ID RM15_MOUSE Reviewed; 295 AA. AC Q9CPR5; Q3UBN5; Q9CPP5; Q9CRH4; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 02-SEP-2026, entry version 157. DE RecName: Full=Large ribosomal subunit protein uL15m {ECO:0000305}; DE AltName: Full=39S ribosomal protein L15, mitochondrial; DE Short=L15mt; DE Short=MRP-L15; DE Flags: Precursor; GN Name=Mrpl15; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Embryo; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Kidney, and Liver; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S) CC which comprises a 16S rRNA and about 50 distinct proteins. CC {ECO:0000250|UniProtKB:Q9P015}. CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9P015}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9CPR5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9CPR5-2; Sequence=VSP_021370, VSP_021371; CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL15 family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB27054.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK003367; BAB22741.1; -; mRNA. DR EMBL; AK010474; BAB26967.1; -; mRNA. DR EMBL; AK010604; BAB27054.1; ALT_INIT; mRNA. DR EMBL; AK017804; BAB30943.1; -; mRNA. DR EMBL; AK017824; BAB30958.1; -; mRNA. DR EMBL; AK019175; BAB31589.1; -; mRNA. DR EMBL; AK019249; BAB31626.1; -; mRNA. DR EMBL; AK150880; BAE29929.1; -; mRNA. DR EMBL; AK160660; BAE35948.1; -; mRNA. DR EMBL; BC021304; AAH21304.1; -; mRNA. DR EMBL; BC027233; AAH27233.1; -; mRNA. DR CCDS; CCDS35504.1; -. [Q9CPR5-2] DR CCDS; CCDS48211.1; -. [Q9CPR5-1] DR RefSeq; NP_001171129.1; NM_001177658.2. [Q9CPR5-1] DR RefSeq; NP_079576.1; NM_025300.5. [Q9CPR5-2] DR PDB; 9E9C; EM; 3.62 A; M=1-295. DR PDB; 9HCC; EM; 5.67 A; M=1-295. DR PDB; 9HCD; EM; 4.63 A; M=1-295. DR PDB; 9HCE; EM; 7.31 A; M=1-295. DR PDB; 9HCF; EM; 2.85 A; M=1-295. DR PDB; 9HCG; EM; 2.91 A; M=9-295. DR PDB; 9HCH; EM; 2.85 A; M=1-295. DR AlphaFoldDB; Q9CPR5; -. DR EMDB; EMD-47791; -. DR EMDB; EMD-52044; -. DR EMDB; EMD-52045; -. DR EMDB; EMD-52046; -. DR EMDB; EMD-52047; -. DR EMDB; EMD-52048; -. DR EMDB; EMD-52049; -. DR SMR; Q9CPR5; -. DR BioGRID; 205202; 15. DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit. DR FunCoup; Q9CPR5; 2176. DR STRING; 10090.ENSMUSP00000115512; -. DR iPTMnet; Q9CPR5; -. DR PhosphoSitePlus; Q9CPR5; -. DR PaxDb; 10090-ENSMUSP00000115512; -. DR PeptideAtlas; Q9CPR5; -. DR ProteomicsDB; 260977; -. [Q9CPR5-1] DR ProteomicsDB; 260978; -. [Q9CPR5-2] DR Pumba; Q9CPR5; -. DR Antibodypedia; 24498; 184 antibodies from 26 providers. DR DNASU; 27395; -. DR Ensembl; ENSMUST00000130201.8; ENSMUSP00000114649.2; ENSMUSG00000033845.14. [Q9CPR5-2] DR Ensembl; ENSMUST00000156816.7; ENSMUSP00000115512.2; ENSMUSG00000033845.14. [Q9CPR5-1] DR GeneID; 27395; -. DR KEGG; mmu:27395; -. DR UCSC; uc007afd.3; mouse. [Q9CPR5-2] DR UCSC; uc007aff.3; mouse. [Q9CPR5-1] DR AGR; MGI:1351639; -. DR CTD; 29088; -. DR MGI; MGI:1351639; Mrpl15. DR VEuPathDB; HostDB:ENSMUSG00000033845; -. DR eggNOG; KOG0846; Eukaryota. DR GeneTree; ENSGT00390000009040; -. DR HOGENOM; CLU_055188_5_2_1; -. DR InParanoid; Q9CPR5; -. DR OMA; WFEGGQM; -. DR OrthoDB; 361383at2759; -. DR PhylomeDB; Q9CPR5; -. DR Reactome; R-MMU-5389840; Mitochondrial translation elongation. DR Reactome; R-MMU-5419276; Mitochondrial translation termination. DR Reactome; R-MMU-9937383; Mitochondrial ribosome-associated quality control. DR BioGRID-ORCS; 27395; 18 hits in 81 CRISPR screens. DR PRO; PR:Q9CPR5; -. DR Proteomes; UP000000589; Chromosome 1. DR RNAct; Q9CPR5; protein. DR Bgee; ENSMUSG00000033845; Expressed in blastoderm cell in morula and 252 other cell types or tissues. DR ExpressionAtlas; Q9CPR5; baseline and differential. DR GO; GO:0005743; C:mitochondrial inner membrane; NAS:ComplexPortal. DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB. DR GO; GO:0005739; C:mitochondrion; HDA:MGI. DR GO; GO:0003735; F:structural constituent of ribosome; ISA:MGI. DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI. DR GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal. DR GO; GO:0007005; P:mitochondrion organization; TAS:MGI. DR GO; GO:0006412; P:translation; ISA:MGI. DR FunFam; 3.100.10.10:FF:000006; 39S ribosomal protein L15, mitochondrial; 1. DR Gene3D; 3.100.10.10; -; 1. DR HAMAP; MF_01341; Ribosomal_uL15; 1. DR InterPro; IPR030878; Ribosomal_uL15. DR InterPro; IPR021131; Ribosomal_uL15/eL18. DR InterPro; IPR036227; Ribosomal_uL15/eL18_sf. DR InterPro; IPR005749; Ribosomal_uL15_bact. DR InterPro; IPR063184; Ribosomal_uL15_N. DR PANTHER; PTHR12934; 50S RIBOSOMAL PROTEIN L15; 1. DR PANTHER; PTHR12934:SF11; LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M; 1. DR Pfam; PF00828; Ribosomal_L27A; 1. DR Pfam; PF29471; Ribosomal_uL15_N; 1. DR SUPFAM; SSF52080; Ribosomal proteins L15p and L18e; 1. DR PDBsum; 9E9C; -. DR PDBsum; 9HCC; -. DR PDBsum; 9HCD; -. DR PDBsum; 9HCE; -. DR PDBsum; 9HCF; -. DR PDBsum; 9HCG; -. DR PDBsum; 9HCH; -. