ID   Q9VT21_DROME            Unreviewed;       383 AA.
AC   Q9VT21;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   02-SEP-2026, entry version 208.
DE   SubName: Full=GH06403p {ECO:0000313|EMBL:AAL13532.1};
GN   Name=Cyp40 {ECO:0000313|FlyBase:FBgn0036020};
GN   ORFNames=CG8336 {ECO:0000313|EMBL:AAL13532.1,
GN   ECO:0000313|FlyBase:FBgn0036020};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAL13532.1};
RN   [1] {ECO:0000313|EMBL:AAL13532.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAL13532.1};
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA   Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA   Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA   Rubin G.M., Celniker S.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY058303; AAL13532.1; -; mRNA.
DR   RefSeq; NP_001261636.1; NM_001274707.1.
DR   RefSeq; NP_648338.1; NM_140081.3.
DR   RefSeq; NP_729517.1; NM_168354.2.
DR   RefSeq; NP_729518.1; NM_168355.3.
DR   AlphaFoldDB; Q9VT21; -.
DR   SMR; Q9VT21; -.
DR   IntAct; Q9VT21; 3.
DR   STRING; 7227.FBpp0076113; -.
DR   PaxDb; 7227-FBpp0076113; -.
DR   PeptideAtlas; Q9VT21; -.
DR   DNASU; 39121; -.
DR   GeneID; 39121; -.
DR   KEGG; dme:Dmel_CG8336; -.
DR   UCSC; CG8336-RA; d. melanogaster.
DR   AGR; FB:FBgn0036020; -.
DR   CTD; 39121; -.
DR   FlyBase; FBgn0036020; Cyp40.
DR   VEuPathDB; VectorBase:FBgn0036020; -.
DR   eggNOG; KOG0546; Eukaryota.
DR   HOGENOM; CLU_012062_37_3_1; -.
DR   OMA; EMEQNCN; -.
DR   OrthoDB; 407558at2759; -.
DR   BioGRID-ORCS; 39121; 0 hits in 1 CRISPR screen.
DR   Bgee; FBgn0036020; Expressed in adult posterior midgut class II enteroendocrine cell in adult midgut (Drosophila) and 98 other cell types or tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR   GO; GO:0101031; C:protein folding chaperone complex; IDA:FlyBase.
DR   GO; GO:0016018; F:cyclosporin A binding; IBA:GO_Central.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR   GO; GO:0034587; P:piRNA processing; IMP:FlyBase.
DR   GO; GO:0140991; P:piRNA-mediated gene silencing by mRNA destabilization; IMP:FlyBase.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0070922; P:RISC complex assembly; IGI:FlyBase.
DR   GO; GO:0007283; P:spermatogenesis; IMP:FlyBase.
DR   FunFam; 2.40.100.10:FF:000044; Cyclophilin 40; 1.
DR   Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_rpt.
DR   PANTHER; PTHR11071:SF497; CYCLOPHILIN 40, ISOFORM A; 1.
DR   PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF50891; Cyclophilin-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Isomerase {ECO:0000256|PROSITE-ProRule:PRU00156};
KW   Rotamase {ECO:0000256|PROSITE-ProRule:PRU00156};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          18..182
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50072"
FT   REPEAT          320..353
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          326..380
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   383 AA;  43116 MW;  929D397708BA26E7 CRC64;
     MEERKLLRAV KSTNPLVYLD ISIGKEDAGR MIIELRKDVV PKTAENFRAL CTGECGIGTL
     GKPLHYKGTK FHKIKRVFVV QSGDVVKNDG SSGESIYGPV FDDENFELSH NEEGVVSMAN
     YGKPNSNNSQ FFISAAGCEN LNGTNVVVGR VLRGLGIVAE MEQNCTDEGD PTAPIVIRDC
     GEIAHNEDWG IECNDETTDK LPAYPQDWPR KLDKFTGDGA VELLTGIRQS GNHFYQLGRY
     HEARAKYRKA NRYYHYLSRQ FGWQQLNPLK KHLVDEDLLK VDGFSVVNNI NAAAVDLKVG
     NYTSAREVCN EAIRLDPKCS KAFYRRAQAQ RGLRNYEEAI NDLKTAHNLL PENKQILNEL
     NSTKQLLAQY NRQQRNALKN LFA
//