<?xml version="1.0" encoding="UTF-8"  standalone="no" ?>
<uniprot xmlns="http://uniprot.org/uniprot" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2026-09-02" version="174" xmlns="http://uniprot.org/uniprot">
  <accession>Q9V3T9</accession>
  <name>ADRO_DROME</name>
  <protein>
    <recommendedName>
      <fullName>NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
      <shortName>AR</shortName>
      <shortName>Adrenodoxin reductase</shortName>
      <ecNumber>1.18.1.6</ecNumber>
    </recommendedName>
    <alternativeName>
      <fullName>Ferredoxin--NADP(+) reductase</fullName>
      <shortName>Ferredoxin reductase</shortName>
    </alternativeName>
  </protein>
  <gene>
    <name type="primary">dare</name>
    <name type="ORF">CG12390</name>
  </gene>
  <organism>
    <name type="scientific">Drosophila melanogaster</name>
    <name type="common">Fruit fly</name>
    <dbReference type="NCBI Taxonomy" id="7227"/>
    <lineage>
      <taxon>Eukaryota</taxon>
      <taxon>Metazoa</taxon>
      <taxon>Ecdysozoa</taxon>
      <taxon>Arthropoda</taxon>
      <taxon>Altocrustacea</taxon>
      <taxon>Allotriocarida</taxon>
      <taxon>Hexapoda</taxon>
      <taxon>Insecta</taxon>
      <taxon>Pterygota</taxon>
      <taxon>Neoptera</taxon>
      <taxon>Eumetabola</taxon>
      <taxon>Endopterygota</taxon>
      <taxon>Aparaglossata</taxon>
      <taxon>Panorpida</taxon>
      <taxon>Diptera</taxon>
      <taxon>Brachycera</taxon>
      <taxon>Muscomorpha</taxon>
      <taxon>Ephydroidea</taxon>
      <taxon>Drosophilidae</taxon>
      <taxon>Drosophila</taxon>
      <taxon>Sophophora</taxon>
    </lineage>
  </organism>
  <reference key="1">
    <citation type="journal article" date="1999" name="Development" volume="126" first="4591" last="4602">
      <title>The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila.</title>
      <authorList>
        <person name="Freeman M.R."/>
        <person name="Dobritsa A."/>
        <person name="Gaines P."/>
        <person name="Segraves W.A."/>
        <person name="Carlson J.R."/>
      </authorList>
      <dbReference type="PubMed" id="10498693"/>
      <dbReference type="DOI" id="10.1242/dev.126.20.4591"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    <scope>FUNCTION</scope>
    <scope>TISSUE SPECIFICITY</scope>
    <source>
      <strain>W1118</strain>
      <tissue>Head</tissue>
      <tissue>Testis</tissue>
    </source>
  </reference>
  <reference key="2">
    <citation type="journal article" date="2000" name="Science" volume="287" first="2185" last="2195">
      <title>The genome sequence of Drosophila melanogaster.</title>
      <authorList>
        <person name="Adams M.D."/>
        <person name="Celniker S.E."/>
        <person name="Holt R.A."/>
        <person name="Evans C.A."/>
        <person name="Gocayne J.D."/>
        <person name="Amanatides P.G."/>
        <person name="Scherer S.E."/>
        <person name="Li P.W."/>
        <person name="Hoskins R.A."/>
        <person name="Galle R.F."/>
        <person name="George R.A."/>
        <person name="Lewis S.E."/>
        <person name="Richards S."/>
        <person name="Ashburner M."/>
        <person name="Henderson S.N."/>
        <person name="Sutton G.G."/>
        <person name="Wortman J.R."/>
        <person name="Yandell M.D."/>
        <person name="Zhang Q."/>
        <person name="Chen L.X."/>
        <person name="Brandon R.C."/>
        <person name="Rogers Y.-H.C."/>
        <person name="Blazej R.G."/>
        <person name="Champe M."/>
        <person name="Pfeiffer B.D."/>
        <person name="Wan K.H."/>
        <person name="Doyle C."/>
        <person name="Baxter E.G."/>
        <person name="Helt G."/>
        <person name="Nelson C.R."/>
        <person name="Miklos G.L.G."/>
        <person name="Abril J.F."/>
        <person name="Agbayani A."/>
        <person name="An H.-J."/>
        <person name="Andrews-Pfannkoch C."/>
        <person name="Baldwin D."/>
        <person name="Ballew R.M."/>
        <person name="Basu A."/>
        <person name="Baxendale J."/>
        <person name="Bayraktaroglu L."/>
        <person name="Beasley E.M."/>
        <person name="Beeson K.Y."/>
        <person name="Benos P.V."/>
        <person name="Berman B.P."/>
        <person name="Bhandari D."/>
        <person name="Bolshakov S."/>
        <person name="Borkova D."/>
        <person name="Botchan M.R."/>
        <person name="Bouck J."/>
        <person name="Brokstein P."/>
