ID   TCX6_ARATH              Reviewed;         571 AA.
AC   Q9SL70; F4IUE5; Q8GUZ0; Q8GUZ1; Q8GUZ2;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-SEP-2026, entry version 140.
DE   RecName: Full=Protein tesmin/TSO1-like CXC 6;
DE            Short=AtTCX6;
GN   Name=TCX6; OrderedLocusNames=At2g20110; ORFNames=T2G17.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Resource (TAIR);
RT   "Community-consensus reference genome of Arabidopsis thaliana Col-0.";
RL   Submitted (FEB-2026) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA   Takagi M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-571 (ISOFORMS 1; 2 AND 3).
RC   STRAIN=cv. Columbia;
RX   PubMed=12481096; DOI=10.1104/pp.010207;
RA   Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT   "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT   of Arabidopsis.";
RL   Plant Physiol. 130:2118-2128(2002).
RN   [6]
RP   GENE FAMILY, NOMENCLATURE, ZINC-BINDING, AND TISSUE SPECIFICITY.
RX   PubMed=18057042; DOI=10.1093/jxb/erm215;
RA   Andersen S.U., Algreen-Petersen R.G., Hoedl M., Jurkiewicz A.,
RA   Cvitanich C., Braunschweig U., Schauser L., Oh S.A., Twell D., Jensen E.O.;
RT   "The conserved cysteine-rich domain of a tesmin/TSO1-like protein binds
RT   zinc in vitro and TSO1 is required for both male and female fertility in
RT   Arabidopsis thaliana.";
RL   J. Exp. Bot. 58:3657-3670(2007).
CC   -!- FUNCTION: Plays a role in development of both male and female
CC       reproductive tissues. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9SL70; Q9LM76: PUB44; NbExp=3; IntAct=EBI-1238421, EBI-4466572;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9SL70-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9SL70-2; Sequence=VSP_044004;
CC       Name=3;
CC         IsoId=Q9SL70-3; Sequence=VSP_044003;
CC   -!- TISSUE SPECIFICITY: Ubiquitous but expressed mostly in flowers.
CC       {ECO:0000269|PubMed:18057042}.
CC   -!- DOMAIN: The cysteine-rich domain CRC binds zinc in vitro.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC       site. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice
CC       site. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the lin-54 family. {ECO:0000305}.
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DR   EMBL; AC006081; AAD24386.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06966.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06967.1; -; Genomic_DNA.
DR   EMBL; OZ408684; CAO7035623.1; -; Genomic_DNA.
DR   EMBL; AB493556; BAH30394.1; -; mRNA.
DR   EMBL; AY163773; AAN85197.1; -; mRNA.
DR   EMBL; AY163774; AAN85198.1; -; mRNA.
DR   EMBL; AY163775; AAN85199.1; -; mRNA.
DR   PIR; B84585; B84585.
DR   RefSeq; NP_179601.1; NM_127569.3. [Q9SL70-1]
DR   RefSeq; NP_849995.1; NM_179664.2. [Q9SL70-2]
DR   AlphaFoldDB; Q9SL70; -.
DR   SMR; Q9SL70; -.
DR   BioGRID; 1884; 11.
DR   FunCoup; Q9SL70; 28.
DR   IntAct; Q9SL70; 9.
DR   STRING; 3702.Q9SL70; -.
DR   iPTMnet; Q9SL70; -.
DR   PaxDb; 3702-Q9SL70; -.
DR   ProteomicsDB; 234379; -. [Q9SL70-1]
DR   GeneID; 816530; -.
DR   KEGG; ath:AT2G20110; -.
DR   Araport; AT2G20110; -.
DR   TAIR; AT2G20110; -.
DR   eggNOG; KOG1171; Eukaryota.
DR   InParanoid; Q9SL70; -.
DR   PhylomeDB; Q9SL70; -.
DR   PRO; PR:Q9SL70; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SL70; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISM:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   InterPro; IPR005172; CRC.
DR   InterPro; IPR028307; Lin-54_fam.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   PANTHER; PTHR12446:SF34; PROTEIN LIN-54 HOMOLOG; 1.
DR   PANTHER; PTHR12446; TESMIN/TSO1-RELATED; 1.
DR   Pfam; PF03638; TCR; 2.
DR   SMART; SM01114; CXC; 2.
DR   PROSITE; PS51634; CRC; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Developmental protein; Metal-binding; Nucleus;
KW   Reference proteome; Zinc.
FT   CHAIN           1..571
FT                   /note="Protein tesmin/TSO1-like CXC 6"
FT                   /id="PRO_0000418171"
FT   DOMAIN          117..241
FT                   /note="CRC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00971"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          92..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..557
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         331..334
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:12481096"
FT                   /id="VSP_044003"
FT   VAR_SEQ         475
FT                   /note="K -> KVFCLFVA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12481096"
FT                   /id="VSP_044004"
FT   CONFLICT        520
FT                   /note="N -> T (in Ref. 5; AAN85197/AAN85198/AAN85199)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   571 AA;  61313 MW;  36701C5FA62B3B89 CRC64;
     MGEGEEGDKF PPKTDEVTQE SMKSARQLDF TGGSSDVEHS HSNQASSMAA ASIPSPIVTV
     TRPIITSQAP PTVATPIPPP PQSQGIILHV PIRHPRPESP NSMPRPAGET RDGTPQKKKQ
     CNCKHSRCLK LYCECFASGT YCDGCNCVNC FNNVENEPAR RQAVESTLER NPNAFRPKIA
     ASPHGGRDNR EEVGDVVMLA RHNKGCHCKK SGCLKKYCEC FQANILCSEN CKCLDCKNFE
     GSEVRQSLFH GEHSHNLAYL QHANAAITGA IGSSGFASAP PPKRRKGQEI FFNQGTKDSS
     THRLGQANNG RTTSSQTGSR AGGNASLGPS KVVYKSLLAN IIKPMDVKAL CSVLVAVAGE
     AAKTLTEKRL ANQKETSVAS SVQDQGHVNN KAEKSGLEDS NADGSKGRSL SPETLALMCD
     ERDTMLMVAA SPNCSVEPTS QLPNGQDQVY AEQEKVVLTK FRDCLNRIIS CGEVKESNCS
     MSRMDLDTPV QTTVRIDPVV QQAPVANGVS QTAKQPSQLN TTTPNTSSQT ANGVSQTAKQ
     PSQLTTTTTT PNTSSQTHLH KTPALSEKKD L
//