ID   Q9K044_NEIMB            Unreviewed;       424 AA.
AC   Q9K044;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   04-NOV-2026, entry version 104.
DE   SubName: Full=Uroporphyrin-III C-methyltransferase HemX {ECO:0000313|EMBL:AAF41191.1};
GN   OrderedLocusNames=NMB0778 {ECO:0000313|EMBL:AAF41191.1};
OS   Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF41191.1, ECO:0000313|Proteomes:UP000000425};
RN   [1] {ECO:0000313|EMBL:AAF41191.1, ECO:0000313|Proteomes:UP000000425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-335 / MC58 {ECO:0000313|Proteomes:UP000000425};
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA   White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA   Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
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DR   EMBL; AE002098; AAF41191.1; -; Genomic_DNA.
DR   PIR; G81160; G81160.
DR   AlphaFoldDB; Q9K044; -.
DR   FunCoup; Q9K044; 143.
DR   STRING; 122586.NMB0778; -.
DR   PaxDb; 122586-NMB0778; -.
DR   KEGG; nme:NMB0778; -.
DR   PATRIC; fig|122586.8.peg.985; -.
DR   HOGENOM; CLU_036381_3_0_4; -.
DR   InParanoid; Q9K044; -.
DR   OMA; AAIRTYK; -.
DR   OrthoDB; 9787650at2; -.
DR   Proteomes; UP000000425; Chromosome.
DR   InterPro; IPR007470; HemX.
DR   PANTHER; PTHR38043; PROTEIN HEMX; 1.
DR   PANTHER; PTHR38043:SF1; PROTEIN HEMX; 1.
DR   Pfam; PF04375; HemX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000425};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          358..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..371
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  46319 MW;  728266A5CC1D730A CRC64;
     MPSETSSPRK ENETEVHIPA APFIVKQSGS NALAVCALVL AALGLGTSGF LFVQGQNVLK
     NQELAFNQKI DKAALGESEN AALLKDNLNR QAAIQSELDR LDGNVKANGE QILEMQKSYR
     ELTKGRADWL VDETETILNL AAQQLVLTGN IQTAVGVLEH IDSRLSRFNQ AELLPIKQAV
     SSDLAELKNR PYVDISGTAL RLDRLETAVS GLPLMLDGVL KPGVQVKNEA ASASWWQNVW
     EKSLGTLKGL VEIRRLENND AMLISPEQAY FVRENLRLRL LDARTALMQR NSEVYQGDLN
     NAEAAVRQYF DAKSPATQSW LKELAELKAL DVRMTADDGL KNSLNAVRAY RDGTRMTAAE
     NQEAEQAASE PANEKTASEP AAASDVKTIE APSLPSERKP EQPAKKQTVP EKAGRSPSAK
     GERA
//