        <person name="Brottier P."/>
        <person name="Burtis K.C."/>
        <person name="Busam D.A."/>
        <person name="Butler H."/>
        <person name="Cadieu E."/>
        <person name="Center A."/>
        <person name="Chandra I."/>
        <person name="Cherry J.M."/>
        <person name="Cawley S."/>
        <person name="Dahlke C."/>
        <person name="Davenport L.B."/>
        <person name="Davies P."/>
        <person name="de Pablos B."/>
        <person name="Delcher A."/>
        <person name="Deng Z."/>
        <person name="Mays A.D."/>
        <person name="Dew I."/>
        <person name="Dietz S.M."/>
        <person name="Dodson K."/>
        <person name="Doup L.E."/>
        <person name="Downes M."/>
        <person name="Dugan-Rocha S."/>
        <person name="Dunkov B.C."/>
        <person name="Dunn P."/>
        <person name="Durbin K.J."/>
        <person name="Evangelista C.C."/>
        <person name="Ferraz C."/>
        <person name="Ferriera S."/>
        <person name="Fleischmann W."/>
        <person name="Fosler C."/>
        <person name="Gabrielian A.E."/>
        <person name="Garg N.S."/>
        <person name="Gelbart W.M."/>
        <person name="Glasser K."/>
        <person name="Glodek A."/>
        <person name="Gong F."/>
        <person name="Gorrell J.H."/>
        <person name="Gu Z."/>
        <person name="Guan P."/>
        <person name="Harris M."/>
        <person name="Harris N.L."/>
        <person name="Harvey D.A."/>
        <person name="Heiman T.J."/>
        <person name="Hernandez J.R."/>
        <person name="Houck J."/>
        <person name="Hostin D."/>
        <person name="Houston K.A."/>
        <person name="Howland T.J."/>
        <person name="Wei M.-H."/>
        <person name="Ibegwam C."/>
        <person name="Jalali M."/>
        <person name="Kalush F."/>
        <person name="Karpen G.H."/>
        <person name="Ke Z."/>
        <person name="Kennison J.A."/>
        <person name="Ketchum K.A."/>
        <person name="Kimmel B.E."/>
        <person name="Kodira C.D."/>
        <person name="Kraft C.L."/>
        <person name="Kravitz S."/>
        <person name="Kulp D."/>
        <person name="Lai Z."/>
        <person name="Lasko P."/>
        <person name="Lei Y."/>
        <person name="Levitsky A.A."/>
        <person name="Li J.H."/>
        <person name="Li Z."/>
        <person name="Liang Y."/>
        <person name="Lin X."/>
        <person name="Liu X."/>
        <person name="Mattei B."/>
        <person name="McIntosh T.C."/>
        <person name="McLeod M.P."/>
        <person name="McPherson D."/>
        <person name="Merkulov G."/>
        <person name="Milshina N.V."/>
        <person name="Mobarry C."/>
        <person name="Morris J."/>
        <person name="Moshrefi A."/>
        <person name="Mount S.M."/>
        <person name="Moy M."/>
        <person name="Murphy B."/>
        <person name="Murphy L."/>
        <person name="Muzny D.M."/>
        <person name="Nelson D.L."/>
        <person name="Nelson D.R."/>
        <person name="Nelson K.A."/>
        <person name="Nixon K."/>
        <person name="Nusskern D.R."/>
        <person name="Pacleb J.M."/>
        <person name="Palazzolo M."/>
        <person name="Pittman G.S."/>
        <person name="Pan S."/>
        <person name="Pollard J."/>
        <person name="Puri V."/>
        <person name="Reese M.G."/>
        <person name="Reinert K."/>
        <person name="Remington K."/>
        <person name="Saunders R.D.C."/>
        <person name="Scheeler F."/>
        <person name="Shen H."/>
        <person name="Shue B.C."/>
        <person name="Siden-Kiamos I."/>
        <person name="Simpson M."/>
        <person name="Skupski M.P."/>
        <person name="Smith T.J."/>
        <person name="Spier E."/>
        <person name="Spradling A.C."/>
        <person name="Stapleton M."/>
        <person name="Strong R."/>
        <person name="Sun E."/>
        <person name="Svirskas R."/>
        <person name="Tector C."/>
        <person name="Turner R."/>
        <person name="Venter E."/>
        <person name="Wang A.H."/>
        <person name="Wang X."/>
        <person name="Wang Z.-Y."/>
        <person name="Wassarman D.A."/>
        <person name="Weinstock G.M."/>
        <person name="Weissenbach J."/>
        <person name="Williams S.M."/>
        <person name="Woodage T."/>
        <person name="Worley K.C."/>
        <person name="Wu D."/>
        <person name="Yang S."/>
