{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0A0U1RR11","secondaryAccessions":["Q3ZM64"],"uniProtkbId":"CENL1_HUMAN","entryAudit":{"firstPublicDate":"2018-07-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-02-17","entryVersion":52,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Centromere protein V-like protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:31851"}],"value":"Centromere protein V pseudogene 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:31851"}],"value":"CENPVL1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:31851"}],"value":"CENPVP1"}]}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"value":"Binds 2 Zn(2+) ions per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Gfa family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Centromere protein V-like protein 1","featureId":"PRO_0000444697"},{"type":"Domain","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"CENP-V/GFA","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01239"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}}],"keywords":[{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"15772651","citationType":"journal article","authors":["Ross M.T.","Grafham D.V.","Coffey A.J.","Scherer S.","McLay K.","Muzny D.","Platzer M.","Howell G.R.","Burrows C.","Bird C.P.","Frankish A.","Lovell F.L.","Howe K.L.","Ashurst J.L.","Fulton R.S.","Sudbrak R.","Wen G.","Jones M.C.","Hurles M.E.","Andrews T.D.","Scott C.E.","Searle S.","Ramser J.","Whittaker A.","Deadman R.","Carter N.P.","Hunt S.E.","Chen R.","Cree A.","Gunaratne P.","Havlak P.","Hodgson A.","Metzker M.L.","Richards S.","Scott G.","Steffen D.","Sodergren E.","Wheeler D.A.","Worley K.C.","Ainscough R.","Ambrose K.D.","Ansari-Lari M.A.","Aradhya S.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Ballabio A.","Banerjee R.","Barker G.E.","Barlow K.F.","Barrett I.P.","Bates K.N.","Beare D.M.","Beasley H.","Beasley O.","Beck A.","Bethel G.","Blechschmidt K.","Brady N.","Bray-Allen S.","Bridgeman A.M.","Brown A.J.","Brown M.J.","Bonnin D.","Bruford E.A.","Buhay C.","Burch P.","Burford D.","Burgess J.","Burrill W.","Burton J.","Bye J.M.","Carder C.","Carrel L.","Chako J.","Chapman J.C.","Chavez D.","Chen E.","Chen G.","Chen Y.","Chen Z.","Chinault C.","Ciccodicola A.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Clerc-Blankenburg K.","Clifford K.","Cobley V.","Cole C.G.","Conquer J.S.","Corby N.","Connor R.E.","David R.","Davies J.","Davis C.","Davis J.","Delgado O.","Deshazo D.","Dhami P.","Ding Y.","Dinh H.","Dodsworth S.","Draper H.","Dugan-Rocha S.","Dunham A.","Dunn M.","Durbin K.J.","Dutta I.","Eades T.","Ellwood M.","Emery-Cohen A.","Errington H.","Evans K.L.","Faulkner L.","Francis F.","Frankland J.","Fraser A.E.","Galgoczy P.","Gilbert J.","Gill R.","Gloeckner G.","Gregory S.G.","Gribble S.","Griffiths C.","Grocock R.","Gu Y.","Gwilliam R.","Hamilton C.","Hart E.A.","Hawes A.","Heath P.D.","Heitmann K.","Hennig S.","Hernandez J.","Hinzmann B.","Ho S.","Hoffs M.","Howden P.J.","Huckle E.J.","Hume J.","Hunt P.J.","Hunt A.R.","Isherwood J.","Jacob L.","Johnson D.","Jones S.","de Jong P.J.","Joseph S.S.","Keenan S.","Kelly S.","Kershaw J.K.","Khan Z.","Kioschis P.","Klages S.","Knights A.J.","Kosiura A.","Kovar-Smith C.","Laird G.K.","Langford C.","Lawlor S.","Leversha M.","Lewis L.","Liu W.","Lloyd C.","Lloyd D.M.","Loulseged H.","Loveland J.E.","Lovell J.D.","Lozado R.","Lu J.","Lyne R.","Ma J.","Maheshwari M.","Matthews L.H.","McDowall J.","McLaren S.","McMurray A.","Meidl P.","Meitinger T.","Milne S.","Miner G.","Mistry S.L.","Morgan M.","Morris S.","Mueller I.","Mullikin J.C.","Nguyen N.","Nordsiek G.","Nyakatura G.","O'dell C.N.","Okwuonu G.","Palmer S.","Pandian R.","Parker D.","Parrish J.","Pasternak S.","Patel D.","Pearce A.V.","Pearson D.M.","Pelan S.E.","Perez L.","Porter K.M.","Ramsey Y.","Reichwald K.","Rhodes S.","Ridler K.A.","Schlessinger D.","Schueler M.G.","Sehra H.K.","Shaw-Smith C.","Shen H.","Sheridan E.M.","Shownkeen R.","Skuce C.D.","Smith M.L.","Sotheran E.C.","Steingruber H.E.","Steward C.A.","Storey R.","Swann R.M.","Swarbreck D.","Tabor P.E.","Taudien S.","Taylor T.","Teague B.","Thomas K.","Thorpe A.","Timms K.","Tracey A.","Trevanion S.","Tromans A.C.","d'Urso M.","Verduzco D.","Villasana D.","Waldron L.","Wall M.","Wang Q.","Warren J.","Warry G.L.","Wei X.","West A.","Whitehead S.L.","Whiteley M.N.","Wilkinson J.E.","Willey D.L.","Williams G.","Williams L.","Williamson A.","Williamson H.","Wilming L.","Woodmansey R.L.","Wray P.W.","Yen J.","Zhang J.","Zhou J.","Zoghbi H.","Zorilla S.","Buck D.","Reinhardt R.","Poustka A.","Rosenthal A.","Lehrach H.","Meindl A.","Minx P.J.","Hillier L.W.","Willard H.F.","Wilson R.K.","Waterston R.H.","Rice C.M.","Vaudin M.","Coulson A.","Nelson D.L.","Weinstock G.","Sulston J.E.","Durbin R.M.","Hubbard T.","Gibbs R.A.