaminski P.A."],"publicationDate":"DEC-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MW334946","properties":[{"key":"ProteinId","value":"QQG31318.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"7ODY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A/B/C/D=1-105"}]},{"database":"PDBsum","id":"7ODY","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"A0A7U3TBV3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7U3TBV3","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ag:QQG31318","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008828","properties":[{"key":"GoTerm","value":"F:dATP diphosphatase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036217","properties":[{"key":"GoTerm","value":"F:dGTP diphosphatase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0000166","properties":[{"key":"GoTerm","value":"F:nucleotide binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"Gene3D","id":"1.10.287.1080","properties":[{"key":"EntryName","value":"MazG-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007538","properties":[{"key":"EntryName","value":"dATP/dGTP_dipphydrolase_MazZ"}]},{"database":"Pfam","id":"PF04447","properties":[{"key":"EntryName","value":"dATP-dGTP_PPHyd"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF101386","properties":[{"key":"EntryName","value":"all-alpha NTP pyrophosphatases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPATVAELQAEIAAWIHPLNPDRRPGGTIAKLLEEIGELIASDRAHDPLEVADVLILALDLATLLGVDVTEAIRAKLAINRARSWARADNGAMRHIPGSDTPSFP","length":105,"molWeight":11250,"crc64":"A6DFCB5D6DE540B8","md5":"06D6EACBD86CEE9A2C52A2B1CBE3C209"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Helix":4,"Beta strand":2},"uniParcId":"UPI0019389738"}}