ID   IQEC3_HUMAN             Reviewed;        1182 AA.
AC   Q9UPP2; A6NIF2; A6NKV9; Q8TB43;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   04-NOV-2026, entry version 183.
DE   RecName: Full=IQ motif and SEC7 domain-containing protein 3;
GN   Name=IQSEC3; Synonyms=KIAA1110;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-1182 (ISOFORM 1), AND VARIANT
RP   GLY-558.
RC   TISSUE=Brain;
RX   PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA   Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIV. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 6:197-205(1999).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=17981261; DOI=10.1016/j.bbrc.2007.10.041;
RA   Hattori Y., Ohta S., Hamada K., Yamada-Okabe H., Kanemura Y., Matsuzaki Y.,
RA   Okano H., Kawakami Y., Toda M.;
RT   "Identification of a neuron-specific human gene, KIAA1110, that is a
RT   guanine nucleotide exchange factor for ARF1.";
RL   Biochem. Biophys. Res. Commun. 364:737-742(2007).
CC   -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
CC       {ECO:0000269|PubMed:17981261}.
CC   -!- SUBUNIT: Interacts with DLG1 and DLG4 (By similarity). Interacts with
CC       GPHN (By similarity). {ECO:0000250|UniProtKB:Q3TES0,
CC       ECO:0000250|UniProtKB:Q76M68}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17981261}.
CC       Postsynaptic density {ECO:0000250|UniProtKB:Q3TES0}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UPP2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UPP2-2; Sequence=VSP_035695, VSP_035696, VSP_035697;
CC   -!- TISSUE SPECIFICITY: Expressed specifically in the adult brain,
CC       predominantly in the cerebral cortex and the olfactory bulb, but not in
CC       the fetal brain. Expressed only in mature neurons, but not in
CC       undifferentiated neural stem precursor cells (NSPCs), nor in glioma
CC       cells. {ECO:0000269|PubMed:17981261}.
CC   -!- SIMILARITY: Belongs to the BRAG family. {ECO:0000305}.
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DR   EMBL; AK091953; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC007406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC024764; AAH24764.1; -; mRNA.
DR   EMBL; BC042067; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AB029033; BAA83062.1; -; mRNA.
DR   CCDS; CCDS31725.1; -. [Q9UPP2-2]
DR   CCDS; CCDS53728.1; -. [Q9UPP2-1]
DR   RefSeq; NP_001164209.1; NM_001170738.2. [Q9UPP2-1]
DR   RefSeq; NP_056047.1; NM_015232.2. [Q9UPP2-2]
DR   AlphaFoldDB; Q9UPP2; -.
DR   SMR; Q9UPP2; -.
DR   BioGRID; 136270; 3.
DR   FunCoup; Q9UPP2; 593.
DR   IntAct; Q9UPP2; 1.
DR   STRING; 9606.ENSP00000437554; -.
DR   GlyCosmos; Q9UPP2; 2 sites, 1 glycan.
DR   GlyGen; Q9UPP2; 2 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9UPP2; -.
DR   PhosphoSitePlus; Q9UPP2; -.
DR   BioMuta; IQSEC3; -.
DR   DMDM; 215274117; -.
DR   jPOST; Q9UPP2; -.
DR   MassIVE; Q9UPP2; -.
DR   PaxDb; 9606-ENSP00000437554; -.
DR   PeptideAtlas; Q9UPP2; -.
DR   ProteomicsDB; 85398; -. [Q9UPP2-1]
DR   ProteomicsDB; 85399; -. [Q9UPP2-2]
DR   Antibodypedia; 50062; 68 antibodies from 16 providers.
DR   DNASU; 440073; -.
DR   Ensembl; ENST00000382841.2; ENSP00000372292.2; ENSG00000120645.12. [Q9UPP2-2]
DR   Ensembl; ENST00000538872.6; ENSP00000437554.1; ENSG00000120645.12. [Q9UPP2-1]
DR   Ensembl; ENST00000571363.2; ENSP00000461043.1; ENSG00000262607.5. [Q9UPP2-2]
DR   GeneID; 440073; -.
DR   KEGG; hsa:440073; -.
DR   MANE-Select; ENST00000538872.6; ENSP00000437554.1; NM_001170738.2; NP_001164209.1.
DR   UCSC; uc001qhu.2; human. [Q9UPP2-1]
DR   AGR; HGNC:29193; -.
DR   ClinPGx; PA134990290; -.
DR   CTD; 440073; -.
DR   DisGeNET; 440073; -.
DR   GeneCards; IQSEC3; -.
DR   HGNC; HGNC:29193; IQSEC3.
DR   HPA; ENSG00000120645; Tissue enriched (brain).
DR   MIM; 612118; gene.
DR   OpenTargets; ENSG00000120645; -.
DR   VEuPathDB; HostDB:ENSG00000120645; -.
DR   eggNOG; KOG0931; Eukaryota.
DR   GeneTree; ENSGT00940000155908; -.
DR   HOGENOM; CLU_004328_2_0_1; -.
DR   InParanoid; Q9UPP2; -.
DR   OMA; AAGKAEX; -.
DR   OrthoDB; 430364at2759; -.
DR   PAN-GO; Q9UPP2; 4 GO annotations based on evolutionary models.
DR   PhylomeDB; Q9UPP2; -.
DR   PathwayCommons; Q9UPP2; -.
DR   Reactome; R-HSA-9768919; NPAS4 regulates expression of target genes.
DR   SignaLink; Q9UPP2; -.
DR   Agora; ENSG00000120645; -.
DR   BioGRID-ORCS; 440073; 10 hits in 1152 CRISPR screens.
