##gff-version 3 Q9UK23 UniProtKB Signal peptide 1 25 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12058031;Dbxref=PMID:12058031 Q9UK23 UniProtKB Propeptide 26 49 . . . ID=PRO_0000424659;Note=Removed in mature form Q9UK23 UniProtKB Chain 50 515 . . . ID=PRO_0000021788;Note=N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Q9UK23 UniProtKB Topological domain 50 448 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Transmembrane 449 469 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Topological domain 470 515 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Domain 358 390 . . . Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 Q9UK23 UniProtKB Region 486 493 . . . Note=Mediates the interaction with AP4M1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544806;Dbxref=PMID:26544806 Q9UK23 UniProtKB Motif 488 491 . . . Note=Tyrosine-based internalization motif Q9UK23 UniProtKB Motif 511 515 . . . Note=NPF internalization motif Q9UK23 UniProtKB Glycosylation 208 208 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Glycosylation 214 214 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Glycosylation 296 296 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Glycosylation 366 366 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Glycosylation 388 388 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Glycosylation 420 420 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UK23 UniProtKB Disulfide bond 115 148 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Disulfide bond 132 323 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00076,ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Disulfide bond 307 314 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Disulfide bond 362 373 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 Q9UK23 UniProtKB Disulfide bond 380 389 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 Q9UK23 UniProtKB Alternative sequence 307 309 . . . ID=VSP_012267;Note=In isoform 3. CQD->WQA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9UK23 UniProtKB Alternative sequence 310 515 . . . ID=VSP_012268;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9UK23 UniProtKB Alternative sequence 392 425 . . . ID=VSP_012269;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10551838;Dbxref=PMID:10551838 Q9UK23 UniProtKB Natural variant 84 84 . . . ID=VAR_073225;Note=Rare variant%3B found in individuals suffering from stuttering%3B uncertain significance. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20147709;Dbxref=dbSNP:rs755458782,PMID:20147709 Q9UK23 UniProtKB Natural variant 328 328 . . . ID=VAR_073226;Note=Rare variant%3B found in individuals suffering from stuttering%3B uncertain significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20147709;Dbxref=dbSNP:rs139526942,PMID:20147709 Q9UK23 UniProtKB Natural variant 465 465 . . . ID=VAR_020609;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10551838;Dbxref=dbSNP:rs7188856,PMID:10551838 Q9UK23 UniProtKB Mutagenesis 51 51 . . . Note=65%25 of wild-type of activity. C->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 115 115 . . . Note=15%25 of wild-type of activity%2C and almost no traffic to Golgi. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 132 132 . . . Note=No traffic to Golgi. C->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 137 137 . . . Note=11%25 of wild-type of activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 221 221 . . . Note=10%25 of wild-type of activity%3B when associated with M-51. C->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 225 225 . . . Note=6%25 of wild-type of activity. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 227 227 . . . Note=Complete loss of activity. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 247 247 . . . Note=87%25 of wild-type of activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 284 284 . . . Note=22%25 of wild-type of activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 286 286 . . . Note=Complete loss of activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 287 287 . . . Note=16%25 of wild-type of activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 288 288 . . . Note=Complete loss of activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 289 289 . . . Note=Complete loss of activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 290 290 . . . Note=Complete loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 320 320 . . . Note=43%25 of wild-type of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 322 322 . . . Note=67%25 of wild-type of activity. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23572527;Dbxref=PMID:23572527 Q9UK23 UniProtKB Mutagenesis 486 486 . . . Note=Interaction with AP4M1 is abolished. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544806;Dbxref=PMID:26544806 Q9UK23 UniProtKB Mutagenesis 488 488 . . . Note=Interaction with AP4M1 is abolished. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544806;Dbxref=PMID:26544806 Q9UK23 UniProtKB Mutagenesis 491 491 . . . Note=Interaction with AP4M1 is abolished. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26544806;Dbxref=PMID:26544806 Q9UK23 UniProtKB Sequence conflict 259 259 . . . Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9UK23 UniProtKB Sequence conflict 405 405 . . . Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305