Q9Y3T9 Q5SVA3 Q9BTN6 NOC2L_HUMAN Nucleolar complex protein 2 homolog Protein NOC2 homolog NOC2-like protein Novel INHAT repressor NOC2L NIR Homo sapiens Human Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. NUCLEOTIDE SEQUENCE [MRNA] FUNCTION IN INHIBITION OF HISTONE ACETYLATION INTERACTION WITH TP53 ASSOCIATION WITH CORE HISTONES AND NUCLEOSOMES Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT VAL-300 Brain The DNA sequence and biological annotation of human chromosome 1. NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT VAL-300 Placenta Functional proteomic analysis of human nucleolus. SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS] Cervix carcinoma Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Cervix carcinoma Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Cervix carcinoma A quantitative atlas of mitotic phosphorylation. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-672; SER-673 AND THR-678 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Cervix carcinoma Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672 AND SER-673 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Leukemic T-cell NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. FUNCTION INTERACTION WITH TP53 AND TP63 SUBCELLULAR LOCATION Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-672 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Cervix carcinoma Initial characterization of the human central proteome. IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. FUNCTION INTERACTION WITH AURKB AND TP53 INDUCTION SUBCELLULAR LOCATION System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-56 AND SER-672 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Toward a comprehensive characterization of a human cancer cell phosphoproteome. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-56; SER-672 AND SER-673 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Cervix carcinoma Erythroleukemia An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-746 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Liver Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes. Q9Y3T9 O15265 false 2 Q9Y3T9 P04637 false 8 Nucleus Nucleoplasm Nucleus Nucleolus Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis. Up-regulated by IL4 and CD40L in B-cells. Belongs to the NOC2 family. 3D-structure Apoptosis Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation A V I V S L R Q K E MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVIVWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License