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  <accession>Q9V9T9</accession>
  <name>Q9V9T9_DROME</name>
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    <recommendedName>
      <fullName evidence="6 12">Beta-glucuronidase</fullName>
      <ecNumber evidence="5 12">3.2.1.31</ecNumber>
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  </protein>
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    <name evidence="17 18" type="primary">betaGlu</name>
    <name evidence="17" type="synonym">beta-GUS</name>
    <name evidence="17" type="synonym">Dmel\CG2135</name>
    <name evidence="17" type="synonym">Glc</name>
    <name evidence="17" type="synonym">Glu</name>
    <name evidence="17" type="synonym">gus</name>
    <name evidence="17 18" type="ORF">CG2135</name>
    <name evidence="17" type="ORF">Dmel_CG2135</name>
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    <name type="scientific">Drosophila melanogaster</name>
    <name type="common">Fruit fly</name>
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      <taxon>Metazoa</taxon>
      <taxon>Ecdysozoa</taxon>
      <taxon>Arthropoda</taxon>
      <taxon>Altocrustacea</taxon>
      <taxon>Allotriocarida</taxon>
      <taxon>Hexapoda</taxon>
      <taxon>Insecta</taxon>
      <taxon>Pterygota</taxon>
      <taxon>Neoptera</taxon>
      <taxon>Eumetabola</taxon>
      <taxon>Endopterygota</taxon>
      <taxon>Aparaglossata</taxon>
      <taxon>Panorpida</taxon>
      <taxon>Diptera</taxon>
      <taxon>Brachycera</taxon>
      <taxon>Muscomorpha</taxon>
      <taxon>Ephydroidea</taxon>
      <taxon>Drosophilidae</taxon>
      <taxon>Drosophila</taxon>
      <taxon>Sophophora</taxon>
    </lineage>
  </organism>
  <reference evidence="17 19" key="1">
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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      <strain evidence="19">Berkeley</strain>
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    <scope>GENOME REANNOTATION</scope>
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      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain evidence="19">Berkeley</strain>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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      <strain evidence="19">Berkeley</strain>
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  <comment type="function">
    <text evidence="1 12">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="12">
      <text>a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
      <dbReference type="Rhea" id="RHEA:17633"/>
      <dbReference type="ChEBI" id="CHEBI:15377"/>
      <dbReference type="ChEBI" id="CHEBI:30879"/>
      <dbReference type="ChEBI" id="CHEBI:58720"/>
      <dbReference type="ChEBI" id="CHEBI:83411"/>
      <dbReference type="EC" id="3.2.1.31"/>
    </reaction>
  </comment>
  <comment type="activity regulation">
    <text evidence="12">Inhibited by L-aspartic acid.</text>
  </comment>
  <comment type="subunit">
    <text evidence="4 12">Homotetramer.</text>
  </comment>
  <comment type="subcellular location">
    <subcellularLocation>
      <location evidence="2">Lysosome</location>
    </subcellularLocation>
  </comment>
  <comment type="similarity">
    <text evidence="3 12">Belongs to the glycosyl hydrolase 2 family.</text>
  </comment>
  <dbReference type="EC" id="3.2.1.31" evidence="5 12"/>
  <dbReference type="EMBL" id="AE014297">
    <property type="protein sequence ID" value="AAF57195.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="NP_651893.1">
    <property type="nucleotide sequence ID" value="NM_143636.3"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q9V9T9"/>
  <dbReference type="SMR" id="Q9V9T9"/>
  <dbReference type="IntAct" id="Q9V9T9">
    <property type="interactions" value="1"/>
  </dbReference>
  <dbReference type="STRING" id="7227.FBpp0085217"/>
  <dbReference type="PaxDb" id="7227-FBpp0085217"/>
  <dbReference type="PeptideAtlas" id="Q9V9T9"/>
  <dbReference type="DNASU" id="43746"/>
  <dbReference type="GeneID" id="43746"/>
  <dbReference type="KEGG" id="dme:Dmel_CG2135"/>
  <dbReference type="UCSC" id="CG2135-RA">
    <property type="organism name" value="d. melanogaster"/>
  </dbReference>
  <dbReference type="AGR" id="FB:FBgn0270927"/>
  <dbReference type="CTD" id="43746"/>
  <dbReference type="FlyBase" id="FBgn0270927">
    <property type="gene designation" value="betaGlu"/>
  </dbReference>
  <dbReference type="VEuPathDB" id="VectorBase:FBgn0270927"/>
  <dbReference type="eggNOG" id="KOG2024">
    <property type="taxonomic scope" value="Eukaryota"/>
