ID   Q9ESW2_RAT              Unreviewed;       212 AA.
AC   Q9ESW2; F1MAF9;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   04-NOV-2026, entry version 115.
DE   RecName: Full=Interleukin-1 alpha {ECO:0000256|ARBA:ARBA00017076};
GN   Name=Il1a {ECO:0000313|RGD:2890};
GN   Synonyms=IL-1 alpha {ECO:0000313|EMBL:CAC03996.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:CAC03996.1};
RN   [1] {ECO:0000313|EMBL:CAC03996.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Spraque Dawley {ECO:0000313|EMBL:CAC03996.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:CAC03996.1};
RA   Sultana T., Svechnikov K., Weber G., Soeder O.;
RT   "Production of recombinant rat testis interleukin-1 alpha precursor form
RT   and discovery of a novel splice version lacking the calpain cleavage
RT   site.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. Interacts with TMED10; the interaction mediates the
CC       translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-
CC       Golgi intermediate compartment) and thereby secretion. Interacts with
CC       IL1R1. Interacts with S100A13; this interaction is the first step in
CC       the export of IL1A, followed by direct translocation of this complex
CC       across the plasma membrane. {ECO:0000256|ARBA:ARBA00034134}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|ARBA:ARBA00010448}.
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DR   EMBL; AJ245643; CAC03996.1; -; mRNA.
DR   RefSeq; XP_038960173.1; XM_039104245.2.
DR   AlphaFoldDB; Q9ESW2; -.
DR   GeneID; 24493; -.
DR   CTD; 3552; -.
DR   RGD; 2890; Il1a.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProtKB-ARBA.
DR   CDD; cd23295; beta-trefoil_IL1A; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR003295; IL-1_alpha.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003502; IL-1_propep.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR10078:SF33; INTERLEUKIN-1 ALPHA; 1.
DR   PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01358; INTRLEUKIN1A.
DR   SMART; SM00125; IL1; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Pyrogen {ECO:0000256|ARBA:ARBA00022620};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          1..107
FT                   /note="Interleukin-1 propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF02394"
SQ   SEQUENCE   212 AA;  23990 MW;  81BA59003CBD295B CRC64;
     MAKVPDLFED LKNCYSENEE YSSAIDHLSL NQKSFYDASY GSLHENCTDK FVSLRTSETS
     KMSTFTFKES RVVVSATSNK GKILKKRRLS FNQPFTEDDL EAIAHDLEVK FDMYAYSSGG
     DDSKYPVTLK VSNTQLFVSA QGEDKPVLLK EIPETPKLIT GSETDLIFFW EKINSKNYFT
     SAAFPELLIA TKEQSQVHLA RGLPSMIDFQ IS
//