ID   Q8TWS1_METKA            Unreviewed;       232 AA.
AC   Q8TWS1;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   02-SEP-2026, entry version 92.
DE   SubName: Full=Spermidine synthase {ECO:0000313|EMBL:AAM02174.1};
GN   Name=speE {ECO:0000313|EMBL:AAM02174.1};
GN   OrderedLocusNames=MK0961 {ECO:0000313|EMBL:AAM02174.1};
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Methanobacteriati; Methanobacteriota; Methanomada group;
OC   Methanopyri; Methanopyrales; Methanopyraceae; Methanopyrus.
OX   NCBI_TaxID=190192 {ECO:0000313|EMBL:AAM02174.1, ECO:0000313|Proteomes:UP000001826};
RN   [1] {ECO:0000313|EMBL:AAM02174.1, ECO:0000313|Proteomes:UP000001826}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938
RC   {ECO:0000313|Proteomes:UP000001826};
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
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DR   EMBL; AE009439; AAM02174.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TWS1; -.
DR   STRING; 190192.MK0961; -.
DR   PaxDb; 190192-MK0961; -.
DR   EnsemblBacteria; AAM02174; AAM02174; MK0961.
DR   KEGG; mka:MK0961; -.
DR   HOGENOM; CLU_1122661_0_0_2; -.
DR   InParanoid; Q8TWS1; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:TreeGrafter.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43317:SF3; BLR2883 PROTEIN; 1.
DR   PANTHER; PTHR43317; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR   Pfam; PF01564; Spermine_synth; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Polyamine biosynthesis {ECO:0000256|ARBA:ARBA00023115};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001826}.
SQ   SEQUENCE   232 AA;  26204 MW;  CBFBF727B1B07155 CRC64;
     MGVGEVVDNI GRGLLSEDRR AREAAARYRE WAESLDEEEL FRYVRERTGG LGHGKEGFEV
     GKMGLKGYVI AWPEQARGMV LEIGTGLGRT TWALLRWGDP ELIVSVEVDP RMLAIALYRN
     PVPEFSEALR DDRVKILLGD AVEVVPKLPR GFDHVVHDGG PCPGRNPRLF SPEFLRTIAE
     KLKDEGTASV FAGRDPRWQD RIYRALSRLF LEVRAESFPD TPTVVFRCEG RR
//