Q9VAM5 Q2XY62 Q8T9B8 BRD8_DROME Bromodomain-containing protein 8 Brd8 CG14514 Drosophila melanogaster Fruit fly Eukaryota Metazoa Ecdysozoa Arthropoda Altocrustacea Allotriocarida Hexapoda Insecta Pterygota Neoptera Eumetabola Endopterygota Aparaglossata Panorpida Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora The genome sequence of Drosophila melanogaster. NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] Berkeley Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. GENOME REANNOTATION Berkeley A Drosophila full-length cDNA resource. NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] Berkeley Embryo Intragenic Hill-Robertson interference influences selection intensity on synonymous mutations in Drosophila. NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-866 Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. FUNCTION IDENTIFICATION IN THE TIP60 COMPLEX Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms. FUNCTION IDENTIFICATION IN THE NUA4 COMPLEX AND A SWR1-LIKE COMPLEX SUBCELLULAR LOCATION Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408). Component of the NuA4 histone acetyltransferase complex at least composed of Domino, Brd8, MRG15, YL-1, MrgBP, pont, rept, DMAP1, Tip60, Ing3, Nipped-A, E(Pc), Gas41 and Bap55 (PubMed:32432549). Component of a SWR1-like complex at least composed of Domino, Brd8, MrgBP, YL-1, Gas41, Bap55, Arp6, DMAP1, MRG15, pont, rept and Hcf (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex which contains Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, pont, rept, Ing3, Act87E, Bap55, MRG15, MrgBP, Gas41 and YL-1 (PubMed:15528408). Nucleus Chromosome Truncated N-terminus. Truncated C-terminus. Bromodomain Chromatin regulator Chromosome Nucleus Reference proteome Transcription Transcription regulation Q H A ALA M K ANES VNEG A D P S A T S A A T MSAGVQERLQLSRMPLDTWSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLAVKRSNQAADTTSVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQDCQAIKEFSQLPDVQAGITATPVSNTGSLRADKSSGSKARSGSRKSQRHH Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License