ID   Q9VM62_DROME            Unreviewed;      1127 AA.
AC   Q9VM62; Q95RF8;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 2.
DT   02-SEP-2026, entry version 191.
DE   SubName: Full=Stromalin 1 {ECO:0000313|EMBL:AAF52463.2};
GN   Name=SA1 {ECO:0000313|EMBL:AAF52463.2,
GN   ECO:0000313|FlyBase:FBgn0020616};
GN   Synonyms=Dmel\CG3423 {ECO:0000313|EMBL:AAF52463.2}, DmSA
GN   {ECO:0000313|EMBL:AAF52463.2}, DSA {ECO:0000313|EMBL:AAF52463.2}, DSA1
GN   {ECO:0000313|EMBL:AAF52463.2}, ESTS:92H2T
GN   {ECO:0000313|EMBL:AAF52463.2}, SA {ECO:0000313|EMBL:AAF52463.2}, SA-1
GN   {ECO:0000313|EMBL:AAF52463.2}, SCC3 {ECO:0000313|EMBL:AAF52463.2},
GN   Scc3 {ECO:0000313|EMBL:AAF52463.2}, stromalin
GN   {ECO:0000313|EMBL:AAF52463.2};
GN   ORFNames=CG3423 {ECO:0000313|EMBL:AAF52463.2,
GN   ECO:0000313|FlyBase:FBgn0020616}, Dmel_CG3423
GN   {ECO:0000313|EMBL:AAF52463.2};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L.,
RA   Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C.,
RA   Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [9] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=26109357; DOI=.1534/g3.115.018929;
RG   FlyBase Consortium;
RA   Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA   Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA   Gelbart W.M., null;
RT   "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT   Throughput Data.";
RL   G3 (Bethesda) 5:1721-1736(2015).
RN   [10] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=26109356; DOI=.1534/g3.115.018937;
RG   FlyBase Consortium;
RA   Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA   Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA   null;
RT   "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL   G3 (Bethesda) 5:1737-1749(2015).
RN   [11] {ECO:0000313|EMBL:AAF52463.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=25589440;
RA   Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA   Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA   Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA   de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA   Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA   Karpen G.H., Celniker S.E.;
RT   "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL   Genome Res. 25:445-458(2015).
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|PROSITE-ProRule:PRU00750}.
CC   -!- SIMILARITY: Belongs to the SCC3 family.
CC       {ECO:0000256|ARBA:ARBA00005486}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014134; AAF52463.2; -; Genomic_DNA.
DR   RefSeq; NP_477268.2; NM_057920.4.
DR   AlphaFoldDB; Q9VM62; -.
DR   SMR; Q9VM62; -.
DR   ComplexPortal; CPX-2780; Nuclear meiotic cohesin complex, C2M-SA variant.
DR   ComplexPortal; CPX-2796; Nuclear mitotic cohesin complex.
DR   IntAct; Q9VM62; 14.
DR   STRING; 7227.FBpp0078977; -.
DR   PaxDb; 7227-FBpp0078977; -.
DR   PeptideAtlas; Q9VM62; -.
DR   DNASU; 33974; -.
DR   GeneID; 33974; -.
DR   KEGG; dme:Dmel_CG3423; -.
DR   UCSC; CG3423-RA; d. melanogaster.
DR   AGR; FB:FBgn0020616; -.
DR   CTD; 33974; -.
DR   FlyBase; FBgn0020616; SA1.
DR   VEuPathDB; VectorBase:FBgn0020616; -.
DR   eggNOG; KOG2011; Eukaryota.
DR   HOGENOM; CLU_005067_0_0_1; -.
DR   OMA; QIQEAAY; -.
DR   OrthoDB; 498590at2759; -.
DR   Reactome; R-DME-2468052; Establishment of Sister Chromatid Cohesion.
DR   Reactome; R-DME-2470946; Cohesin Loading onto Chromatin.
DR   Reactome; R-DME-2500257; Resolution of Sister Chromatid Cohesion.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0020616; Expressed in T neuron T5d (Drosophila) in embryonic/larval optic lobe (Drosophila) and 53 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0008278; C:cohesin complex; IDA:FlyBase.
DR   GO; GO:0000779; C:condensed chromosome, centromeric region; IDA:FlyBase.
DR   GO; GO:0000791; C:euchromatin; IDA:FlyBase.
DR   GO; GO:0030893; C:meiotic cohesin complex; NAS:ComplexPortal.
DR   GO; GO:0030892; C:mitotic cohesin complex; ISS:FlyBase.
