ID   Q9HJB6_THEAC            Unreviewed;       796 AA.
AC   Q9HJB6;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   04-NOV-2026, entry version 131.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   OrderedLocusNames=Ta1054 {ECO:0000313|EMBL:CAC12182.1};
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Methanobacteriati; Thermoplasmatota; Thermoplasmata;
OC   Thermoplasmatales; Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC12182.1, ECO:0000313|Proteomes:UP000001024};
RN   [1] {ECO:0000313|EMBL:CAC12182.1, ECO:0000313|Proteomes:UP000001024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC   {ECO:0000313|Proteomes:UP000001024};
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA   Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; AL445066; CAC12182.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HJB6; -.
DR   STRING; 273075.gene:9572274; -.
DR   PaxDb; 273075-gene:9572274; -.
DR   EnsemblBacteria; CAC12182; CAC12182; CAC12182.
DR   KEGG; tac:Ta1054; -.
DR   eggNOG; arCOG04367; Archaea.
DR   HOGENOM; CLU_002977_6_1_2; -.
DR   InParanoid; Q9HJB6; -.
DR   OMA; AACHIEN; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; IEA:TreeGrafter.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   FunFam; 3.90.199.10:FF:000001; DNA gyrase subunit A; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   InterPro; IPR050220; Type_II_DNA_Topoisomerases.
DR   NCBIfam; NF004043; gyrA; 1.
DR   NCBIfam; TIGR01063; gyrA; 1.
DR   NCBIfam; NF004044; PRK05561.1; 1.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR   PROSITE; PS52040; TOPO_IIA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001024};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          30..491
FT                   /note="Topo IIA-type catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS52040"
FT   COILED          428..469
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   796 AA;  89637 MW;  8541BC9C910761E0 CRC64;
     MHIMEKRAVE VEIRKSYLEY AMSVIVSRAI PDVRDGLKPV QRRVLYSMRE LGVTHDKPYK
     KCARIVGETM GKYHPHGDMA IYDALVRMAQ DFSLRYPLVD GQGNFGSIDG DSPAAMRYTE
     ARLTQIAEDM MDDIDENTVP FRLNFDGTLS EPEYLPSKIP NLLINGSSGI AVGMATNMVP
     HNLTEICDAI LYEVDHRDSP VDDLLKYVKG PDFPGGGIVF YGKDLIEAYR TGRGKVIVQG
     EVDATEDRRL IIKSIPYGVN KADLVQSIAD LAKNEVIKDI TDIKDESDRN GIRIVIKVRD
     DDIKPLVLNQ LYEHTALESS IGIINLVLVG NQPKLMNLKD LIDSFIDHRL DVILRRSQFR
     LDRKKERLDV LTGILTAVEH IDRVVEILKS SKDADEASSK LRNEFDLNDR QIKAILEMRL
     QRLVNTEQES VRSEIAQIQA EIKDLEEIIL SEDRRIDEFK KEITEIQKKY GDKRRSRIKF
     RGITERTMED LIPNEESLIM LSYGGLVKRV QADEYRSQRR GGKGVNTSMK TSDSIKSMIH
     CFSHDTVYYF TNTGRVFKSK AYEIPKKSRT SLGVSAAAFL KLAQGERVTE IMKAPPEKGY
     YLILVTRDGS VKKTAADPVF DSKSSGLKII TLEDDDELVS VSYTAGDKNM FVLSSKGKAS
     VFNTSEIRET GRTSMGVRSM RLNEGDTILT AFVVNSDEDI LSISEKGYGK RTNISEFPIH
     HRGSSGVMVY RDTERTGRVS HAIPVRDEDE VILVSMNEKT IRIKASEIPE TSRVTSGVKL
     MDIDGDDRVI AAAVIK
//