ID   INSL1_DROME             Reviewed;         154 AA.
AC   Q9VT50;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-SEP-2026, entry version 156.
DE   RecName: Full=Insulin-like peptide 1 {ECO:0000312|FlyBase:FBgn0044051};
DE            Short=dILP1;
DE   AltName: Full=Insulin-related peptide 1;
DE   Contains:
DE     RecName: Full=Insulin-like peptide 1 A chain;
DE   Contains:
DE     RecName: Full=Insulin-like peptide 1 B chain;
DE   Flags: Precursor;
GN   Name=Ilp1 {ECO:0000312|FlyBase:FBgn0044051};
GN   ORFNames=CG14173 {ECO:0000312|FlyBase:FBgn0044051};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=11250149; DOI=10.1016/s0960-9822(01)00068-9;
RA   Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E.;
RT   "An evolutionarily conserved function of the Drosophila insulin receptor
RT   and insulin-like peptides in growth control.";
RL   Curr. Biol. 11:213-221(2001).
CC   -!- FUNCTION: Possible ligand of InR/insulin-like receptor. {ECO:0000305}.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; AE014296; AAF50205.1; -; Genomic_DNA.
DR   RefSeq; NP_648359.1; NM_140102.2.
DR   PDB; 9EF1; EM; 4.40 A; C=30-70, D=128-154.
DR   PDB; 9EF4; EM; 3.90 A; C/E=30-70, D/F=128-154.
DR   AlphaFoldDB; Q9VT50; -.
DR   EMDB; EMD-47967; -.
DR   EMDB; EMD-47969; -.
DR   SMR; Q9VT50; -.
DR   BioGRID; 64537; 2.
DR   FunCoup; Q9VT50; 239.
DR   STRING; 7227.FBpp0076057; -.
DR   PaxDb; 7227-FBpp0076057; -.
DR   DNASU; 39149; -.
DR   EnsemblMetazoa; FBtr0076328; FBpp0076057; FBgn0044051.
DR   GeneID; 39149; -.
DR   KEGG; dme:Dmel_CG14173; -.
DR   AGR; FB:FBgn0044051; -.
DR   CTD; 39149; -.
DR   FlyBase; FBgn0044051; Ilp1.
DR   VEuPathDB; VectorBase:FBgn0044051; -.
DR   eggNOG; ENOG502S3FQ; Eukaryota.
DR   HOGENOM; CLU_1706141_0_0_1; -.
DR   InParanoid; Q9VT50; -.
DR   OMA; VYDECCV; -.
DR   OrthoDB; 10019596at2759; -.
DR   PhylomeDB; Q9VT50; -.
DR   Reactome; R-DME-110478; Insulin signaling pathway.
DR   SignaLink; Q9VT50; -.
DR   BioGRID-ORCS; 39149; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 39149; -.
DR   PRO; PR:Q9VT50; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0044051; Expressed in central nervous system and 3 other cell types or tissues.
DR   ExpressionAtlas; Q9VT50; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; ISS:FlyBase.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR   CDD; cd04366; IlGF_insulin_bombyxin_like; 1.
DR   Gene3D; 1.10.100.10; Insulin-like; 1.
DR   InterPro; IPR022352; Ins/IGF/rlx.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   PANTHER; PTHR13647:SF4; INSULIN-LIKE PEPTIDE 1-RELATED; 1.
DR   PANTHER; PTHR13647; INSULIN-LIKE PEPTIDE 2-RELATED; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; Insulin-like; 1.
DR   PROSITE; PS00262; INSULIN; 1.
DR   PDBsum; 9EF1; -.
DR   PDBsum; 9EF4; -.
PE   1: Evidence at protein level;
KW   3D-structure; Cleavage on pair of basic residues; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..154
FT                   /note="Insulin-like peptide 1"
FT                   /id="PRO_0000016185"
FT   PEPTIDE         30..69
FT                   /note="Insulin-like peptide 1 B chain"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016186"
FT   PROPEP          73..122
FT                   /note="Connecting peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016187"
FT   PEPTIDE         125..154
FT                   /note="Insulin-like peptide 1 A chain"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016188"
FT   REGION          72..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..91
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        49..138
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..151
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        137..142
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   154 AA;  16851 MW;  65E78F17EDC12041 CRC64;
     MFSQHNGAAV HGLRLQSLLI AAMLTAAMAM VTPTGSGHQL LPPGNHKLCG PALSDAMDVV
     CPHGFNTLPR KRESLLGNSD DDEDTEQEVQ DDSSMWQTLD GAGYSFSPLL TNLYGSEVLI
     KMRRHRRHLT GGVYDECCVK TCSYLELAIY CLPK
//