ID   Q8ZRC3_SALTY            Unreviewed;       204 AA.
AC   Q8ZRC3;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   28-JAN-2026, entry version 131.
DE   RecName: Full=Cytochrome bo(3) ubiquinol oxidase subunit 3 {ECO:0000256|ARBA:ARBA00014687};
DE   AltName: Full=Cytochrome o ubiquinol oxidase subunit 3 {ECO:0000256|ARBA:ARBA00032189};
DE   AltName: Full=Oxidase bo(3) subunit 3 {ECO:0000256|ARBA:ARBA00030072};
DE   AltName: Full=Ubiquinol oxidase chain C {ECO:0000256|ARBA:ARBA00077247};
DE   AltName: Full=Ubiquinol oxidase polypeptide III {ECO:0000256|ARBA:ARBA00032717};
DE   AltName: Full=Ubiquinol oxidase subunit 3 {ECO:0000256|ARBA:ARBA00031884};
GN   Name=cyoC {ECO:0000313|EMBL:AAL19396.1};
GN   OrderedLocusNames=STM0441 {ECO:0000313|EMBL:AAL19396.1};
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL19396.1, ECO:0000313|Proteomes:UP000001014};
RN   [1] {ECO:0000313|EMBL:AAL19396.1, ECO:0000313|Proteomes:UP000001014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720
RC   {ECO:0000313|Proteomes:UP000001014};
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Cytochrome bo(3) ubiquinol terminal oxidase is the component
CC       of the aerobic respiratory chain of E.coli that predominates when cells
CC       are grown at high aeration. Has proton pump activity across the
CC       membrane in addition to electron transfer, pumping 2 protons/electron.
CC       {ECO:0000256|ARBA:ARBA00025694}.
CC   -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains and
CC       two D chains. {ECO:0000256|ARBA:ARBA00011700}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU003376}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU003376}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000256|ARBA:ARBA00010581, ECO:0000256|RuleBase:RU003376}.
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DR   EMBL; AE006468; AAL19396.1; -; Genomic_DNA.
DR   RefSeq; NP_459437.1; NC_003197.2.
DR   RefSeq; WP_000179833.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZRC3; -.
DR   SMR; Q8ZRC3; -.
DR   STRING; 99287.STM0441; -.
DR   PaxDb; 99287-STM0441; -.
DR   GeneID; 1251961; -.
DR   GeneID; 44979417; -.
DR   KEGG; stm:STM0441; -.
DR   PATRIC; fig|99287.12.peg.471; -.
DR   HOGENOM; CLU_044071_3_0_6; -.
DR   OMA; TFKAVNP; -.
DR   PhylomeDB; Q8ZRC3; -.
DR   BioCyc; SENT99287:STM0441-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0009319; C:cytochrome o ubiquinol oxidase complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IBA:GO_Central.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0019646; P:aerobic electron transport chain; IBA:GO_Central.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR   CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR   FunFam; 1.20.120.80:FF:000001; Cytochrome (Ubi)quinol oxidase subunit III; 1.
DR   Gene3D; 1.20.120.80; Cytochrome c oxidase, subunit III, four-helix bundle; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR   InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR   NCBIfam; TIGR02842; CyoC; 1.
DR   NCBIfam; NF007944; PRK10663.1; 1.
DR   PANTHER; PTHR11403:SF2; CYTOCHROME BO(3) UBIQUINOL OXIDASE SUBUNIT 3; 1.
DR   PANTHER; PTHR11403; CYTOCHROME C OXIDASE SUBUNIT III; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; Cytochrome c oxidase subunit III-like; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AAL19396.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001014};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003376};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..203
FT                   /note="Heme-copper oxidase subunit III family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50253"
SQ   SEQUENCE   204 AA;  22628 MW;  2842E32588F503B0 CRC64;
     MATDTLTHAT AHAHEHGHHD AGQNKIFGFW VYLMSDCILF SILFATYAVL VNGTAGGPTG
     KDIFELPFVL VETFLLLFSS ITYGMAAIAM HKNNKSQVIS WLALTFLFGA GFIGMELYEF
     HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQVARRGLT STNRTRIMCL
     SLFWHFLDVI WICVFTVVYL MGAM
//