ID   SIM14_MOUSE             Reviewed;          99 AA.
AC   Q91VT8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   28-JAN-2026, entry version 144.
DE   RecName: Full=Small integral membrane protein 14;
GN   Name=Smim14;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD;
RC   TISSUE=Embryo, Eye, Retina, Testis, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=24499674; DOI=10.5483/bmbrep.2014.47.10.252;
RA   Jun M.H., Jun Y.W., Kim K.H., Lee J.A., Jang D.J.;
RT   "Characterization of the cellular localization of C4orf34 as a novel
RT   endoplasmic reticulum resident protein.";
RL   BMB Rep. 47:563-568(2014).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:24499674}.
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DR   EMBL; AK003345; BAC25031.1; -; mRNA.
DR   EMBL; AK018994; BAC25573.1; -; mRNA.
DR   EMBL; AK044669; BAC32025.1; -; mRNA.
DR   EMBL; AK088833; BAC40601.1; -; mRNA.
DR   EMBL; AK164394; BAE37770.1; -; mRNA.
DR   EMBL; BC009097; AAH09097.1; -; mRNA.
DR   CCDS; CCDS19309.1; -.
DR   RefSeq; NP_001363900.1; NM_001376971.1.
DR   RefSeq; NP_001363901.1; NM_001376972.1.
DR   RefSeq; NP_001363902.1; NM_001376973.1.
DR   RefSeq; NP_001363903.1; NM_001376974.1.
DR   RefSeq; NP_001363904.1; NM_001376975.1.
DR   RefSeq; NP_001363905.1; NM_001376976.1.
DR   RefSeq; NP_001363906.1; NM_001376977.1.
DR   RefSeq; NP_001363907.1; NM_001376978.1.
DR   RefSeq; NP_001363908.1; NM_001376979.1.
DR   RefSeq; NP_598458.1; NM_133697.4.
DR   RefSeq; XP_036021351.1; XM_036165458.1.
DR   AlphaFoldDB; Q91VT8; -.
DR   BioGRID; 212922; 1.
DR   FunCoup; Q91VT8; 1703.
DR   STRING; 10090.ENSMUSP00000122363; -.
DR   iPTMnet; Q91VT8; -.
DR   PhosphoSitePlus; Q91VT8; -.
DR   PaxDb; 10090-ENSMUSP00000122363; -.
DR   ProteomicsDB; 257178; -.
DR   Antibodypedia; 54789; 102 antibodies from 12 providers.
DR   Ensembl; ENSMUST00000121661.8; ENSMUSP00000113456.2; ENSMUSG00000037822.13.
DR   Ensembl; ENSMUST00000139122.8; ENSMUSP00000122363.2; ENSMUSG00000037822.13.
DR   GeneID; 68552; -.
DR   KEGG; mmu:68552; -.
DR   UCSC; uc008xnt.1; mouse.
DR   AGR; MGI:1915802; -.
DR   CTD; 201895; -.
DR   MGI; MGI:1915802; Smim14.
DR   VEuPathDB; HostDB:ENSMUSG00000037822; -.
DR   eggNOG; ENOG502S7T0; Eukaryota.
DR   GeneTree; ENSGT00390000018294; -.
DR   HOGENOM; CLU_152284_0_0_1; -.
DR   InParanoid; Q91VT8; -.
DR   OMA; ACTDTEC; -.
DR   OrthoDB; 10054061at2759; -.
DR   PhylomeDB; Q91VT8; -.
DR   BioGRID-ORCS; 68552; 1 hit in 76 CRISPR screens.
DR   PRO; PR:Q91VT8; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q91VT8; protein.
DR   Bgee; ENSMUSG00000037822; Expressed in parotid gland and 280 other cell types or tissues.
DR   ExpressionAtlas; Q91VT8; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001835; P:blastocyst hatching; IMP:MGI.
DR   InterPro; IPR020309; Smim-14.
DR   PANTHER; PTHR31019; SMALL INTEGRAL MEMBRANE PROTEIN 14; 1.
DR   PANTHER; PTHR31019:SF1; SMALL INTEGRAL MEMBRANE PROTEIN 14; 1.
DR   Pfam; PF11027; DUF2615; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..99
FT                   /note="Small integral membrane protein 14"
FT                   /id="PRO_0000268817"
FT   TOPO_DOM        1..49
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          77..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   99 AA;  10732 MW;  E953B9833FFF75AA CRC64;
     MAEGGFDPCE CVCSHEHAMR RLINLLRQSQ SYCTDTECLR ELPGPSSDSG ISITVILMAW
     MVIAMLLFLL RPPNLRGSSL PGKPSSPHSG QDPPAPPVD
//