ID   Q8MRC3_DROME            Unreviewed;       563 AA.
AC   Q8MRC3;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   02-SEP-2026, entry version 91.
DE   RecName: Full=Splicing factor Cactin {ECO:0000256|ARBA:ARBA00034534};
GN   Name=cactin {ECO:0000313|EMBL:AAM51997.1,
GN   ECO:0000313|FlyBase:FBgn0031114};
GN   ORFNames=CG1676 {ECO:0000313|FlyBase:FBgn0031114};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM51997.1};
RN   [1] {ECO:0000313|EMBL:AAM51997.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAM51997.1};
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA   Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA   Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA   Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the CACTIN family.
CC       {ECO:0000256|ARBA:ARBA00006895}.
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DR   EMBL; AY121670; AAM51997.1; -; mRNA.
DR   AlphaFoldDB; Q8MRC3; -.
DR   AGR; FB:FBgn0031114; -.
DR   FlyBase; FBgn0031114; cactin.
DR   VEuPathDB; VectorBase:FBgn0031114; -.
DR   HOGENOM; CLU_011759_0_0_1; -.
DR   OrthoDB; 265955at2759; -.
DR   Bgee; FBgn0031114; Expressed in eye disc (Drosophila) and 53 other cell types or tissues.
DR   ExpressionAtlas; Q8MRC3; baseline and differential.
DR   InterPro; IPR019134; Cactin_C.
DR   InterPro; IPR018816; Cactin_central.
DR   PANTHER; PTHR21737; POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3; 1.
DR   PANTHER; PTHR21737:SF4; SPLICING FACTOR CACTIN; 1.
DR   Pfam; PF10312; Cactin_mid; 1.
DR   Pfam; PF09732; CactinC_cactus; 1.
DR   SMART; SM01050; CactinC_cactus; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          86..277
FT                   /note="Splicing factor cactin central"
FT                   /evidence="ECO:0000259|Pfam:PF10312"
FT   DOMAIN          440..563
FT                   /note="Splicing factor Cactin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09732"
FT   REGION          292..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          50..78
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        308..332
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..382
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  67271 MW;  FBC382C2FB27FDD0 CRC64;
     MGWDNEYQTY SNEDNPFGDS NLTSTFHWGK KLEVEGLSNL STKTVEVLSL QKQLENRREL
     EKVKKRRQER ELERQVREDD LMMQQRAKEA VQFREWQRQE DQFHLEQARL RSEIRIRDGR
     AKPIDLLAQY VAAGNEPLEE CLEMQMHEPY VLLNGLPVEE LEDLLVDIKV YEELEQGKHI
     DFWNDMITIV QDELQRQQKL EAENSSLNQR RDGIHQAVVK DVADIFRGKN AQQLEEMRHR
     IEAKISGRAD GVDISYWESL LSQLKAHMAR ARLRDRHQAL LREKLSLLKR ENDNETLQEK
     VAPQVKEEEM ETQDAEDPEV EEGSPEDEED PLNELRKTVR LYQAGNYSPR YIREEDFTGR
     RAQNEDVDEP EAEGLLYEEE DDERRTQRQR LLILHPERVD NNQLTPQELR MRNEAKQGMQ
     GDEAEFSVET TLDAVPQLAT DKYRPRKPRY FNRVHTGFEW NKYNQTHYDM DNPPPKIVQG
     YKFNIFYPDL MDKSQTPQYF LTPCADNGDF AVLRFHTGPP YEDIAFKIVN REWEFSYKRG
     FRCQFHNNIF QLWFRFKRYR YRR
//