ID   Q9DF41_DANRE            Unreviewed;       291 AA.
AC   Q9DF41; Q6AXJ0;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   02-SEP-2026, entry version 171.
DE   SubName: Full=BHLH-WRPW transcription factor {ECO:0000313|EMBL:AAG23838.1};
DE   SubName: Full=Hairy-related 9 {ECO:0000313|EMBL:AAH79516.1};
GN   Name=her9 {ECO:0000313|EMBL:AAH79516.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-011213-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH79516.1};
RN   [1] {ECO:0000313|EMBL:AAG23838.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11702199; DOI=10.1007/s00427-001-0181-4;
RA   Leve C., Gajewski M., Rohr K.B., Tautz D.;
RT   "Homologues of c-hairy1 (her9) and lunatic fringe in zebrafish are
RT   expressed in the developing central nervous system, but not in the
RT   presomitic mesoderm.";
RL   Dev. Genes Evol. 211:493-500(2001).
RN   [2] {ECO:0000313|EMBL:AAH79516.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Singapore local strain {ECO:0000313|EMBL:AAH79516.1};
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH79516.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AF301264; AAG23838.1; -; mRNA.
DR   EMBL; BC079516; AAH79516.1; -; mRNA.
DR   RefSeq; NP_571948.1; NM_131873.1.
DR   AlphaFoldDB; Q9DF41; -.
DR   SMR; Q9DF41; -.
DR   STRING; 7955.ENSDARP00000073394; -.
DR   PaxDb; 7955-ENSDARP00000073394; -.
DR   GeneID; 140613; -.
DR   KEGG; dre:140613; -.
DR   AGR; ZFIN:ZDB-GENE-011213-1; -.
DR   CTD; 140613; -.
DR   ZFIN; ZDB-GENE-011213-1; her9.
DR   eggNOG; KOG4304; Eukaryota.
DR   GeneTree; ENSGT00940000163056; -.
DR   HOGENOM; CLU_068550_1_0_1; -.
DR   OMA; GPCKLNP; -.
DR   OrthoDB; 6085656at2759; -.
DR   Bgee; ENSDARG00000056438; Expressed in heart and 19 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0030282; P:bone mineralization; IMP:ZFIN.
DR   GO; GO:1904888; P:cranial skeletal system development; IGI:ZFIN.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IGI:ZFIN.
DR   GO; GO:0042462; P:eye photoreceptor cell development; IMP:ZFIN.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; IMP:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0097150; P:neuronal stem cell population maintenance; IMP:ZFIN.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; IMP:ZFIN.
DR   GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR   CDD; cd11459; bHLH-O_HES1_4; 1.
DR   FunFam; 4.10.280.10:FF:000009; Transcription factor HES-1; 1.
DR   Gene3D; 6.10.250.980; -; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR050370; HES_HEY.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00511; ORANGE; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF158457; Orange domain-like; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00981}; Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE-
KW   ProRule:PRU00981};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PROSITE-ProRule:PRU00981}.
FT   DOMAIN          34..91
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          110..143
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..91
FT                   /note="Helix-loop-helix motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00981"
FT   COMPBIAS        11..22
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  31002 MW;  817B630F296994A2 CRC64;
     MPADNMEKQT ASPIAGAPAS GSHTPDKPKN ASEHRKSSKP IMEKRRRARI NESLGQLKTL
     ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRVQMSAAL SADTNVLSKY RAGFNECMNE
     VTRFLSTCEG VNTEVRSRLL NHLSGCMGQM MAMNYPQPAP AQQAHLAQPL HVQLPSTLPI
     NGASMGSKLS PSEAVSPKVF GGFQLVPATD GQFAFLIPNP AFASATTPVI PLYANASVPV
     TVNASPVQAS SAPTVASPVQ GMTSFSGVPQ AVSPVGVSAG AESNEPVWRP W
//