ID   D0UGE6_DROME            Unreviewed;      2819 AA.
AC   D0UGE6; Q9VC00;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   02-SEP-2026, entry version 96.
DE   SubName: Full=Tenectin isoform 1 {ECO:0000313|EMBL:ACY36945.1};
DE   SubName: Full=Tenectin isoform 2 {ECO:0000313|EMBL:ACY36944.1};
GN   Name=tnc {ECO:0000313|FlyBase:FBgn0039257};
GN   ORFNames=CG13648 {ECO:0000313|FlyBase:FBgn0039257};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ACY36944.1};
RN   [1] {ECO:0000313|EMBL:ACY36944.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Bouge A.-L., Fraichard S., Kendall T., Bunch T.A., Bouhin H.;
RT   "Tenectin a novel integrin ligand required for wing morphogenesis and male
RT   genital looping in Drosophila.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACY36945.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20152825; DOI=10.1016/j.ydbio.2010.02.008;
RA   Fraichard S., Bouge A.L., Kendall T., Chauvel I., Bouhin H., Bunch T.A.;
RT   "Tenectin is a novel alphaPS2betaPS integrin ligand required for wing
RT   morphogenesis and male genital looping in Drosophila.";
RL   Dev. Biol. 340:504-517(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; GQ507490; ACY36944.1; -; mRNA.
DR   EMBL; GQ507491; ACY36945.1; -; mRNA.
DR   RefSeq; NP_001247300.1; NM_001260371.1.
DR   RefSeq; NP_651318.3; NM_143061.3.
DR   STRING; 7227.FBpp0296947; -.
DR   GlyGen; D0UGE6; 4 sites.
DR   PaxDb; 7227-FBpp0296947; -.
DR   PeptideAtlas; D0UGE6; -.
DR   GeneID; 42990; -.
DR   KEGG; dme:Dmel_CG13648; -.
DR   UCSC; CG13648-RA; d. melanogaster.
DR   AGR; FB:FBgn0039257; -.
DR   CTD; 3371; -.
DR   FlyBase; FBgn0039257; tnc.
DR   VEuPathDB; VectorBase:FBgn0039257; -.
DR   eggNOG; KOG1181; Eukaryota.
DR   HOGENOM; CLU_226564_0_0_1; -.
DR   OMA; KAIIHVD; -.
DR   OrthoDB; 10068079at2759; -.
DR   BioGRID-ORCS; 42990; 0 hits in 1 CRISPR screen.
DR   Bgee; FBgn0039257; Expressed in head cyst cell (Drosophila) in testis and 89 other cell types or tissues.
DR   GO; GO:0031012; C:extracellular matrix; IDA:FlyBase.
DR   GO; GO:0005576; C:extracellular region; IDA:FlyBase.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; ISM:FlyBase.
DR   GO; GO:0048619; P:embryonic hindgut morphogenesis; IMP:FlyBase.
DR   GO; GO:0060562; P:epithelial tube morphogenesis; IMP:FlyBase.
DR   GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase.
DR   GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR   GO; GO:0035296; P:regulation of tube diameter; IMP:FlyBase.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR   InterPro; IPR052424; Kielin_Chordin-BMP_Reg.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR46698; CROSSVEINLESS 2; 1.
DR   PANTHER; PTHR46698:SF3; TENECTIN ISOFORM 1-RELATED; 1.
DR   SMART; SM00214; VWC; 4.
DR   SUPFAM; SSF57603; FnI-like domain; 6.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   2: Evidence at transcript level;
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..2819
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015088127"
FT   DOMAIN          233..301
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   REGION          342..1104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1181..2656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..550
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..575
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..613
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..796
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..869
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        870..882
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..925
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        935..945
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        969..986
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1064..1075
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1076..1086
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1190..1201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1237..1251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1252..1307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1316..1331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1351..1360
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1371..1383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1409..1420
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1461..1471
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1513..1524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1557..1574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1611..1635