        <person name="Yao Q.A."/>
        <person name="Ye J."/>
        <person name="Yeh R.-F."/>
        <person name="Zaveri J.S."/>
        <person name="Zhan M."/>
        <person name="Zhang G."/>
        <person name="Zhao Q."/>
        <person name="Zheng L."/>
        <person name="Zheng X.H."/>
        <person name="Zhong F.N."/>
        <person name="Zhong W."/>
        <person name="Zhou X."/>
        <person name="Zhu S.C."/>
        <person name="Zhu X."/>
        <person name="Smith H.O."/>
        <person name="Gibbs R.A."/>
        <person name="Myers E.W."/>
        <person name="Rubin G.M."/>
        <person name="Venter J.C."/>
      </authorList>
      <dbReference type="PubMed" id="10731132"/>
      <dbReference type="DOI" id="10.1126/science.287.5461.2185"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain>Berkeley</strain>
    </source>
  </reference>
  <reference key="3">
    <citation type="journal article" date="2002" name="Genome Biol." volume="3" first="RESEARCH0083.1" last="RESEARCH0083.22">
      <title>Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.</title>
      <authorList>
        <person name="Misra S."/>
        <person name="Crosby M.A."/>
        <person name="Mungall C.J."/>
        <person name="Matthews B.B."/>
        <person name="Campbell K.S."/>
        <person name="Hradecky P."/>
        <person name="Huang Y."/>
        <person name="Kaminker J.S."/>
        <person name="Millburn G.H."/>
        <person name="Prochnik S.E."/>
        <person name="Smith C.D."/>
        <person name="Tupy J.L."/>
        <person name="Whitfield E.J."/>
        <person name="Bayraktaroglu L."/>
        <person name="Berman B.P."/>
        <person name="Bettencourt B.R."/>
        <person name="Celniker S.E."/>
        <person name="de Grey A.D.N.J."/>
        <person name="Drysdale R.A."/>
        <person name="Harris N.L."/>
        <person name="Richter J."/>
        <person name="Russo S."/>
        <person name="Schroeder A.J."/>
        <person name="Shu S.Q."/>
        <person name="Stapleton M."/>
        <person name="Yamada C."/>
        <person name="Ashburner M."/>
        <person name="Gelbart W.M."/>
        <person name="Rubin G.M."/>
        <person name="Lewis S.E."/>
      </authorList>
      <dbReference type="PubMed" id="12537572"/>
      <dbReference type="DOI" id="10.1186/gb-2002-3-12-research0083"/>
    </citation>
    <scope>GENOME REANNOTATION</scope>
    <source>
      <strain>Berkeley</strain>
    </source>
  </reference>
  <comment type="function">
    <text evidence="4">Required for synthesis of steroid hormones, for olfactory sensory behavior and completion of the second larval molt (a steroid mediated developmental transition) and pupariation.</text>
  </comment>
  <comment type="catalytic activity">
    <reaction>
      <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
      <dbReference type="Rhea" id="RHEA:42312"/>
      <dbReference type="Rhea" id="RHEA-COMP:9998"/>
      <dbReference type="Rhea" id="RHEA-COMP:9999"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:33737"/>
      <dbReference type="ChEBI" id="CHEBI:33738"/>
      <dbReference type="ChEBI" id="CHEBI:57783"/>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
      <dbReference type="EC" id="1.18.1.6"/>
    </reaction>
  </comment>
  <comment type="cofactor">
    <cofactor>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </cofactor>
  </comment>
  <comment type="pathway">
    <text evidence="1">Steroid metabolism.</text>
  </comment>
  <comment type="subcellular location">
    <subcellularLocation>
      <location evidence="2">Mitochondrion inner membrane</location>
      <topology evidence="5">Peripheral membrane protein</topology>
    </subcellularLocation>
  </comment>
  <comment type="tissue specificity">
    <text evidence="4">Expressed predominantly in prothoracic gland of the larval ring gland and nurse cells of the adult ovary. Low expression in all adult tissues examined.</text>
  </comment>
  <comment type="similarity">
    <text evidence="5">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
  </comment>
  <dbReference type="EC" id="1.18.1.6"/>
  <dbReference type="EMBL" id="AF168685">
    <property type="protein sequence ID" value="AAD50819.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="EMBL" id="AE013599">
    <property type="protein sequence ID" value="AAF58678.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="NP_477150.1">