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Mitochondrion; Reference proteome; KW Ribonucleoprotein; Ribosomal protein; Transit peptide. FT TRANSIT 1..20 FT /note="Mitochondrion" FT /evidence="ECO:0000250|UniProtKB:Q0VC21" FT CHAIN 21..295 FT /note="Large ribosomal subunit protein uL15m" FT /id="PRO_0000257839" FT REGION 21..67 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 32..51 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 184..204 FT /note="EILCKPIPFFLRGQPIPKRML -> GHLMHSSDFHGFSARYSIHIK (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:16141072" FT /id="VSP_021370" FT VAR_SEQ 205..295 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:16141072" FT /id="VSP_021371" FT CONFLICT 1 FT /note="M -> L (in Ref. 1; BAB27054)" FT /evidence="ECO:0000305" FT CONFLICT 13 FT /note="D -> G (in Ref. 1; BAB27054)" FT /evidence="ECO:0000305" FT CONFLICT 36 FT /note="E -> G (in Ref. 1; BAB27054)" FT /evidence="ECO:0000305" FT CONFLICT 119 FT /note="Q -> K (in Ref. 1; BAE29929)" FT /evidence="ECO:0000305" FT HELIX 10..17 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 19..21 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 23..25 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 34..36 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 42..44 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 46..49 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 52..54 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 55..58 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 61..63 FT /evidence="ECO:0007829|PDB:9HCH" FT STRAND 68..70 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 73..75 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 84..88 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 91..96 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 97..105 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 111..113 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 117..122 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 130..132 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 134..140 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 144..146 FT /evidence="ECO:0007829|PDB:9HCH" FT STRAND 152..154 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 160..168 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 172..175 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 180..187 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 190..193 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 194..196 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 197..206 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 207..209 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 210..213 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 216..218 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 220..223 FT /evidence="ECO:0007829|PDB:9HCG" FT HELIX 225..227 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 228..238 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 242..244 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 246..249 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 252..256 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 264..267 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 273..275 FT /evidence="ECO:0007829|PDB:9HCF" FT TURN 276..279 FT /evidence="ECO:0007829|PDB:9HCF" FT STRAND 280..284 FT /evidence="ECO:0007829|PDB:9HCF" FT HELIX 287..294 FT /evidence="ECO:0007829|PDB:9HCF" SQ SEQUENCE 295 AA; 33542 MW; 2CAA781E82E4670C CRC64; MAGTARGCGT SLDLLRSLPR VSLANLKPSP NSRKRERRPR DRRRGRKCGR GHKGERQRGT RPRLGFEGGQ TPFYIRIPKY GFNEGHSFRH QYQPLSLRRL QYLIDLGRVD PTQPIDLTQL VNGRGVTIQP LKRDYGVQLV EEGADTFQAK INIEVQLASE LAIAAIEKNG GVVTTAFYDP RSLEILCKPI PFFLRGQPIP KRMLPPESLV PYYTDAKNRG YLADPAKFPE ARLELAMKFG YVLPDITKDE LFRMLSARKD PRQIFFGLAP GWVVNMADKK ILKPTDENLL KYYSS //