  </dbReference>
  <dbReference type="HOGENOM" id="CLU_006501_6_1_1"/>
  <dbReference type="OMA" id="IHDHVGW"/>
  <dbReference type="OrthoDB" id="408532at2759"/>
  <dbReference type="BioGRID-ORCS" id="43746">
    <property type="hits" value="0 hits in 1 CRISPR screen"/>
  </dbReference>
  <dbReference type="Proteomes" id="UP000000803">
    <property type="component" value="Chromosome 3R"/>
  </dbReference>
  <dbReference type="Bgee" id="FBgn0270927">
    <property type="expression patterns" value="Expressed in adult middle midgut class II enteroendocrine cell in adult midgut (Drosophila) and 62 other cell types or tissues"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005576">
    <property type="term" value="C:extracellular region"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005764">
    <property type="term" value="C:lysosome"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0016020">
    <property type="term" value="C:membrane"/>
    <property type="evidence" value="ECO:0000314"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0004566">
    <property type="term" value="F:beta-glucuronidase activity"/>
    <property type="evidence" value="ECO:0000314"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0030246">
    <property type="term" value="F:carbohydrate binding"/>
    <property type="evidence" value="ECO:0000318"/>
    <property type="project" value="GO_Central"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005975">
    <property type="term" value="P:carbohydrate metabolic process"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0030207">
    <property type="term" value="P:chondroitin sulfate proteoglycan catabolic process"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0030200">
    <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="FunFam" id="2.60.120.260:FF:000027">
    <property type="entry name" value="Beta-glucuronidase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="2.60.40.10:FF:000628">
    <property type="entry name" value="Beta-glucuronidase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.20.20.80:FF:000029">
    <property type="entry name" value="Beta-glucuronidase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="2.60.120.260">
    <property type="entry name" value="Galactose-binding domain-like"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.20.20.80">
    <property type="entry name" value="Glycosidases"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="2.60.40.10">
    <property type="entry name" value="Immunoglobulins"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR036156">
    <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR008979">
    <property type="entry name" value="Galactose-bd-like_sf"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR017853">
    <property type="entry name" value="GH_hydrolase_sf"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR006101">
    <property type="entry name" value="Glyco_hydro_2"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR006103">
    <property type="entry name" value="Glyco_hydro_2_cat"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR023230">
    <property type="entry name" value="Glyco_hydro_2_CS"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR006104">
    <property type="entry name" value="Glyco_hydro_2_N"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR013783">
    <property type="entry name" value="Ig-like_fold"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR006102">
    <property type="entry name" value="Ig-like_GH2"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR10066">
    <property type="entry name" value="BETA-GLUCURONIDASE"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR10066:SF67">
    <property type="entry name" value="BETA-GLUCURONIDASE"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF00703">
    <property type="entry name" value="Glyco_hydro_2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF02836">
    <property type="entry name" value="Glyco_hydro_2_C"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF02837">
    <property type="entry name" value="Glyco_hydro_2_N"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PRINTS" id="PR00132">
    <property type="entry name" value="GLHYDRLASE2"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF51445">
    <property type="entry name" value="(Trans)glycosidases"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF49303">
    <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF49785">
    <property type="entry name" value="Galactose-binding domain-like"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS00719">