    <property type="nucleotide sequence ID" value="NM_057802.6"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q9V3T9"/>
  <dbReference type="SMR" id="Q9V3T9"/>
  <dbReference type="BioGRID" id="61998">
    <property type="interactions" value="2"/>
  </dbReference>
  <dbReference type="FunCoup" id="Q9V3T9">
    <property type="interactions" value="1549"/>
  </dbReference>
  <dbReference type="STRING" id="7227.FBpp0087272"/>
  <dbReference type="GlyGen" id="Q9V3T9">
    <property type="glycosylation" value="1 site"/>
  </dbReference>
  <dbReference type="PaxDb" id="7227-FBpp0087272"/>
  <dbReference type="PeptideAtlas" id="Q9V3T9"/>
  <dbReference type="DNASU" id="36203"/>
  <dbReference type="EnsemblMetazoa" id="FBtr0088176">
    <property type="protein sequence ID" value="FBpp0087272"/>
    <property type="gene ID" value="FBgn0015582"/>
  </dbReference>
  <dbReference type="GeneID" id="36203"/>
  <dbReference type="KEGG" id="dme:Dmel_CG12390"/>
  <dbReference type="AGR" id="FB:FBgn0015582"/>
  <dbReference type="CTD" id="36203"/>
  <dbReference type="FlyBase" id="FBgn0015582">
    <property type="gene designation" value="dare"/>
  </dbReference>
  <dbReference type="VEuPathDB" id="VectorBase:FBgn0015582"/>
  <dbReference type="eggNOG" id="KOG1800">
    <property type="taxonomic scope" value="Eukaryota"/>
  </dbReference>
  <dbReference type="HOGENOM" id="CLU_024722_3_1_1"/>
  <dbReference type="InParanoid" id="Q9V3T9"/>
  <dbReference type="OMA" id="RFNFIGN"/>
  <dbReference type="OrthoDB" id="333024at2759"/>
  <dbReference type="PhylomeDB" id="Q9V3T9"/>
  <dbReference type="Reactome" id="R-DME-2395516">
    <property type="pathway name" value="Electron transport from NADPH to Ferredoxin"/>
  </dbReference>
  <dbReference type="BioGRID-ORCS" id="36203">
    <property type="hits" value="2 hits in 3 CRISPR screens"/>
  </dbReference>
  <dbReference type="GenomeRNAi" id="36203"/>
  <dbReference type="PRO" id="PR:Q9V3T9"/>
  <dbReference type="Proteomes" id="UP000000803">
    <property type="component" value="Chromosome 2R"/>
  </dbReference>
  <dbReference type="Bgee" id="FBgn0015582">
    <property type="expression patterns" value="Expressed in adult enteroendocrine precursor cell in adult midgut (Drosophila) and 62 other cell types or tissues"/>
  </dbReference>
  <dbReference type="ExpressionAtlas" id="Q9V3T9">
    <property type="expression patterns" value="baseline and differential"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005743">
    <property type="term" value="C:mitochondrial inner membrane"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="UniProtKB"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005759">
    <property type="term" value="C:mitochondrial matrix"/>
    <property type="evidence" value="ECO:0000303"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005739">
    <property type="term" value="C:mitochondrion"/>
    <property type="evidence" value="ECO:0000314"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0004324">
    <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0008203">
    <property type="term" value="P:cholesterol metabolic process"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniPathway"/>
  </dbReference>
  <dbReference type="GO" id="GO:0016226">
    <property type="term" value="P:iron-sulfur cluster assembly"/>
    <property type="evidence" value="ECO:0000303"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0007552">
    <property type="term" value="P:metamorphosis"/>
    <property type="evidence" value="ECO:0000315"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0006694">
    <property type="term" value="P:steroid biosynthetic process"/>
    <property type="evidence" value="ECO:0000314"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="GO" id="GO:0006744">
    <property type="term" value="P:ubiquinone biosynthetic process"/>
    <property type="evidence" value="ECO:0000250"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="FunFam" id="3.50.50.60:FF:000229">
    <property type="entry name" value="NADPH:adrenodoxin oxidoreductase, mitochondrial"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.50.50.60">
    <property type="entry name" value="FAD/NAD(P)-binding domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.40.50.720">
    <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR036188">
    <property type="entry name" value="FAD/NAD-bd_sf"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR055275">
    <property type="entry name" value="Ferredox_Rdtase"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR021163">
