ID   Q8PS13_METMA            Unreviewed;       436 AA.
AC   Q8PS13;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   04-NOV-2026, entry version 139.
DE   SubName: Full=Conserved protein {ECO:0000313|EMBL:AAM32971.1};
GN   OrderedLocusNames=MM_3275 {ECO:0000313|EMBL:AAM32971.1};
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952 {ECO:0000313|EMBL:AAM32971.1, ECO:0000313|Proteomes:UP000000595};
RN   [1] {ECO:0000313|EMBL:AAM32971.1, ECO:0000313|Proteomes:UP000000595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88
RC   {ECO:0000313|Proteomes:UP000000595};
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baumer S., Jacobi C.,
RA   Bruggemann H., Lienard T., Christmann A., Bomeke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.P., Gunsalus R.P.,
RA   Fritz H.J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AE008384; AAM32971.1; -; Genomic_DNA.
DR   RefSeq; WP_011035164.1; NC_003901.1.
DR   DNASU; 1481617; -.
DR   GeneID; 24878090; -.
DR   KEGG; mma:MM_3275; -.
DR   PATRIC; fig|192952.21.peg.3805; -.
DR   eggNOG; arCOG00626; Archaea.
DR   HOGENOM; CLU_015237_4_0_2; -.
DR   OMA; AADHFQW; -.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   InterPro; IPR051676; UPF0053_domain.
DR   PANTHER; PTHR43099:SF5; HLYC_CORC FAMILY TRANSPORTER; 1.
DR   PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01595; CNNM; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   Proteomes; UP000000595; Chromosome.
DR   AlphaFoldDB; Q8PS13; -.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW   ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..200
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          219..280
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          283..340
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   436 AA;  47930 MW;  835688C872681E02 CRC64;
     MPYLPEVIII LVLIALNGIF AMSEFALVSA KKIRLRQKAE KGDAGAETAL KLSNEPTAFL
     STVQIGITLV GIFAGAFGGA TIAGELDTYL RDFPALARYS ATLSITLVVL IITYLTLILG
     ELVPKQLALN NAETIASRVA KPMFFLSLMA RPLVLVLSYS TDAVLRLLRV RKIIGPPVTE
     EEIKIMIEEG TEAGVFERAE MSMIEGVFDI GDRRVESLMT HRSDIIALDL DDPVDENLKK
     MIASGRSNFP VYERDLDDVI GIVSVKDVLA KLVESGKVDI RASVTKPLFA PEAITILKLL
     ESFKETGMHI ALITDEYGSV QGIITLHDIL EAIVGDVRSL GEPEEEQITV LENGSWLIDG
     DTPVNKLKYV LSVDSFPGEE QGYYLTIAGL IMYILQRIPK TGDHMEFNGL RYEVVDMDGI
     RIDKVMVTKV PEISKD
//