{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0A7P0TBJ1","uniProtkbId":"HAPR2_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2021-06-02","entryVersion":21,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"36631436"}],"value":"HUWE1-associated protein modifying stress responses 2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:55138"}],"value":"HAPSTR2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36631436"}],"value":"Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding (PubMed:36631436). Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1 (PubMed:36631436)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36631436"}],"value":"Homooligomer (PubMed:36631436). Heterooligomer with HAPSTR1; the interaction is direct and stabilizes HAPSTR1 independently of HUWE1 (PubMed:36631436). Interacts with HUWE1 (PubMed:36631436)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36631436"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36631436"}],"value":"Expressed in a tissue-restricted manner compared to HAPSTR1"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the HAPSTR1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"HUWE1-associated protein modifying stress responses 2","featureId":"PRO_0000457925"},{"type":"Region","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36631436"}]},{"type":"Region","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Mutagenesis","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Loss of homodimerization. Loss of heterodimerization with HAPSTR1. No effect on interaction with HUWE1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36631436"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15772651","citationType":"journal article","authors":["Ross M.T.","Grafham D.V.","Coffey A.J.","Scherer S.","McLay K.","Muzny D.","Platzer M.","Howell G.R.","Burrows C.","Bird C.P.","Frankish A.","Lovell F.L.","Howe K.L.","Ashurst J.L.","Fulton R.S.","Sudbrak R.","Wen G.","Jones M.C.","Hurles M.E.","Andrews T.D.","Scott C.E.","Searle S.","Ramser J.","Whittaker A.","Deadman R.","Carter N.P.","Hunt S.E.","Chen R.","Cree A.","Gunaratne P.","Havlak P.","Hodgson A.","Metzker M.L.","Richards S.","Scott G.","Steffen D.","Sodergren E.","Wheeler D.A.","Worley K.C.","Ainscough R.","Ambrose K.D.","Ansari-Lari M.A.","Aradhya S.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Ballabio A.","Banerjee R.","Barker G.E.","Barlow K.F.","Barrett I.P.","Bates K.N.","Beare D.M.","Beasley H.","Beasley O.","Beck A.","Bethel G.","Blechschmidt K.","Brady N.","Bray-Allen S.","Bridgeman A.M.","Brown A.J.","Brown M.J.","Bonnin D.","Bruford E.A.","Buhay C.","Burch P.","Burford D.","Burgess J.","Burrill W.","Burton J.","Bye J.M.","Carder C.","Carrel L.","Chako J.","Chapman J.C.","Chavez D.","Chen E.","Chen G.","Chen Y.","Chen Z.","Chinault C.","Ciccodicola A.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Clerc-Blankenburg K.","Clifford K.","Cobley V.","Cole C.G.","Conquer J.S.","Corby N.","Connor R.E.","David R.","Davies J.","Davis C.","Davis J.","Delgado O.","Deshazo D.","Dhami P.","Ding Y.","Dinh H.","Dodsworth S.","Draper H.","Dugan-Rocha S.","Dunham A.","Dunn M.","Durbin K.J.","Dutta I.","Eades T.","Ellwood M.","Emery-Cohen A.","Errington H.","Evans K.L.","Faulkner L.","Francis F.","Frankland J.","Fraser A.E.","Galgoczy P.","Gilbert J.","Gill R.","Gloeckner G.","Gregory S.G.","Gribble S.","Griffiths C.","Grocock R.","Gu Y.","Gwilliam R.","Hamilton C.","Hart E.A.","Hawes A.","Heath P.D.","Heitmann K.","Hennig S.","Hernandez J.","Hinzmann B.","Ho S.","Hoffs M.","Howden P.J.","Huckle E.J.","Hume J.","Hunt P.J.","Hunt A.R.","Isherwood J.","Jacob L.","Johnson D.","Jones S.","de Jong P.J.","Joseph S.S.","Keenan S.","Kelly S.","Kershaw J.K.","Khan Z.","Kioschis P.","Klages S.","Knights A.J.","Kosiura A.","Kovar-Smith C.","Laird G.K.","Langford C.","Lawlor S.","Leversha M.","Lewis L.","Liu W.","Lloyd C.","Lloyd D.M.","Loulseged H.","Loveland J.E.","Lovell J.D.","Lozado R.","Lu J.","Lyne R.","Ma J.","Maheshwari M.","Matthews L.H.","McDowall J.","McLaren S.","McMurray A.","Meidl P.","Meitinger T.","Milne S.","Miner G.","Mistry S.L.","Morgan M.","Morris S.","Mueller I.","Mullikin J.C.","Nguyen N.","Nordsiek G.","Nyakatura G.","O'dell C.N.","Okwuonu G.","Palmer S.","Pandian R.","Parker D.","Parrish J.","Pasternak S.","Patel D.","Pearce A.V.","Pearson D.M.","Pelan S.E.","Perez L.","Porter K.M.","Ramsey Y.","Reichwald K.","Rhodes S.","Ridler K.A.","Schlessinger D.","Schueler M.G.","Sehra H.K.","Shaw-Smith C.","Shen H.","Sheridan E.M.","Shownkeen R.","Skuce C.D.","Smith M.L.","Sotheran E.C.","Steingruber H.E.","Steward C.A.","Storey R.","Swann R.M.","Swarbreck D.","Tabor P.E.","Taudien S.","Taylor T.","Teague B.","Thomas K.","Thorpe A.","Timms K.","Tracey A.","Trevanion S.","Tromans A.C.","d'Urso M.","Verduzco D.","Villasana D.","Waldron L.","Wall M.","Wang Q.","Warren J.","Warry G.L.","Wei X.","West A.","Whitehead S.L.","Whiteley M.N.","Wilkinson J.E.","Willey D.L.","Williams G.","Williams L.","Williamson A.","Williamson H.","Wilming L.","Woodmansey R.L.","Wray P.W.","Yen J.","Zhang J.","Zhou J.","Zoghbi H.","Zorilla S.","Buck D.","Reinhardt R.","Poustka A.","Rosenthal A.","Lehrach H.","Meindl A.","Minx P.J.","Hillier L.W.","Willard H.F.","Wilson R.K.","Waterston R.H.","Rice C.M.","Vaudin M.","Coulson A.","Nelson D.L.","Weinstock G.","Sulston J.E.","Durbin R.M.","Hubbard T.","Gibbs R.A.