ID   Q9HTI5_PSEAE            Unreviewed;       458 AA.
AC   Q9HTI5;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   02-SEP-2026, entry version 114.
DE   RecName: Full=L-serine dehydratase {ECO:0000256|RuleBase:RU366059};
DE            EC=4.3.1.17 {ECO:0000256|RuleBase:RU366059};
GN   Name=sdaB {ECO:0000313|EMBL:AAG08764.1};
GN   OrderedLocusNames=PA5379 {ECO:0000313|EMBL:AAG08764.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pseudomonadales; Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG08764.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG08764.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = pyruvate + NH4(+); Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00049406,
CC         ECO:0000256|RuleBase:RU366059};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU366059};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000256|ARBA:ARBA00004742}.
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00008636, ECO:0000256|RuleBase:RU366059}.
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DR   EMBL; AE004091; AAG08764.1; -; Genomic_DNA.
DR   PIR; D82974; D82974.
DR   RefSeq; NP_254066.1; NC_002516.2.
DR   RefSeq; WP_003111339.1; NC_002516.2.
DR   AlphaFoldDB; Q9HTI5; -.
DR   SMR; Q9HTI5; -.
DR   FunCoup; Q9HTI5; 409.
DR   STRING; 208964.PA5379; -.
DR   PaxDb; 208964-PA5379; -.
DR   GeneID; 878445; -.
DR   KEGG; pae:PA5379; -.
DR   PATRIC; fig|208964.12.peg.5638; -.
DR   PseudoCAP; PA5379; -.
DR   HOGENOM; CLU_022305_0_1_6; -.
DR   InParanoid; Q9HTI5; -.
DR   OrthoDB; 9805537at2; -.
DR   PhylomeDB; Q9HTI5; -.
DR   BioCyc; PAER208964:G1FZ6-5506-MONOMER; -.
DR   Proteomes; UP000002438; Chromosome.
DR   AbasyAtlas; Q9HTI5; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031459; F:ABC-type glycine betaine transporter activity; IDA:PseudoCAP.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IBA:GO_Central.
DR   GO; GO:0009063; P:amino acid catabolic process; IEA:UniProtKB-ARBA.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR   FunFam; 3.30.1330.90:FF:000001; L-serine ammonia-lyase 1; 1.
DR   Gene3D; 3.30.1330.90; D-3-phosphoglycerate dehydrogenase, domain 3; 1.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR051318; Fe-S_L-Ser.
DR   InterPro; IPR004644; Fe-S_L-Ser_mono.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR005131; Ser_deHydtase_bsu.
DR   NCBIfam; TIGR00720; sda_mono; 1.
DR   PANTHER; PTHR30182; L-SERINE DEHYDRATASE; 1.
DR   PANTHER; PTHR30182:SF1; L-SERINE DEHYDRATASE 1; 1.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   Pfam; PF03315; SDH_beta; 1.
DR   SUPFAM; SSF143548; Serine metabolism enzymes domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU366059};
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU366059};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU366059};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU366059};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366059};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU366059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT   DOMAIN          4..155
FT                   /note="Serine dehydratase beta chain"
FT                   /evidence="ECO:0000259|Pfam:PF03315"
FT   DOMAIN          186..452
FT                   /note="Serine dehydratase-like alpha subunit"
FT                   /evidence="ECO:0000259|Pfam:PF03313"
SQ   SEQUENCE   458 AA;  49217 MW;  BF32CC554B302AA0 CRC64;
     MAISVFDLFK IGIGPSSSHT VGPMRAAALF TAALRQRQAL SAVRRLEVRL YGSLSATGVG
     HGTDRAVIMG LMGEWPDRID PTQIAPRMAA LLDSGLLQLD GRVAVPFDWV RDMRLLDENL
     PYHPNAMTLV AYGEQGELHQ ETYYSVGGGF VVDAAQAASG QLDQDHTVLP YDFSSAEELL
     LLCKRHNLRV SELMLANERI WRSETDIREG LRRIWQAMRD CVDNGLRNEG ILPGGLNVQR
     RAARLHRNLQ EIGKPNVIGS TLSAMEWVNL FALAVNEENA AGGRMVTAPT NGAAGIIPAV
     LHYYMKFNPD AQDRDVVDYL LAAAAVGILC KKNASISGAE VGCQGEVGSA CAMAAAGLAE
     VLGATPAQVE NAAEIGLEHN LGLTCDPVGG LVQVPCIERN AIAAVKAINA AQMALRGDGQ
     HFISLDKVIR TMRDTGADMH DKYKETSRGG LAVNAIEC
//