Q9R1T9 O89048 KCNH4_RAT Voltage-gated delayed rectifier potassium channel KCNH4 Brain-specific eag-like channel 2 BEC2 Ether-a-go-go-like potassium channel 1 ELK channel 1 rElk1 Potassium voltage-gated channel subfamily H member 4 Voltage-gated potassium channel subunit Kv12.3 Kcnh4 Elk1 Elk3 Rattus norvegicus Rat Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus NUCLEOTIDE SEQUENCE [MRNA] FUNCTION TRANSPORTER ACTIVITY TISSUE SPECIFICITY Brain cortex NUCLEOTIDE SEQUENCE [MRNA] Brain TISSUE SPECIFICITY Pore-forming (alpha) subunit of a voltage-gated delayed rectifier (PubMed:9824707). Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation (PubMed:9824707). K(+)(in) = K(+)(out) The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Membrane Multi-pass membrane protein Highly expressed in adult testis, and in adult and embryonic brain (PubMed:9824707). In adult brain found in piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus (PubMed:11425889). Detected at intermediate levels in lung, spinal cord, and pituitary (PubMed:9824707). Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily. Coiled coil Glycoprotein Ion channel Ion transport Membrane Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel R W MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNELGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNNHENSLGRRGASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVKANSNVFEPKPSVPEYKVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVVSAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDNTVLAILGKGDLIGADIPELGQEPGAGAGCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYVAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGMEPGAGSKPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGSSPSLHGPPRGSAAWKPPQLLTPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQAPLSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLGPPSHPPDSTWLPDLPCPHQRPPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSELRSSMVPPFPSEPDPLGPSPVPEASPLTPSLLKHSFQSGSDTFH Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License