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<entry dataset="TrEMBL" created="2002-06-01" modified="2026-09-02" version="118" xmlns="http://uniprot.org/uniprot">
  <accession>Q8T9C8</accession>
  <name>Q8T9C8_DROME</name>
  <protein>
    <submittedName>
      <fullName evidence="12">SD07276p</fullName>
    </submittedName>
  </protein>
  <gene>
    <name evidence="13" type="primary">Zmynd8</name>
    <name evidence="12 13" type="ORF">CG1815</name>
  </gene>
  <organism evidence="12">
    <name type="scientific">Drosophila melanogaster</name>
    <name type="common">Fruit fly</name>
    <dbReference type="NCBI Taxonomy" id="7227"/>
    <lineage>
      <taxon>Eukaryota</taxon>
      <taxon>Metazoa</taxon>
      <taxon>Ecdysozoa</taxon>
      <taxon>Arthropoda</taxon>
      <taxon>Altocrustacea</taxon>
      <taxon>Allotriocarida</taxon>
      <taxon>Hexapoda</taxon>
      <taxon>Insecta</taxon>
      <taxon>Pterygota</taxon>
      <taxon>Neoptera</taxon>
      <taxon>Eumetabola</taxon>
      <taxon>Endopterygota</taxon>
      <taxon>Aparaglossata</taxon>
      <taxon>Panorpida</taxon>
      <taxon>Diptera</taxon>
      <taxon>Brachycera</taxon>
      <taxon>Muscomorpha</taxon>
      <taxon>Ephydroidea</taxon>
      <taxon>Drosophilidae</taxon>
      <taxon>Drosophila</taxon>
      <taxon>Sophophora</taxon>
    </lineage>
  </organism>
  <reference evidence="12" key="1">
    <citation type="submission" date="2001-12" db="EMBL/GenBank/DDBJ databases">
      <authorList>
        <person name="Stapleton M."/>
        <person name="Brokstein P."/>
        <person name="Hong L."/>
        <person name="Agbayani A."/>
        <person name="Carlson J."/>
        <person name="Champe M."/>
        <person name="Chavez C."/>
        <person name="Dorsett V."/>
        <person name="Farfan D."/>
        <person name="Frise E."/>
        <person name="George R."/>
        <person name="Gonzalez M."/>
        <person name="Guarin H."/>
        <person name="Li P."/>
        <person name="Liao G."/>
        <person name="Miranda A."/>
        <person name="Mungall C.J."/>
        <person name="Nunoo J."/>
        <person name="Pacleb J."/>
        <person name="Paragas V."/>
        <person name="Park S."/>
        <person name="Phouanenavong S."/>
        <person name="Wan K."/>
        <person name="Yu C."/>
        <person name="Lewis S.E."/>
        <person name="Rubin G.M."/>
        <person name="Celniker S."/>
      </authorList>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE</scope>
  </reference>
  <dbReference type="EMBL" id="AY069824">
    <property type="protein sequence ID" value="AAL39969.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q8T9C8"/>
  <dbReference type="AGR" id="FB:FBgn0039863"/>
  <dbReference type="FlyBase" id="FBgn0039863">
    <property type="gene designation" value="Zmynd8"/>
  </dbReference>
  <dbReference type="VEuPathDB" id="VectorBase:FBgn0039863"/>
  <dbReference type="OrthoDB" id="298344at2759"/>
  <dbReference type="ExpressionAtlas" id="Q8T9C8">
    <property type="expression patterns" value="baseline and differential"/>
  </dbReference>
  <dbReference type="CDD" id="cd15538">
    <property type="entry name" value="PHD_PRKCBP1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="CDD" id="cd20160">
    <property type="entry name" value="PWWP_PRKCBP1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="2.30.30.140">
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="1.20.920.10">
    <property type="entry name" value="Bromodomain-like"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.30.40.10">
    <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR001487">
    <property type="entry name" value="Bromodomain"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR036427">
    <property type="entry name" value="Bromodomain-like_sf"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR044075">
    <property type="entry name" value="PRKCBP1_PHD"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR000313">
    <property type="entry name" value="PWWP_dom"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR019786">
    <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR011011">
    <property type="entry name" value="Znf_FYVE_PHD"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR001965">
    <property type="entry name" value="Znf_PHD"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR019787">
    <property type="entry name" value="Znf_PHD-finger"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR013083">
    <property type="entry name" value="Znf_RING/FYVE/PHD"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR46453">
    <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN 1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR46453:SF5">
    <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN 1 ISOFORM X1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF00855">
    <property type="entry name" value="PWWP"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SMART" id="SM00249">
    <property type="entry name" value="PHD"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SMART" id="SM00293">
    <property type="entry name" value="PWWP"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF47370">
    <property type="entry name" value="Bromodomain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF57903">
    <property type="entry name" value="FYVE/PHD zinc finger"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF63748">
    <property type="entry name" value="Tudor/PWWP/MBT"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS50014">
    <property type="entry name" value="BROMODOMAIN_2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS50812">
    <property type="entry name" value="PWWP"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS01359">
    <property type="entry name" value="ZF_PHD_1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS50016">
