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<entry dataset="TrEMBL" created="2002-06-01" modified="2026-09-02" version="88" xmlns="http://uniprot.org/uniprot">
  <accession>Q8T9H4</accession>
  <name>Q8T9H4_DROME</name>
  <protein>
    <recommendedName>
      <fullName evidence="4">Peroxin-19</fullName>
    </recommendedName>
  </protein>
  <gene>
    <name evidence="7" type="primary">Pex19</name>
    <name evidence="6 7" type="ORF">CG5325</name>
  </gene>
  <organism evidence="6">
    <name type="scientific">Drosophila melanogaster</name>
    <name type="common">Fruit fly</name>
    <dbReference type="NCBI Taxonomy" id="7227"/>
    <lineage>
      <taxon>Eukaryota</taxon>
      <taxon>Metazoa</taxon>
      <taxon>Ecdysozoa</taxon>
      <taxon>Arthropoda</taxon>
      <taxon>Altocrustacea</taxon>
      <taxon>Allotriocarida</taxon>
      <taxon>Hexapoda</taxon>
      <taxon>Insecta</taxon>
      <taxon>Pterygota</taxon>
      <taxon>Neoptera</taxon>
      <taxon>Eumetabola</taxon>
      <taxon>Endopterygota</taxon>
      <taxon>Aparaglossata</taxon>
      <taxon>Panorpida</taxon>
      <taxon>Diptera</taxon>
      <taxon>Brachycera</taxon>
      <taxon>Muscomorpha</taxon>
      <taxon>Ephydroidea</taxon>
      <taxon>Drosophilidae</taxon>
      <taxon>Drosophila</taxon>
      <taxon>Sophophora</taxon>
    </lineage>
  </organism>
  <reference evidence="6" key="1">
    <citation type="submission" date="2001-12" db="EMBL/GenBank/DDBJ databases">
      <authorList>
        <person name="Stapleton M."/>
        <person name="Brokstein P."/>
        <person name="Hong L."/>
        <person name="Agbayani A."/>
        <person name="Carlson J."/>
        <person name="Champe M."/>
        <person name="Chavez C."/>
        <person name="Dorsett V."/>
        <person name="Farfan D."/>
        <person name="Frise E."/>
        <person name="George R."/>
        <person name="Gonzalez M."/>
        <person name="Guarin H."/>
        <person name="Li P."/>
        <person name="Liao G."/>
        <person name="Miranda A."/>
        <person name="Mungall C.J."/>
        <person name="Nunoo J."/>
        <person name="Pacleb J."/>
        <person name="Paragas V."/>
        <person name="Park S."/>
        <person name="Phouanenavong S."/>
        <person name="Wan K."/>
        <person name="Yu C."/>
        <person name="Lewis S.E."/>
        <person name="Rubin G.M."/>
        <person name="Celniker S."/>
      </authorList>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE</scope>
  </reference>
  <comment type="subcellular location">
    <subcellularLocation>
      <location evidence="1">Peroxisome</location>
    </subcellularLocation>
  </comment>
  <comment type="similarity">
    <text evidence="2">Belongs to the peroxin-19 family.</text>
  </comment>
  <dbReference type="EMBL" id="AY069294">
    <property type="protein sequence ID" value="AAL39439.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q8T9H4"/>
  <dbReference type="AGR" id="FB:FBgn0032407"/>
  <dbReference type="FlyBase" id="FBgn0032407">
    <property type="gene designation" value="Pex19"/>
  </dbReference>
  <dbReference type="VEuPathDB" id="VectorBase:FBgn0032407"/>
  <dbReference type="HOGENOM" id="CLU_043063_3_0_1"/>
  <dbReference type="OrthoDB" id="21292at2759"/>
  <dbReference type="PhylomeDB" id="Q8T9H4"/>
  <dbReference type="ExpressionAtlas" id="Q8T9H4">
    <property type="expression patterns" value="baseline and differential"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005777">
    <property type="term" value="C:peroxisome"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="FunFam" id="1.20.120.900:FF:000005">
    <property type="entry name" value="Blast:Peroxisomal biogenesis factor 19"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="1.20.120.900">
    <property type="entry name" value="Pex19, mPTS binding domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR006708">
    <property type="entry name" value="Pex19"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR038322">
    <property type="entry name" value="Pex19_C_sf"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR12774">
    <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR12774:SF2">
    <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF04614">
    <property type="entry name" value="Pex19"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="evidence at transcript level"/>
  <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
  <feature type="region of interest" description="Disordered" evidence="5">
    <location>
      <begin position="1"/>
      <end position="53"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="5">
    <location>
      <begin position="265"/>
      <end position="292"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
    <location>
      <begin position="21"/>
      <end position="32"/>
    </location>
  </feature>
  <evidence type="ECO:0000256" key="1">
    <source>
      <dbReference type="ARBA" id="ARBA00004275"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="2">
    <source>
      <dbReference type="ARBA" id="ARBA00006326"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="3">
    <source>
      <dbReference type="ARBA" id="ARBA00023140"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="4">
    <source>
      <dbReference type="ARBA" id="ARBA00029688"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="5">
    <source>
      <dbReference type="SAM" id="MobiDB-lite"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="6">
    <source>
      <dbReference type="EMBL" id="AAL39439.1"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="7">
    <source>
      <dbReference type="FlyBase" id="FBgn0032407"/>
    </source>
  </evidence>
  <sequence length="292" mass="31267" checksum="F328A1EB033C9A6E" modified="2002-06-01" version="1">MSEEKKNGDELNDLLDSALQDFDKSGAGDQKEPSASSDVATTAGAEGSEDPDAFFIEQAKVLADRMNTLFGGPDTPSGDIPPLPQDPDQIMAGFKKMAEAAALTLSGENSATDEDVSKYSDSISQALKGLQEGSENLAAPASENDIASMFGSLNLEGAGEGDGNMFLPFMEGMMQSLLSAEILLPSIRELLEKYPKYLEENDAKLSAEDKERYQKQMELYKVIEGHLQSEKTEDSAAVKREKFRVVLDDMRKLQDYGQPPPEILAETGGDLPFGDPTAGVAAGGPGPQCPTM</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>