ID   Q8MJD2_RABIT            Unreviewed;       198 AA.
AC   Q8MJD2;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   29-MAY-2024, entry version 51.
DE   SubName: Full=Tyrosine hydroxylase {ECO:0000313|EMBL:AAM46840.1};
DE   Flags: Fragment;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|EMBL:AAM46840.1};
RN   [1] {ECO:0000313|EMBL:AAM46840.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12122138; DOI=10.1113/jphysiol.2002.018382;
RA   Sanchez D., Lopez-Lopez J.R., Perez-Garcia M.T., Sanz-Alfayate G.,
RA   Obeso A., Ganfornina M.D., Gonzalez C.;
RT   "Molecular identification of Kv alpha subunits that contribute to the
RT   oxygen-sensitive K(+) current of chemoreceptor cells of the rabbit carotid
RT   body.";
RL   J. Physiol. (Lond.) 542:369-382(2002).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR   EMBL; AF493546; AAM46840.1; -; mRNA.
DR   AlphaFoldDB; Q8MJD2; -.
DR   GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:TreeGrafter.
DR   GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR   GO; GO:0007507; P:heart development; IEA:TreeGrafter.
DR   GO; GO:0045471; P:response to ethanol; IEA:TreeGrafter.
DR   GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1.
DR   Pfam; PF00351; Biopterin_H; 1.
DR   PRINTS; PR00372; FYWHYDRXLASE.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   2: Evidence at transcript level;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          1..198
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         151
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         156
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         196
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAM46840.1"
FT   NON_TER         198
FT                   /evidence="ECO:0000313|EMBL:AAM46840.1"
SQ   SEQUENCE   198 AA;  22623 MW;  0440ED8A3E9BABBA CRC64;
     VTKFDSDLDL DQPGFSDQAY RQRRKQIADI AFQYKHGSPI PRVEYTAEEI ATWKEVYSTL
     RGLYATHACR EYLQALELLE RCSGYSEDHI PQLEDVSRFL KERTGFQLRP VAGLLSARDF
     LASLAFRVFQ CTQYIRHASS TMHSPEPDCC HKLLGHVPML AERTFAQFSQ DIGLASLGAS
     DEAIEKLSTL YWFTVEFG
//