{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"A0A087WRU1","uniProtkbId":"RDIC1_MOUSE","entryAudit":{"firstPublicDate":"2024-01-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-10-29","entryVersion":48,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"evidences":[{"evidenceCode":"ECO:0000312","source":"Ensembl","id":"ENSMUSP00000140772.2"},{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000589"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Regulator of DNA class I crossover intermediates 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37604834"}],"value":"Protein CN725425"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37612290"}],"value":"Redic1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37612290"},{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:3613655"}],"value":"CN725425"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37604834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation (PubMed:37604834, PubMed:37612290). Required for normal germline development and fertility (PubMed:37604834, PubMed:37612290). Required for meiotic progression, complete chromosomal synapsis and crossover formation (PubMed:37604834, PubMed:37612290). Binds double-stranded DNA (PubMed:37604834). However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure (PubMed:37612290). Probably not required for formation of DNA double-strand breaks (DSBs) (PubMed:37604834). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs (PubMed:37604834)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"Interacts with MSH5 (PubMed:37612290). Interacts with TEX11 (PubMed:37612290)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"In pachytene spermatocytes, localized along autosomal axes and the synapsed pseudoautosomal region on sex chromosomes, decreasing rapidly after early pachytene, by mid- or late pachytene, and disappearing in the diplotene stage (PubMed:37612290). Also detected on the paired regions of homologous chromosomes in zygotene and pachytene oocytes, colocalizing with MSH4 (PubMed:37612290). Chromosomal localization of REDIC1 is mainly dependent on meiotic DNA double-strand breaks (DSBs) and interhomolog strand invasion (PubMed:37612290). In spermatocytes from early zygotene to early pachytene, more than 90% of REDIC1 foci colocalize with RPA2 (PubMed:37612290). Probably localizes first to recombination intermediates and later colocalizes with MLH1 at crossover sites (PubMed:37612290)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"Chromosome","id":"SL-0468"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37604834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"Expressed mainly in testis (at protein level) (PubMed:37604834). Expressed in spermatogonia and enriched in spermatocytes; absent in testicular somatic cells (at protein level) (PubMed:37604834). No expression or low levels in other tissues (PubMed:37612290)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"Expressed in embryonic ovaries at 14.5 days post-conception (dpc)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37612290"}],"value":"The N-terminal region (residues 1-228) binds branched DNA molecules, such as those containing a D-loop (PubMed:37612290). A truncated N-terminal region (residues 1-78), binds very poorly to similar DNA molecules (PubMed:37612290)"}],"commentType":"DOMAIN"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"Regulator of DNA class I crossover intermediates 1","featureId":"PRO_0000459322"},{"type":"DNA binding","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Binds DNA containing a 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