DR   GO; GO:0005634; C:nucleus; NAS:ComplexPortal.
DR   GO; GO:0005721; C:pericentric heterochromatin; IDA:FlyBase.
DR   GO; GO:0000922; C:spindle pole; IDA:FlyBase.
DR   GO; GO:0003682; F:chromatin binding; IDA:FlyBase.
DR   GO; GO:0034089; P:establishment of meiotic sister chromatid cohesion; NAS:ComplexPortal.
DR   GO; GO:0034087; P:establishment of mitotic sister chromatid cohesion; NAS:ComplexPortal.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; ISS:FlyBase.
DR   GO; GO:0016322; P:neuron remodeling; IMP:FlyBase.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IMP:FlyBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039662; Cohesin_Scc3/SA.
DR   InterPro; IPR056396; HEAT_SCC3-SA.
DR   InterPro; IPR020839; SCD.
DR   InterPro; IPR013721; STAG.
DR   InterPro; IPR063293; STAG_C.
DR   PANTHER; PTHR11199:SF0; LD34181P-RELATED; 1.
DR   PANTHER; PTHR11199; STROMAL ANTIGEN; 1.
DR   Pfam; PF24571; HEAT_SCC3-SA; 1.
DR   Pfam; PF21581; SCD; 1.
DR   Pfam; PF08514; STAG; 1.
DR   Pfam; PF31007; STAG_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51425; SCD; 1.
PE   1: Evidence at protein level;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00750};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q9VM62};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN          326..411
FT                   /note="SCD"
FT                   /evidence="ECO:0000259|PROSITE:PS51425"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1090..1127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          290..317
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        10..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1108..1121
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1127 AA;  130116 MW;  8DCC0C6934228712 CRC64;
     MMARRGGKRI RMDDPPPDYE ELHSDALNES TSDADSPTKR MTRLRARGGV RDKPPIIDDD
     EDDFFAPIAR KRKTPATRKG PTERKERVER PRKEPVDKGH HERIDSEREI TTDENSLYYI
     VRHSKNPIAS IVDQWIEQYK ANRETALVAL MQFFINASGC KGKISEDIQY PVDHTSIIRR
     MTEEFDEESG EYPLIMSGTQ WRKFKNNFCD FVQTLVKQCQ YSIIYDQFLM DNVISLLTGL
     SDSQVRAFRH TATLAAMKLM TALVDVALLV SNNFDNAAKQ FEAERVKSRD RRASDRLDSL
     MTKRSELEEN MDEIKSMLTY MFKSVFVHRY RDSLPDIRAI CMAEIGIWME NYPQNFLDDS
     YLKYIGWTLH DKIGEVRLRC LQSLLPLYEK DELKGKLELF TSKFKDRIVA MTLDKEFEVS
     VHAVKLVISI LKIHPEILAD KDCEIVYELV YSSHRGVAQA AAEFLNVRLF HLTADMEETK
     TKRGKVRMPN TPLVRDLVQF FIESELHEHG AYLVDSFIDS NDMVRDWECM TDLLLEEPGP
     NEEVLDNKQE STLIEIMVSS VKQSATGEVP VGRASNRKCT LSAKELKAIQ DEKAKLTEHF
     IVTLPSLLEK YQADSEKLAN LLAVPQYFDL NLYTTNRQEG NLQALLDRIN QVMSMHTGRE
     VLETCAKTLE CLCAEGSATY TRCNIARSNI IESAVNKYKD AIEEWRNLIQ GEETPNEDDI
     YNITITLKVL SILYSSHNLN PWELFKSLFQ DVEEAQSKEN IDRCLPNEAL VYCIEACYFS
     ISWGLQYVEN ECESVNVTEV VAELRNNLDT FMGACFELTR DGPTVQIQEA AYQSICDLLI
     IFSDKLARSE IEHIRGLEYK SRMDEHLILD NFVQHYVFSL KQDVAQDETR IEELHKKRNF
     LACYCKLVVY NIIPTMRAAS IFKYYVKCYN DYGDIIKATL GKAREINKVN FAMTLLLSLI
     TVFKSLQEQS EDGIVSKSSQ EFVDLKELAK RFALTFGFDA IKNRESVAAI HRGGIYFAAN
     KEPDDPVRAP TRLLFLEVLN EFNYKLLKQD KKVIMSFLDK IIPPAMPSSR AEEWQPLILY
     RNSLLHGETD QAPVASKRAY TRKRRDHDEE EEEEEDEEEH NDPDYRG
//