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"15772651"},{"database":"DOI","id":"10.1038/nature03440"}],"title":"The DNA sequence of the human X chromosome.","publicationDate":"2005","journal":"Nature","firstPage":"325","lastPage":"337","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-A51Q6GV8RF78N","citationType":"submission","authors":["Saionz J.R.","Skaletsky H.","Rozen S.","Page D.C."],"title":"Palindromes on the human X chromosome.","publicationDate":"AUG-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 107-272"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC234030","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY730278","properties":[{"key":"ProteinId","value":"AAW56972.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS87745.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001342206.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001355277.1"}]},{"database":"AlphaFoldDB","id":"A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000489273","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"A0A0U1RR11","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"BioMuta","id":"CENPVL1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000489273","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"78259","properties":[{"key":"antibodies","value":"1 antibodies from 1 providers"}]},{"database":"Ensembl","id":"ENST00000602548.2","properties":[{"key":"ProteinId","value":"ENSP00000489273.1"},{"key":"GeneId","value":"ENSG00000223591.5"}]},{"database":"Ensembl","id":"ENST00000634648.1","properties":[{"key":"ProteinId","value":"ENSP00000489328.1"},{"key":"GeneId","value":"ENSG00000283093.1"}]},{"database":"GeneID","id":"389857","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:389857","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000602548.2","properties":[{"key":"ProteinId","value":"ENSP00000489273.1"},{"key":"RefSeqNucleotideId","value":"NM_001355277.1"},{"key":"RefSeqProteinId","value":"NP_001342206.1"}]},{"database":"AGR","id":"HGNC:31851","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"389857","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CENPVL1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:31851","properties":[{"key":"GeneName","value":"CENPVL1"}]},{"database":"HPA","id":"ENSG00000223591","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (brain)"}]},{"database":"OpenTargets","id":"ENSG00000223591","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000223591","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000003183","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FHAAPRV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10015082at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"A0A0U1RR11","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"Agora","id":"ENSG00000223591","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"Pharos","id":"A0A0U1RR11","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:A0A0U1RR11","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"A0A0U1RR11","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000223591","properties":[{"key":"ExpressionPatterns","value":"Expressed in cortical plate and 19 other cell types or tissues"}]},{"database":"GO","id":"GO:0016846","properties":[{"key":"GoTerm","value":"F:carbon-sulfur lyase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.170.150.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR052355","properties":[{"key":"EntryName","value":"CENP-V-like"}]},{"database":"InterPro","id":"IPR006913","properties":[{"key":"EntryName","value":"CENP-V/GFA"}]},{"database":"InterPro","id":"IPR011057","properties":[{"key":"EntryName","value":"Mss4-like_sf"}]},{"database":"PANTHER","id":"PTHR28620","properties":[{"key":"EntryName","value":"CENTROMERE PROTEIN V"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28620:SF7","properties":[{"key":"EntryName","value":"CENTROMERE PROTEIN V-LIKE PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04828","properties":[{"key":"EntryName","value":"GFA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51316","properties":[{"key":"EntryName","value":"Mss4-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51891","properties":[{"key":"EntryName","value":"CENP_V_GFA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGRVRNRATAQRRRRKRPGDPPAACAAIAVTGASRAQCPRVQVGVGSHAAAKRWLGRWRRKRRWRRVRKAGPRDLLPSAPTPDPPGPAPSPKDLDLGAQRERWETFRKLRGLSCEGAAKVLLDTFEYPGLVHHTGGCHCGAVRFAVWAPADLRVVDCSCRLCRKKQHRHFLVPASRFTLLQGAESIVTYRSNTHPALHSFCSRCGVQSFHAAVSDPRVYGVAPHCLDEGTVRSVVIEEVGGGDPGEEAAEEHKAIHKTSSQSAPACPREQEQ","length":272,"molWeight":29887,"crc64":"46BE2B55BF5CA500","md5":"7572F3DCE5FDD5366D01C6CD372650B4"},"extraAttributes":{"countByCommentType":{"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":3,"Compositional bias":2,"Binding site":7},"uniParcId":"UPI00001D7BC8"}}