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"15772651"},{"database":"DOI","id":"10.1038/nature03440"}],"title":"The DNA sequence of the human X chromosome.","publicationDate":"2005","journal":"Nature","firstPage":"325","lastPage":"337","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"36631436","citationType":"journal article","authors":["Amici D.R.","Cingoz H.","Alasady M.J.","Alhayek S.","Phoumyvong C.M.","Sahni N.","Yi S.S.","Mendillo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"36631436"},{"database":"DOI","id":"10.1038/s41467-022-35697-1"}],"title":"The HAPSTR2 retrogene buffers stress signaling and resilience in mammals.","publicationDate":"2023","journal":"Nat. Commun.","firstPage":"152","lastPage":"152","volume":"14"},"referencePositions":["FUNCTION","SUBUNIT","INTERACTION WITH HAPSTR1 AND HUWE1","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","REGION","MUTAGENESIS OF GLY-116"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL589987","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS94678.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001258489.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001271560.3"}]},{"database":"AlphaFoldDB","id":"A0A7P0TBJ1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"A0A7P0TBJ1","properties":[{"key":"Number of interactors","value":"381"}]},{"database":"PeptideAtlas","id":"A0A7P0TBJ1","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000453380.3","properties":[{"key":"ProteinId","value":"ENSP00000506518.1"},{"key":"GeneId","value":"ENSG00000230707.3"}]},{"database":"GeneID","id":"389895","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:389895","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000453380.3","properties":[{"key":"ProteinId","value":"ENSP00000506518.1"},{"key":"RefSeqNucleotideId","value":"NM_001271560.3"},{"key":"RefSeqProteinId","value":"NP_001258489.1"}]},{"database":"AGR","id":"HGNC:55138","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"389895","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HAPSTR2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:55138","properties":[{"key":"GeneName","value":"HAPSTR2"}]},{"database":"MIM","id":"301145","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000230707","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002886","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A0A7P0TBJ1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5823474at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A0A7P0TBJ1","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"Agora","id":"ENSG00000230707","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"PRO","id":"PR:A0A7P0TBJ1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"Bgee","id":"ENSG00000230707","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 77 other cell types or tissues"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36631436"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"36631436"}]},{"database":"GO","id":"GO:0050821","properties":[{"key":"GoTerm","value":"P:protein stabilization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"36631436"}]},{"database":"InterPro","id":"IPR040308","properties":[{"key":"EntryName","value":"HAPR1"}]},{"database":"InterPro","id":"IPR029196","properties":[{"key":"EntryName","value":"HAPSTR1-like"}]},{"database":"PANTHER","id":"PTHR31624:SF2","properties":[{"key":"EntryName","value":"HUWE1-ASSOCIATED PROTEIN MODIFYING STRESS RESPONSES 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31624","properties":[{"key":"EntryName","value":"UPF0472 PROTEIN C16ORF72"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15251","properties":[{"key":"EntryName","value":"TAPR1-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAAELAGLKSEKQKLWHLFQISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESGDAHQRSFDLGVQVGHQRRIKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRTPPKPPTGVTSQAVATESSSSVDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVASSGRRKTSFLEDDLNPFDSEELALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV","length":273,"molWeight":30054,"crc64":"0581F6C93A961839","md5":"F042D758371925CEE8229FA331A86080"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":4,"Compositional bias":4,"Mutagenesis":1},"uniParcId":"UPI000023775D"}}