    <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="evidence at protein level"/>
  <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
  <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
  <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
  <keyword evidence="10 12" id="KW-0458">Lysosome</keyword>
  <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
  <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
  <keyword evidence="7 13" id="KW-0732">Signal</keyword>
  <feature type="signal peptide" evidence="13">
    <location>
      <begin position="1"/>
      <end position="21"/>
    </location>
  </feature>
  <feature type="chain" id="PRO_5015100075" description="Beta-glucuronidase" evidence="13">
    <location>
      <begin position="22"/>
      <end position="686"/>
    </location>
  </feature>
  <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="16">
    <location>
      <begin position="109"/>
      <end position="245"/>
    </location>
  </feature>
  <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="14">
    <location>
      <begin position="248"/>
      <end position="361"/>
    </location>
  </feature>
  <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="15">
    <location>
      <begin position="367"/>
      <end position="660"/>
    </location>
  </feature>
  <evidence type="ECO:0000256" key="1">
    <source>
      <dbReference type="ARBA" id="ARBA00003025"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="2">
    <source>
      <dbReference type="ARBA" id="ARBA00004371"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="3">
    <source>
      <dbReference type="ARBA" id="ARBA00007401"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="4">
    <source>
      <dbReference type="ARBA" id="ARBA00011881"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="5">
    <source>
      <dbReference type="ARBA" id="ARBA00012761"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="6">
    <source>
      <dbReference type="ARBA" id="ARBA00016205"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="7">
    <source>
      <dbReference type="ARBA" id="ARBA00022729"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="8">
    <source>
      <dbReference type="ARBA" id="ARBA00022801"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="9">
    <source>
      <dbReference type="ARBA" id="ARBA00023180"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="10">
    <source>
      <dbReference type="ARBA" id="ARBA00023228"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="11">
    <source>
      <dbReference type="ARBA" id="ARBA00023295"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="12">
    <source>
      <dbReference type="RuleBase" id="RU361154"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="13">
    <source>
      <dbReference type="SAM" id="SignalP"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="14">
    <source>
      <dbReference type="Pfam" id="PF00703"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="15">
    <source>
      <dbReference type="Pfam" id="PF02836"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="16">
    <source>
      <dbReference type="Pfam" id="PF02837"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="17">
    <source>
      <dbReference type="EMBL" id="AAF57195.1"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="18">
    <source>
      <dbReference type="FlyBase" id="FBgn0270927"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="19">
    <source>
      <dbReference type="Proteomes" id="UP000000803"/>
    </source>
  </evidence>
  <evidence type="ECO:0007829" key="20">
    <source>
      <dbReference type="PeptideAtlas" id="Q9V9T9"/>
    </source>
  </evidence>
  <sequence length="686" mass="79302" checksum="570CAFBF0D92E022" modified="2000-05-01" version="1">MKSHWMPVTCLLLGSLQVLLAYTENDFLVNANRKELTDSPLFEYDNVRKPTPTKGLLYPRDSETREVRSLDGMWQLVRSDPYDPLQGIREKWFMDALRKTGREIISMPVPASYNDITTDNLRDHVGTVWYERTFFVPRSWKTMQRTWLRFSSVHYSAVVWINGRNATSHSIGHLPFESEISGLLSFGGDNRITVMCDNRLSNRTIPQGSVYKVATDDGTVPIQSYTFDFFNYAGIHRSVHLYTTPLLHISDLEVTTQLTKEGLGRIDYRVWLDASKEGLQIQPIQLRVQLRDKDGHVAAQQINKAVYHGTLLVPNATPWWPYLMHSDPGYLYNLQFELFVASNEKELESLQDTYRLPVGIRSLSWDNDSLLLNGKPLYLRGFGRHEDSDIRGKGLDNALLARDFNLLKWTGANAYRTSHYPYSEESMQFADQHGIMIIDECPAVNIDIFEPQLLENHMSSLEQLIHRDRNHPSVVAWSVANEPRSNKQGALKYFEFLVNYVREIAHGRPLTAAINANSSSCHLAQFLDIVGFNRYNSWYQNSGRTDMILNLLTIEAQSWRDRFGKPVIQFEYGGDTMEGMHSLPAFIWSEEYQVELFSRHFKAFDELRGRGWFIGEFVWNFADFRTAQTITRVGGNKKGVFTRNRQPKEVAHILRRRYFALAKELDMFGLPEDLTVYISKHIHNEL</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>