<?xml version="1.0" encoding="UTF-8"  standalone="no" ?>
<uniprot xmlns="http://uniprot.org/uniprot" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2002-06-01" modified="2026-09-02" version="202" xmlns="http://uniprot.org/uniprot">
  <accession>Q8T9E6</accession>
  <accession>Q9VQ41</accession>
  <accession>Q9VQ42</accession>
  <name>Q8T9E6_DROME</name>
  <protein>
    <submittedName>
      <fullName evidence="12">SD03967p</fullName>
    </submittedName>
  </protein>
  <gene>
    <name evidence="12 13" type="ORF">CG17646</name>
  </gene>
  <organism evidence="12">
    <name type="scientific">Drosophila melanogaster</name>
    <name type="common">Fruit fly</name>
    <dbReference type="NCBI Taxonomy" id="7227"/>
    <lineage>
      <taxon>Eukaryota</taxon>
      <taxon>Metazoa</taxon>
      <taxon>Ecdysozoa</taxon>
      <taxon>Arthropoda</taxon>
      <taxon>Altocrustacea</taxon>
      <taxon>Allotriocarida</taxon>
      <taxon>Hexapoda</taxon>
      <taxon>Insecta</taxon>
      <taxon>Pterygota</taxon>
      <taxon>Neoptera</taxon>
      <taxon>Eumetabola</taxon>
      <taxon>Endopterygota</taxon>
      <taxon>Aparaglossata</taxon>
      <taxon>Panorpida</taxon>
      <taxon>Diptera</taxon>
      <taxon>Brachycera</taxon>
      <taxon>Muscomorpha</taxon>
      <taxon>Ephydroidea</taxon>
      <taxon>Drosophilidae</taxon>
      <taxon>Drosophila</taxon>
      <taxon>Sophophora</taxon>
    </lineage>
  </organism>
  <reference evidence="12" key="1">
    <citation type="submission" date="2001-12" db="EMBL/GenBank/DDBJ databases">
      <authorList>
        <person name="Stapleton M."/>
        <person name="Brokstein P."/>
        <person name="Hong L."/>
        <person name="Agbayani A."/>
        <person name="Carlson J."/>
        <person name="Champe M."/>
        <person name="Chavez C."/>
        <person name="Dorsett V."/>
        <person name="Farfan D."/>
        <person name="Frise E."/>
        <person name="George R."/>
        <person name="Gonzalez M."/>
        <person name="Guarin H."/>
        <person name="Li P."/>
        <person name="Liao G."/>
        <person name="Miranda A."/>
        <person name="Mungall C.J."/>
        <person name="Nunoo J."/>
        <person name="Pacleb J."/>
        <person name="Paragas V."/>
        <person name="Park S."/>
        <person name="Phouanenavong S."/>
        <person name="Wan K."/>
        <person name="Yu C."/>
        <person name="Lewis S.E."/>
        <person name="Rubin G.M."/>
        <person name="Celniker S."/>
      </authorList>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE</scope>
  </reference>
  <comment type="subcellular location">
    <subcellularLocation>
      <location evidence="1">Membrane</location>
      <topology evidence="1">Multi-pass membrane protein</topology>
    </subcellularLocation>
  </comment>
  <comment type="similarity">
    <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
  </comment>
  <dbReference type="EMBL" id="AY069801">
    <property type="protein sequence ID" value="AAL39946.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="NP_608618.1">
    <property type="nucleotide sequence ID" value="NM_134774.3"/>
  </dbReference>
  <dbReference type="RefSeq" id="NP_722727.1">
    <property type="nucleotide sequence ID" value="NM_164436.2"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q8T9E6"/>
  <dbReference type="SMR" id="Q8T9E6"/>
  <dbReference type="STRING" id="7227.FBpp0077554"/>
  <dbReference type="PaxDb" id="7227-FBpp0077554"/>
  <dbReference type="PeptideAtlas" id="Q8T9E6"/>
  <dbReference type="GeneID" id="33354"/>
  <dbReference type="KEGG" id="dme:Dmel_CG17646"/>
  <dbReference type="UCSC" id="CG17646-RA">
    <property type="organism name" value="d. melanogaster"/>
  </dbReference>
  <dbReference type="AGR" id="FB:FBgn0264494"/>
  <dbReference type="FlyBase" id="FBgn0264494">
    <property type="gene designation" value="CG17646"/>
  </dbReference>
  <dbReference type="VEuPathDB" id="VectorBase:FBgn0264494"/>
  <dbReference type="eggNOG" id="KOG0061">
    <property type="taxonomic scope" value="Eukaryota"/>
  </dbReference>
  <dbReference type="HOGENOM" id="CLU_000604_57_6_1"/>
  <dbReference type="OMA" id="DRYRYMS"/>
  <dbReference type="OrthoDB" id="66620at2759"/>
  <dbReference type="Reactome" id="R-DME-1369062">
    <property type="pathway name" value="ABC transporters in lipid homeostasis"/>
  </dbReference>
  <dbReference type="Reactome" id="R-DME-8964058">
    <property type="pathway name" value="HDL remodeling"/>
  </dbReference>
  <dbReference type="BioGRID-ORCS" id="33354">
    <property type="hits" value="0 hits in 1 CRISPR screen"/>
  </dbReference>
  <dbReference type="Bgee" id="FBgn0264494">
    <property type="expression patterns" value="Expressed in fat body cell in Malpighian tubule and 223 other cell types or tissues"/>
  </dbReference>
  <dbReference type="GO" id="GO:0016020">
    <property type="term" value="C:membrane"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-SubCell"/>
  </dbReference>
  <dbReference type="GO" id="GO:0140359">
    <property type="term" value="F:ABC-type transporter activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005524">
    <property type="term" value="F:ATP binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0016887">
    <property type="term" value="F:ATP hydrolysis activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0006641">
    <property type="term" value="P:triglyceride metabolic process"/>
    <property type="evidence" value="ECO:0000315"/>
    <property type="project" value="FlyBase"/>
  </dbReference>
  <dbReference type="CDD" id="cd03213">
    <property type="entry name" value="ABCG_EPDR"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.40.50.300:FF:001077">