    <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR48467">
    <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR48467:SF1">
    <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF13450">
    <property type="entry name" value="NAD_binding_8"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PIRSF" id="PIRSF000362">
    <property type="entry name" value="FNR"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PRINTS" id="PR00419">
    <property type="entry name" value="ADXRDTASE"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF51971">
    <property type="entry name" value="Nucleotide-binding domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="evidence at transcript level"/>
  <keyword id="KW-0249">Electron transport</keyword>
  <keyword id="KW-0274">FAD</keyword>
  <keyword id="KW-0285">Flavoprotein</keyword>
  <keyword id="KW-0472">Membrane</keyword>
  <keyword id="KW-0496">Mitochondrion</keyword>
  <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
  <keyword id="KW-0521">NADP</keyword>
  <keyword id="KW-0560">Oxidoreductase</keyword>
  <keyword id="KW-1185">Reference proteome</keyword>
  <keyword id="KW-0809">Transit peptide</keyword>
  <keyword id="KW-0813">Transport</keyword>
  <feature type="transit peptide" description="Mitochondrion" evidence="3">
    <location>
      <begin position="1"/>
      <end status="unknown"/>
    </location>
  </feature>
  <feature type="chain" id="PRO_0000019424" description="NADPH:adrenodoxin oxidoreductase, mitochondrial">
    <location>
      <begin status="unknown"/>
      <end position="466"/>
    </location>
  </feature>
  <feature type="binding site">
    <location>
      <position position="40"/>
    </location>
    <ligand>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </ligand>
  </feature>
  <feature type="binding site">
    <location>
      <position position="61"/>
    </location>
    <ligand>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </ligand>
  </feature>
  <feature type="binding site">
    <location>
      <position position="69"/>
    </location>
    <ligand>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </ligand>
  </feature>
  <feature type="binding site">
    <location>
      <position position="105"/>
    </location>
    <ligand>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <begin position="176"/>
      <end position="179"/>
    </location>
    <ligand>
      <name>NADP(+)</name>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <begin position="220"/>
      <end position="221"/>
    </location>
    <ligand>
      <name>NADP(+)</name>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="232"/>
    </location>
    <ligand>
      <name>NADP(+)</name>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
    </ligand>
  </feature>
  <feature type="binding site">
    <location>
      <position position="379"/>
    </location>
    <ligand>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </ligand>
  </feature>
  <feature type="binding site">
    <location>
      <begin position="386"/>
      <end position="388"/>
    </location>
    <ligand>
      <name>FAD</name>
      <dbReference type="ChEBI" id="CHEBI:57692"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="386"/>
    </location>
    <ligand>
      <name>NADP(+)</name>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
    </ligand>
  </feature>
  <evidence type="ECO:0000250" key="1">
    <source>
      <dbReference type="UniProtKB" id="P08165"/>
    </source>
  </evidence>
  <evidence type="ECO:0000250" key="2">
    <source>
      <dbReference type="UniProtKB" id="P48360"/>
    </source>
  </evidence>
  <evidence type="ECO:0000255" key="3"/>
  <evidence type="ECO:0000269" key="4">
    <source>
      <dbReference type="PubMed" id="10498693"/>
    </source>
  </evidence>
  <evidence type="ECO:0000305" key="5"/>
  <sequence length="466" mass="51353" checksum="64D7C1FF0F1CAFD6" modified="2000-05-01" version="1" precursor="true">MGINCLNIFRRGLHTSSARLQVIQSTTPTKRICIVGAGPAGFYAAQLILKQLDNCVVDVVEKLPVPFGLVRFGVAPDHPEVKNVINTFTKTAEHPRLRYFGNISLGTDVSLRELRDRYHAVLLTYGADQDRQLELENEQLDNVISARKFVAWYNGLPGAENLAPDLSGRDVTIVGQGNVAVDVARMLLSPLDALKTTDTTEYALEALSCSQVERVHLVGRRGPLQAAFTIKELREMLKLPNVDTRWRTEDFSGIDMQLDKLQRPRKRLTELMLKSLKEQGRISGSKQFLPIFLRAPKAIAPGEMEFSVTELQQEAAVPTSSTERLPSHLILRSIGYKSSCVDTGINFDTRRGRVHNINGRILKDDATGEVDPGLYVAGWLGTGPTGVIVTTMNGAFAVAKTICDDINTNALDTSSVKPGYDADGKRVVTWDGWQRINDFESAAGKAKGKPREKIVSIEEMLRVAGV</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>