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1812..1828
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1852..1871
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1895..1905
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1908..1926
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1974..1988
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2012..2029
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2032..2046
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2135..2144
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2160..2174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2175..2185
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2199..2219
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2406..2423
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2432..2509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2520..2534
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2535..2555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2610..2633
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2819 AA;  299608 MW;  F4FCFD8EE0819D6C CRC64;
     MTRRRSSPPG LEELLYLALV LLAMILIPTQ AAPVQEYTEI QQYSEGCYYN YAHYQEGDRI
     MTNEPCLNCT CHNRMLMCYL RVCPFTKPIG HDCIVEKRED QCCPIITCPE VPVDVPYHSP
     EPGTELSIPE KFGCSIEEKF YPEGAQVPSN PNKPCELCYC INNQTKCVMQ ECTLHVDGCL
     PIYNKGSCCP VRYSCDHENE LDFMDQSTTT TTTTVRPTTG FILASTMTPP TTTDCIHDGE
     IFADGASLKG KNACEHCYCM RGDIVCAVQE CEVPMMAANG KSCRAMPAAE GECCPSNYVC
     EDDSSTTEIV EITTPESATS VPAKGIHAEI PKEDVDLQEH IDDDDKNKET ATIPSAELGS
     GEIEEEEEEK DKATTVAPVQ VTDEKDFSFE PESSTAGIPS DSRIDLPSST EESKESSTEA
     AEEDIVKIVT TPEPEGSGEE DVPKPSQIPE KEITEDELIK VSTSAPAKAS PEEEVVTATT
     SAPTEEDVKP TTAGTISEEE EEGKPTPAEE GSGEEEKDVK VTAAPEETED EAKPTSAPVA
     SDEKEQEPKP SEGSGDEELD LKPTTAPTAG ATSASEESEE QDEGKSTEAP TSVDDIEPAK
     PTESSEEASG EGEDVAKETT PAGEASIAGE EEIVKGTTPA GEPSSEGDEE IVKGTTPAEE
     SSSESEDELT KVTTPAGEPS VAGEEEIAKE TTPAGEPSIA GEEEIVKVTT PAGESSIAGE
     EEIVKVTTPA GESSSEGEEE IIKVTTPAGE SSSEGDEEIV KESTPAGEPI SEGEEDVIKA
     TTSAPKSDIE GVKEPETATE VPAEEVEDFA KPTTPIAEAE EEPIAGTPIP TDGISGEEEI
     VKGTTPQTLE EQPEISEEST EVPVAEDDLS SSTSASAIAS STEGVQDAAS ETTSSAPARA
     GDKDEAATTV PTAQDKDDEE VEQDATDLPV EDVVQSTTAK TTTTEQPKEE SSTEAEDAEI
     EVTTSSPADK QEVPEAEPAD KDHKDEEDVQ TATDLPIKSD IGPPVVDTEA TTGQPETSDE
     TATDKPPSVY LPPGGEKDTE KEDETTATEP SVQEEPSKPV DISPVSQEVP SSTAKVDNRN
     DFETEKPTLP PSGEDQSSEP LPAMDLPAGI PGEGDCLVEG KTYANNTIVP ATAPCDVSCK
     CISSLVACQQ MECKLPENLE KCTVAADLLD GCCPTYICDE STESAEKDEE STAKPDNKID
     EDVSEISTEE IPKDVIMPTG ITEQPLSHVK PDEEIQPVTS VPAQFDESTT AKVDKKPIDE
     SAEDKKPIGE SEEDSKPIDE SEEDKKPVEE SAEDKKPVED SEEKEKPLPT VIPASEIEKE
     SKPEDEKKTE ADFAAPTEQP EATTPAQIAD TAEKEVDDKL ATTSAPVSGE DELKPADEKK
     RTETAQIPDA EIPASTDEPE SSTELPTVDL DKKPEEDSTK GTEAPESDKV PEVPTSASTE
     NEIEESDKFT TVAPPKISAS DETEPTAEED LVPATFEPIE SEFEVSTKKP AVQGPPLPTL
     APAQPEKKPV DAETSTEADI STEPSAEVEK EASGETSESD NEIDAGASST PVPVSADEDK
     TPSTEKTVEA DDKFTTVAPL AGDEEESNLP KLPQDIFEEE APVAVTTAAP SKDDGEQKPV
     EVEEKPIEDG QKPIEDETST PTSSENEIEP ESDRATTIAP SKEEPSEPST GAPTKDEPAE
     PSTDAPESDE SKETPESEVP TTVAPAGEKI PTSSITPDEE PTATSAPVAK PDEDVEKETS
     TEIPTDAPAS SEEDENSSTD QIPSEVPEKK PETPAQTPEE GDIVGATAAP TTSDEVPPVQ
     RLPEEVLAEI PQPSTETGIK QQDETTAAPS IDRKEPYVTE IDEEATTVAP ISEKDEKPTE
     EEKPVEQKPT GEEPSEEEEK EKPIEQDVST EGPVSTEASE AGSTESSEEV KPSTEGEVAE
     KPEDKQPSST AQAPVETIPE ISTELPAQDG DKPTSEAPVD SDEDTSAPSD EKIPSVSGEE
     VEGPEVTTAS PQAAEEDELK TPAESEPSST DKVPETEYQK PEDETKADET PESVTQVSDV
     ATSTSAPVAG GDIEKDEQAT TASPEEEEEI KPTIAPAAEI PQPSEKEPVD EQEVESGTKA
     TPAESDGQPI DEIAPATSGP IDEASTAAPT KEESTTVASA ASPAVHDDEI KDVTTTQPVA
     DEKEVAAPQD ETKTSIDVST DSPTAQDDEK QDKTEAPVAP TTVSSPTADS AADSSTPTVE
     VPSPVEIDTK PMDDIMSQTI APHTADGAAS TSTEDEDQAP VTVSPQDAEK TPVSPAPQDS
     DKTPSSEAPQ DADEIPATAT PLDDNKIPAT VAPQTDDGVP ATAAPLDEDK IQTTAAPLDE
     EKIPSTAAPL DDEKIPAPVS PVVFDVEPSS EKPAVSEYDG EESTEPPVHD VETSTDEPTS
     DAKLKPPTSA PATPSESPAT EAEIVPETAA PELEKEVPEK ATEQPELEKE TPEKATEQPE
     LEKETPEKAT EQPELEKETP EKATEQPELE KEVTDKATEQ PESVDEKTTP EPVVKPSLDS
     TEEDEESVES EEESADKKDK NKETEEDTDK KHEEPEVPAV VSEIPQPSEE AVPTTGHPLF
     PHLASSTTTP PAVDDRVGEE DEENTTVKLS SSTTTSTTES PVTSAPSTTT VASQQQQPIT
     PPPYGHAPEY EDEYDEEEVF GPGTCRYAGK LYVSAQQIPR DDPCDFCFCF RSDIICLQQS
     CPPPIAGCHE EPISGFCCPR YECPVSMAAV LNITTSTTTT STTLPPHFLH YSHGEAVKHT
     GCLINGRSYR VGEQIESTSG PCISCTCGGD GKMKCDPQQC VPEPTMQQVM AAVVSGRKR
//