ID   Q9TP17_MOUSE            Unreviewed;       238 AA.
AC   Q9TP17;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 4.
DT   04-NOV-2026, entry version 138.
DE   SubName: Full=MHC class II antigen beta chain {ECO:0000313|EMBL:AAF21604.4};
DE   Flags: Precursor; Fragment;
GN   Name=Rmcs1 {ECO:0000313|EMBL:AAF21604.4};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAF21604.4};
RN   [1] {ECO:0000313|EMBL:AAF21604.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:AAF21604.4};
RC   TISSUE=Tail {ECO:0000313|EMBL:AAF21604.4};
RX   PubMed=11451415; DOI=10.1016/S0161-5890(01)00029-3;
RA   Liu Y., McMinimy D.L., Savinov A.Y., Johnson K.A., Kremlev S.G.,
RA   Chapoval A.I., Egorov I.K.;
RT   "Hidden variables: unstable Abeta chain genes encoding antigen recognition
RT   structures in tumor survivors.";
RL   Mol. Immunol. 37:1091-1110(2000).
RN   [2] {ECO:0000313|EMBL:AAF21604.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:AAF21604.4};
RC   TISSUE=Tail {ECO:0000313|EMBL:AAF21604.4};
RA   Savinov A.Y., Liu Y., McMinimy D.L., Johnson K.A., Egorov I.K.;
RT   "Cloning and expression of mouse Rmcs1, Rmcs2 and Rmcs5 genes: a candidate
RT   immune suppression complex.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|ARBA:ARBA00007394}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00114}.
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DR   EMBL; AF015280; AAF21604.4; -; Genomic_DNA.
DR   AlphaFoldDB; Q9TP17; -.
DR   SMR; Q9TP17; -.
DR   GlyCosmos; Q9TP17; 1 site, No reported glycans.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:InterPro.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd21001; IgC1_MHC_II_beta_HLA-DQ_I-A; 1.
DR   FunFam; 2.60.40.10:FF:000116; HLA class II histocompatibility antigen, DRB1-1 beta chain; 1.
DR   FunFam; 3.10.320.10:FF:000001; HLA class II histocompatibility antigen, DRB1-1 beta chain; 1.
DR   Gene3D; 3.10.320.10; Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR050160; MHC/Immunoglobulin.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   PANTHER; PTHR19944:SF101; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin domain {ECO:0000256|PROSITE-ProRule:PRU00114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          98..186
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF21604.4"
SQ   SEQUENCE   238 AA;  27449 MW;  3B78EB4EE35BF56B CRC64;
     GDSERHFVYQ FMGECYFTNG TQRIRYVTRY IYNREEYVRY DSDVGEHRAV TELGRPDAEY
     WNSQPEILER TRAELDTVCR HNYEGPETHT SLRRLEQPNV VISLSRTEAL NHHNTLVCSV
     TDFYPAKIKV RWFRNGQEET VGVSSTQLIR NGDWTFQVLV MLEMTPRRGE VYTCHVEHPS
     LKSPITVEWR AQSESAWSKM LSGIGGCVLG VIFLGLGLFI RHRSQKGPRG PPPAGLLQ
//