    <property type="entry name" value="ZF_PHD_2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="evidence at transcript level"/>
  <keyword evidence="4 6" id="KW-0103">Bromodomain</keyword>
  <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
  <keyword evidence="5" id="KW-0539">Nucleus</keyword>
  <keyword evidence="3" id="KW-0862">Zinc</keyword>
  <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
  <feature type="domain" description="PHD-type" evidence="10">
    <location>
      <begin position="129"/>
      <end position="175"/>
    </location>
  </feature>
  <feature type="domain" description="Bromo" evidence="9">
    <location>
      <begin position="223"/>
      <end position="273"/>
    </location>
  </feature>
  <feature type="domain" description="PWWP" evidence="11">
    <location>
      <begin position="314"/>
      <end position="365"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="37"/>
      <end position="56"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="81"/>
      <end position="107"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="458"/>
      <end position="479"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="533"/>
      <end position="601"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="643"/>
      <end position="691"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="705"/>
      <end position="759"/>
    </location>
  </feature>
  <feature type="region of interest" description="Disordered" evidence="8">
    <location>
      <begin position="790"/>
      <end position="812"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
    <location>
      <begin position="44"/>
      <end position="56"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Polar residues" evidence="8">
    <location>
      <begin position="82"/>
      <end position="94"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Low complexity" evidence="8">
    <location>
      <begin position="95"/>
      <end position="106"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Polar residues" evidence="8">
    <location>
      <begin position="462"/>
      <end position="476"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Basic residues" evidence="8">
    <location>
      <begin position="561"/>
      <end position="570"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
    <location>
      <begin position="571"/>
      <end position="586"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Pro residues" evidence="8">
    <location>
      <begin position="660"/>
      <end position="670"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Polar residues" evidence="8">
    <location>
      <begin position="721"/>
      <end position="738"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Low complexity" evidence="8">
    <location>
      <begin position="739"/>
      <end position="748"/>
    </location>
  </feature>
  <feature type="compositionally biased region" description="Pro residues" evidence="8">
    <location>
      <begin position="792"/>
      <end position="805"/>
    </location>
  </feature>
  <evidence type="ECO:0000256" key="1">
    <source>
      <dbReference type="ARBA" id="ARBA00022723"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="2">
    <source>
      <dbReference type="ARBA" id="ARBA00022771"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="3">
    <source>
      <dbReference type="ARBA" id="ARBA00022833"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="4">
    <source>
      <dbReference type="ARBA" id="ARBA00023117"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="5">
    <source>
      <dbReference type="ARBA" id="ARBA00023242"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="6">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00035"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="7">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00146"/>
    </source>
  </evidence>
  <evidence type="ECO:0000256" key="8">
    <source>
      <dbReference type="SAM" id="MobiDB-lite"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="9">
    <source>
      <dbReference type="PROSITE" id="PS50014"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="10">
    <source>
      <dbReference type="PROSITE" id="PS50016"/>
    </source>
  </evidence>
  <evidence type="ECO:0000259" key="11">
    <source>
      <dbReference type="PROSITE" id="PS50812"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="12">
    <source>
      <dbReference type="EMBL" id="AAL39969.1"/>
    </source>
  </evidence>
  <evidence type="ECO:0000313" key="13">
    <source>
      <dbReference type="FlyBase" id="FBgn0039863"/>
    </source>
  </evidence>
  <sequence length="907" mass="102212" checksum="A952955A2D5ECB20" modified="2002-06-01" version="1">MAFEDGERLANLNAEDRNIVPAYSMATRCRSRSKTLSLSNSWSNDDKGPRRSNLRSENEEFAKKHNAFLDRIIHDDRESELALNTSGEGESSLFSDASDTKTTTAKTPEEEAAERLALIYEEPPTPGWDPFCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSSWKCPECQVIEAAPKRLRRNGVSVDLLSQLLSFALDRMKHVRGAHKLRSPLEVFPLTYKKFFVNPVSFESLAQCIRNGAYQSTDEFLSEVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPECYLNANSSDEWFVKVCRHPHLLLWAKLKGFPYWPAKAMGSSNSTLVNVRFFGKHDRAFVPVKDCFLYSAQNPNTQTSRRSARDLAECIREVEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQLEQMMPGVYAAIDRELEPANKTPLQFLIRKTADDKLSIVKKTKATESGNESDQSPSPTKKLSEVDVVSVTGSGCSDHSNVKSNNYEVISRSGESLTDSRCKVLLKRKSLAAKIVAESVETSEAVAPKRKHSLSDASFTSESSEHKRKSKHARKQHDNQDNQIEEAEKTGQEPPKSPTISKQNENLRDEENVIENAANDTSSASPVSASVVSVVELVRRRQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQNIPKGNEAANPKQSDVERQQEQLIKKVIPFIEIKTEVMSEPDDEGIEEASPANQPQTDQVPLQQETITAQPESQMPAAAPAPQPKPVDNAPFEEVRIKEEILSEDEMETEQSIVSRRLKSVPPMPLPMPPPPPLPPREESPATADSVRFVGDTTIQRVYHRHPLQLTRPFCQPHLHLRHHQSQLARLLLASHRLRHRPRESLRHTFNFEEKTIVSQPPHRRLLHQPQTRLLCSDPTW</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>