{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0A0R4I987","secondaryAccessions":["A0A0H3B164"],"uniProtkbId":"CDII_YERPY","entryAudit":{"firstPublicDate":"2019-05-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-05-08","entryVersion":28,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Yersinia pseudotuberculosis serotype O:3 (strain YPIII)","taxonId":502800,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Yersiniaceae","Yersinia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26449640"}],"value":"Immunity protein CdiI-YPIII"},"shortNames":[{"value":"CdiI-YPIII"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26449640"}],"value":"cdiI"},"orderedLocusNames":[{"value":"YPK_0576"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26449640"}],"value":"Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Neutralizes the toxic activity of cognate toxin CdiA-YPIII (residues 954-1077). Does not inhibit toxic activity of CdiA from other toxin-immunity modules"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26449640"}],"value":"Interacts with the C-terminal DNase fragment (residues 954-1077) of cognate toxin CdiA-YPIII"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26449640"}],"value":"Encoded in a defective cdi locus that has been inactivated by gene rearragements and deletions"}],"commentType":"MISCELLANEOUS"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Immunity protein CdiI-YPIII","featureId":"PRO_0000446874"},{"type":"Beta strand","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Helix","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Helix","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Helix","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Helix","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Beta strand","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]},{"type":"Helix","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZQU"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-D1GOCJBCJ2IQA","citationType":"submission","authoringGroup":["US DOE Joint Genome Institute"],"authors":["Copeland A.","Lucas S.","Lapidus A.","Glavina del Rio T.","Dalin E.","Tice H.","Bruce D.","Goodwin L.","Pitluck S.","Munk A.C.","Brettin T.","Detter J.C.","Han C.","Tapia R.","Schmutz J.","Larimer F.","Land M.","Hauser L.","Challacombe J.F.","Green L.","Lindler L.E.","Nikolich M.P.","Richardson P."],"title":"Complete sequence of Yersinia pseudotuberculosis YPIII.","publicationDate":"FEB-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"YPIII","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"26449640","citationType":"journal article","authors":["Morse R.P.","Willett J.L.","Johnson P.M.","Zheng J.","Credali A.","Iniguez A.","Nowick J.S.","Hayes C.S.","Goulding C.W."],"citationCrossReferences":[{"database":"PubMed","id":"26449640"},{"database":"DOI","id":"10.1016/j.jmb.2015.09.020"}],"title":"Diversification of beta-augmentation interactions between CDI toxin/immunity proteins.","publicationDate":"2015","journal":"J. Mol. Biol.","firstPage":"3766","lastPage":"3784","volume":"427"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) IN COMPLEX WITH CDIA","FUNCTION","SUBUNIT"],"referenceComments":[{"value":"YPIII","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4ZQU"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP000950","properties":[{"key":"ProteinId","value":"ACA66879.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_012303509.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009792.1"}]},{"database":"PDB","id":"4ZQU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"B=1-177"}]},{"database":"PDBsum","id":"4ZQU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"A0A0R4I987","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"A0A0R4I987","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0R4I987","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ypy:YPK_0576","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|502800.11.peg.1189","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EvolutionaryTrace","id":"A0A0R4I987","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd13445","properties":[{"key":"EntryName","value":"CDI_inhibitor_EC869_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1590.10","properties":[{"key":"EntryName","value":"NMB0488-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009888","properties":[{"key":"EntryName","value":"CdiI_Proteobact"}]},{"database":"InterPro","id":"IPR037891","properties":[{"key":"EntryName","value":"Cdil-like_sf"}]},{"database":"Pfam","id":"PF07262","properties":[{"key":"EntryName","value":"CdiI"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF160207","properties":[{"key":"EntryName","value":"NMB0488-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNDIVKSAWASVKMNTDFICVDTYSGYRSNQLDPLGVQHLSSPDVSDLDLGEMVKDALSHSRFVLPAPRTDIWIHPEVTFDLDLYDSRRTVERYDEWVKKLMVHYGYKTKRALFKDMKSCDICCNHDAITISPTRHEKLEVWGGTGLKGSDNVILSVDSSPTEIGAGLRLALSRCKG","length":177,"molWeight":19925,"crc64":"5FA5F4BD40CE1311","md5":"BC220D7224DCBFFDD407A04B94969EDF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"MISCELLANEOUS":1},"countByFeatureType":{"Chain":1,"Beta strand":11,"Helix":5},"uniParcId":"UPI00016DBE4A"}}