ID   CL042_HUMAN             Reviewed;         360 AA.
AC   Q96LP6; Q49A64; Q4G0S2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   04-NOV-2026, entry version 127.
DE   RecName: Full=Uncharacterized protein C12orf42;
GN   Name=C12orf42;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASP-11.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT
RP   ASP-11.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q96LP6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96LP6-2; Sequence=VSP_022691;
CC       Name=3;
CC         IsoId=Q96LP6-3; Sequence=VSP_022692, VSP_022693;
CC   -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC       premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC       decay. {ECO:0000305}.
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DR   EMBL; AK058052; BAB71641.1; -; mRNA.
DR   EMBL; AC084364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC126176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC039352; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC044617; AAH44617.1; -; mRNA.
DR   EMBL; BC117392; AAI17393.1; -; mRNA.
DR   EMBL; BC117394; AAI17395.1; -; mRNA.
DR   CCDS; CCDS44963.1; -. [Q96LP6-1]
DR   RefSeq; NP_001092806.1; NM_001099336.3. [Q96LP6-1]
DR   RefSeq; NP_001265348.1; NM_001278419.3. [Q96LP6-2]
DR   RefSeq; NP_001265349.1; NM_001278420.3. [Q96LP6-2]
DR   RefSeq; NP_001373800.1; NM_001386871.1. [Q96LP6-2]
DR   RefSeq; NP_940923.2; NM_198521.5. [Q96LP6-1]
DR   RefSeq; XP_011536594.1; XM_011538292.3. [Q96LP6-1]
DR   RefSeq; XP_011536595.1; XM_011538293.3. [Q96LP6-1]
DR   RefSeq; XP_016874765.1; XM_017019276.2. [Q96LP6-1]
DR   RefSeq; XP_047284759.1; XM_047428803.1. [Q96LP6-1]
DR   RefSeq; XP_054227954.1; XM_054371979.1. [Q96LP6-1]
DR   RefSeq; XP_054227955.1; XM_054371980.1. [Q96LP6-1]
DR   RefSeq; XP_054227956.1; XM_054371981.1. [Q96LP6-1]
DR   RefSeq; XP_054227957.1; XM_054371982.1. [Q96LP6-1]
DR   AlphaFoldDB; Q96LP6; -.
DR   BioGRID; 131906; 2.
DR   STRING; 9606.ENSP00000367353; -.
DR   iPTMnet; Q96LP6; -.
DR   PhosphoSitePlus; Q96LP6; -.
DR   BioMuta; C12orf42; -.
DR   jPOST; Q96LP6; -.
DR   MassIVE; Q96LP6; -.
DR   PaxDb; 9606-ENSP00000367353; -.
DR   PeptideAtlas; Q96LP6; -.
DR   Antibodypedia; 30495; 63 antibodies from 14 providers.
DR   DNASU; 374470; -.
DR   Ensembl; ENST00000378113.7; ENSP00000367353.2; ENSG00000179088.16. [Q96LP6-1]
DR   Ensembl; ENST00000547347.5; ENSP00000446908.1; ENSG00000179088.16. [Q96LP6-3]
DR   Ensembl; ENST00000548883.6; ENSP00000447908.1; ENSG00000179088.16. [Q96LP6-1]
DR   GeneID; 374470; -.
DR   KEGG; hsa:374470; -.
DR   MANE-Select; ENST00000548883.6; ENSP00000447908.1; NM_198521.5; NP_940923.2.
DR   UCSC; uc001tjt.4; human. [Q96LP6-1]
DR   AGR; HGNC:24729; -.
DR   ClinPGx; PA143485372; -.
DR   CTD; 374470; -.
DR   DisGeNET; 374470; -.
DR   GeneCards; C12orf42; -.
DR   HGNC; HGNC:24729; C12orf42.
DR   HPA; ENSG00000179088; Tissue enriched (testis).
DR   OpenTargets; ENSG00000179088; -.
DR   VEuPathDB; HostDB:ENSG00000179088; -.
DR   eggNOG; ENOG502RVJS; Eukaryota.
DR   GeneTree; ENSGT00390000015477; -.
DR   HOGENOM; CLU_2440222_0_0_1; -.
DR   InParanoid; Q96LP6; -.
DR   OrthoDB; 9836947at2759; -.
DR   PAN-GO; Q96LP6; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; Q96LP6; -.
DR   PathwayCommons; Q96LP6; -.
DR   Agora; ENSG00000179088; -.
DR   BioGRID-ORCS; 374470; 10 hits in 1110 CRISPR screens.
DR   ChiTaRS; C12orf42; human.
DR   GenomeRNAi; 374470; -.
DR   Pharos; Q96LP6; Tdark.
DR   PRO; PR:Q96LP6; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q96LP6; protein.
DR   Bgee; ENSG00000179088; Expressed in sperm and 105 other cell types or tissues.
DR   ExpressionAtlas; Q96LP6; baseline and differential.
DR   InterPro; IPR029288; DUF4607.
DR   PANTHER; PTHR40708; RIKEN CDNA 1700113H08 GENE; 1.
DR   PANTHER; PTHR40708:SF1; RIKEN CDNA 1700113H08 GENE; 1.
DR   Pfam; PF15380; DUF4607; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Proteomics identification; Reference proteome.
FT   CHAIN           1..360
FT                   /note="Uncharacterized protein C12orf42"
FT                   /id="PRO_0000274274"
FT   REGION          193..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..95
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022691"
FT   VAR_SEQ         87..107
FT                   /note="VFPERTQNSMACKRLLHTCQY -> GSHHGQATQKLQGAMVLHLEE (in
FT                   isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022692"
FT   VAR_SEQ         108..360
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022693"
FT   VARIANT         11
FT                   /note="E -> D (in dbSNP:rs10778257)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_030229"
FT   VARIANT         182
FT                   /note="P -> R (in dbSNP:rs7484376)"
FT                   /id="VAR_030230"
FT   CONFLICT        38
FT                   /note="A -> D (in Ref. 3; BC039352)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   360 AA;  39738 MW;  1935263A48633526 CRC64;
     MSTVICMKQR EEEFLLTIRP FANRMQKSPC YIPIVSSATL WDRSTPSAKH IPCYERTSVP
     CSRFINHMKN FSESPKFRSL HFLNFPVFPE RTQNSMACKR LLHTCQYIVP RCSVSTVSFD
     EESYEEFRSS PAPSSETDEA PLIFTARGET EERARGAPKQ AWNSSFLEQL VKKPNWAHSV
     NPVHLEAQGI HISRHTRPKG QPLSSPKKNS GSAARPSTAI GLCRRSQTPG ALQSTGPSNT
     ELEPEERMAV PAGAQAHPDD IQSRLLGASG NPVGKGAVAM APEMLPKHPH TPRDRRPQAD
     TSLHGNLAGA PLPLLAGAST HFPSKRLIKV CSSAPPRPTR RFHTVCSQAL SRPVVNAHLH
//