    <property type="entry name" value="Uncharacterized protein, isoform A"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.40.50.300">
    <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR003593">
    <property type="entry name" value="AAA+_ATPase"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR013525">
    <property type="entry name" value="ABC2_TM"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR003439">
    <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR017871">
    <property type="entry name" value="ABC_transporter-like_CS"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR043926">
    <property type="entry name" value="ABCG_dom"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR050352">
    <property type="entry name" value="ABCG_transporters"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR027417">
    <property type="entry name" value="P-loop_NTPase"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR48041">
    <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR48041:SF61">
    <property type="entry name" value="SD03967P"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF01061">
    <property type="entry name" value="ABC2_membrane"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF19055">
    <property type="entry name" value="ABC2_membrane_7"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF00005">
    <property type="entry name" value="ABC_tran"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SMART" id="SM00382">
    <property type="entry name" value="AAA"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF52540">
    <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS00211">
    <property type="entry name" value="ABC_TRANSPORTER_1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS50893">
    <property type="entry name" value="ABC_TRANSPORTER_2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="evidence at transcript level"/>
  <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
  <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
  <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
  <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
  <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
  <keyword evidence="3" id="KW-0813">Transport</keyword>
  <feature type="transmembrane region" description="Helical" evidence="10">
    <location>
      <begin position="510"/>
      <end position="531"/>
    </location>
  </feature>
  <feature type="transmembrane region" description="Helical" evidence="10">
    <location>
      <begin position="543"/>
      <end position="566"/>
    </location>
  </feature>
  <feature type="transmembrane region" description="Helical" evidence="10">
    <location>
      <begin position="587"/>
      <end position="609"/>
    </location>
  </feature>
  <feature type="transmembrane region" description="Helical" evidence="10">
    <location>
      <begin position="624"/>
      <end position="646"/>
    </location>
  </feature>
  <feature type="transmembrane region" description="Helical" evidence="10">
    <location>
      <begin position="653"/>
      <end position="675"/>
    </location>
  </feature>
  <feature type="transmembrane region" description="Helical" evidence="10">
    <location>
      <begin position="741"/>
      <end position="760"/>
    </location>
  </feature>
  <feature type="domain" description="ABC transporter" evidence="11">
    <location>
      <begin position="106"/>
      <end position="351"/>
    </location>
  </feature>
  <feature type="binding site" evidence="9">
    <location>
      <begin position="148"/>
      <end position="155"/>
    </location>
    <ligand>
      <name>ATP</name>
      <dbReference type="ChEBI" id="CHEBI:30616"/>
    </ligand>
  </feature>
  <evidence type="ECO:0000256" key="1">
    <source>
      <dbReference type="ARBA" id="ARBA00004141"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="2">
    <source>
      <dbReference type="ARBA" id="ARBA00005814"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="3">
    <source>
      <dbReference type="ARBA" id="ARBA00022448"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="4">
    <source>
      <dbReference type="ARBA" id="ARBA00022692"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="5">
    <source>
      <dbReference type="ARBA" id="ARBA00022741"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="6">
    <source>
      <dbReference type="ARBA" id="ARBA00022840"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="7">
    <source>
      <dbReference type="ARBA" id="ARBA00022989"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="8">
    <source>
      <dbReference type="ARBA" id="ARBA00023136"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="9">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00434"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="10">
    <source>
      <dbReference type="SAM" id="Phobius"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="11">
    <source>
      <dbReference type="PROSITE" id="PS50893"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="12">
    <source>
      <dbReference type="EMBL" id="AAL39946.1"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="13">
    <source>
      <dbReference type="FlyBase" id="FBgn0264494"/>
    </source>
  </evidence>
  <sequence length="766" mass="84998" checksum="1826E89CE7F5F5EB" modified="2002-06-01" version="1">MTLLPDIKASDAACCVGGANSDASSSSGVCSLKGHHGDPDSGCLGINCCTTAASSELSIDETSSTSSRGSCELTSKVTNDLNGFQSPNYHQAVAHANFDHCDPVDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCSTGVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDHRYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYFMLLGIMASLSAQAWGFFVGATLPTKLAVFLGPILAVMFSVFGFCTRYIDITPLFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVLTLITLWHKLNKR</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>