DR   CD-CODE; FB4E32DD; Presynaptic clusters and postsynaptic densities.
DR   ChiTaRS; IQSEC3; human.
DR   GenomeRNAi; 440073; -.
DR   Pharos; Q9UPP2; Tbio.
DR   PRO; PR:Q9UPP2; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9UPP2; protein.
DR   Bgee; ENSG00000120645; Expressed in right hemisphere of cerebellum and 137 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0060077; C:inhibitory synapse; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   GO; GO:0099149; P:regulation of postsynaptic neurotransmitter receptor internalization; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14686; bZIP; 1.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   FunFam; 1.10.1000.11:FF:000001; IQ motif and SEC7 domain-containing protein 1; 1.
DR   FunFam; 1.10.220.20:FF:000001; IQ motif and SEC7 domain-containing protein 1; 1.
DR   FunFam; 2.30.29.30:FF:000096; IQ motif and SEC7 domain-containing protein 3; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF318; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW   Proteomics identification; Reference proteome; Synapse.
FT   CHAIN           1..1182
FT                   /note="IQ motif and SEC7 domain-containing protein 3"
FT                   /id="PRO_0000245610"
FT   DOMAIN          315..344
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          644..837
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   DOMAIN          850..983
FT                   /note="PH"
FT   REGION          62..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1002..1090
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1121..1182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          20..56
FT                   /evidence="ECO:0000255"
FT   COILED          964..992
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        63..78
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..105
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..263
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..548
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..569
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..581
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..616
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1022..1033
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1043..1052
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1061..1087
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1121..1132
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1147..1157
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         259
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TES0"
FT   VAR_SEQ         1..303
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_035695"
FT   VAR_SEQ         1040..1062
FT                   /note="SIHNRLQTSQHNSGLGAERGAPV -> LINASPARLTILPISRDTIKSYC
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_035696"
FT   VAR_SEQ         1063..1182
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_035697"
FT   VARIANT         558
FT                   /note="A -> G (in dbSNP:rs56204927)"
FT                   /evidence="ECO:0000269|PubMed:10470851"
FT                   /id="VAR_061789"
FT   CONFLICT        31
FT                   /note="T -> S (in Ref. 3; AAH24764)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        283
FT                   /note="P -> S (in Ref. 3; BC042067)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        397
FT                   /note="E -> K (in Ref. 1; AK091953)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        465
FT                   /note="D -> G (in Ref. 4; BAA83062)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        476
FT                   /note="A -> T (in Ref. 1; AK091953)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        514
FT                   /note="Q -> H (in Ref. 1; AK091953)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1182 AA;  127621 MW;  CA03171E62C19E07 CRC64;
     MESLLENPVR AVLYLKELTA IVQNQQSLIH TQRERIDELE RRLDELSAEN RSLWEHQQLL
     QAQPPPGLVP PSSAPLPAAP ATAPAAAARA QEPLQDQGQR SAAAPHPAPD RPPRQHHGQL
     LEQPQRGPGS RAHTPQSPHK HLGTQGAVTD KEKERPPSCC AAAGALLQHK SPSALGKGVL
     SRRPENETVL HQFCCPAADA CSDLASQSDG SCTQAGGGME DSVVAAAAVA AGRPSAHAPK
     AQAQELQEEE ERPGAGAASP RAGPQHKASP GRQQPALATA LCPHAPAASD YELSLDLKNK
     QIEMLEHKYG GHLVSRRAAC TIQTAFRQYQ LSKNFEKIRN SLLESRLPRR ISLRKVRSPT
     AESLAAEKAL MEGYGLVGLP LVRSPSLPPT FAGTLTELED SFTEQVQSLA KSIDDALSTW
     SLKTMCSLRE SGAYQLHQAL QAAAGPPGLE AEGRAPESAG PGPGDDAAET PGLPPAHSGT
     LMMAFRDVTV QIANQNISVS SSTALSVANC LGAQTVQAPA EPAAGKAEQG ETSGREAPEA
     PAVGREDASA EDSCAEAAAS GAADGATAPK TEEEEEEEET AEVGRGAEAE AGDLEQLSSS
     STSTKSAKSG SEASASASKD ALQAMILSLP RYHCENPASC KSPTLSTDTL RKRLYRIGLN
     LFNINPDKGI QFLISRGFIP DTPIGVAHFL LQRKGLSRQM IGEFLGNSKK QFNRDVLDCV
     VDEMDFSSME LDEALRKFQA HIRVQGEAQK VERLIEAFSQ RYCMCNPEVV QQFHNPDTIF
     ILAFAIILLN TDMYSPNIKP DRKMMLEDFI RNLRGVDDGA DIPRELVVGI YERIQQKELK
     SNEDHVTYVT KVEKSIVGMK TVLSVPHRRL VCCSRLFEVT DVNKLQKQAA HQREVFLFND
     LLVILKLCPK KKSSSTYTFC KSVGLLGMQF QLFENEYYSH GITLVTPLSG SEKKQVLHFC
     ALGSDEMQKF VEDLKESIAE VTELEQIRIE WELEKQQGTK TLSFKPCGAQ GDPQSKQGSP
     TAKREAALRE RPAESTVEVS IHNRLQTSQH NSGLGAERGA PVPPPDLQPS PPRQQTPPLP
     PPPPTPPGTL VQCQQIVKVI VLDKPCLARM EPLLSQALSC YTSSSSDSCG STPLGGPGSP
     VKVTHQPPLP PPPPPYNHPH QFCPPGSLLH GHRYSSGSRS LV
//