ID   CSW_DROSI      STANDARD;      PRT;   555 AA.
AC   Q8ISC9;
DT   15-SEP-2003 (Rel. 42, Created)
DT   15-SEP-2003 (Rel. 42, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Protein-tyrosine phosphatase corkscrew (EC 3.1.3.48) (Fragment).
GN   CSW.
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7240;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=SIM31;
RA   Riley R.M., Jin W., Gibson G.;
RT   "Contrasting selection pressures on components of the Ras-mediated
RT   signal transduction pathway in Drosophila.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required in all receptor tyrosine kinase signaling
CC       pathways. Functions downstream of the receptor tyrosine kinase
CC       torso, acting in concert with D-Raf via tailless. Also functions
CC       downstream of Egfr (epidermal growth factor receptor) and btl
CC       (fibroblast growth factor receptor). The SH2 domain suggests that
CC       csw effects its role by mediating heteromeric protein
CC       interactions. Maternally required for normal determination of cell
CC       fates at the termini of the embryo. Required for cell fate
CC       specification of the ventral ectoderm, in the developing embryonic
CC       CNS and for embryonic tracheal cell migration. Functions during
CC       imaginal development for proper formation of adult structures such
CC       as eyes, aristae, L5 wing vein and the tarsal claw (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- SIMILARITY: BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN-
CC       TYROSINE PHOSPHATASE FAMILY. SUBCLASS THAT CONTAINS SH2 DOMAINS.
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DR   EMBL; AY135142; AAN17645.1; -.
DR   FlyBase; FBgn0063985; Dsim\csw.
DR   InterPro; IPR003595; PTPc_motif.
DR   InterPro; IPR000387; TYR_phosphatase.
DR   InterPro; IPR000242; Tyr_PP.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
KW   Hydrolase; Developmental protein.
FT   NON_TER       1      1
FT   DOMAIN       85    355       PROTEIN-TYROSINE PHOSPHATASE.
FT   DOMAIN       11    103       PTPASE INSERT (CYS/SER-RICH).
FT   DOMAIN      447    481       ASN-RICH.
FT   ACT_SITE    293    293       BY SIMILARITY.
FT   DOMAIN      507    510       POLY-GLN.
SQ   SEQUENCE   555 AA;  59841 MW;  801534C03AE9DCFD CRC64;
     LPTDGDLYNM SSSSESLNSS VPSCPACTAA QTQRNCSNCQ LMNKTCVQCA VKSAILPYSN
     CATCSRKSDS LSKHKRSESS ASSSPSSGSG SGPGSSGTSG VSSVNGPGTP TNLTSGTAGC
     LAGLLKRHSN DSSGAVSISM AERERERERE MFKTYIATQG CLLTQQVNTV TDFWNMVWQE
     NTRVIVMTTK EYERGKEKCA RYWPDEGRSE QFGHARIQCV SENSTSDYTL REFLVSWRDQ
     PARRIFHYHF QVWPDHGVPA DPGCVLNFLQ DVNTRQSHLA QAGEKPGPIC VHCSAGIGRT
     GTFIVIDMIL DQIVRNGLDT EIDIQRTIQM VRSQRSGLVQ TEAQYKFVYY AVQHYIQTLI
     ARKRAEEQSL QVGREYTNIK YTGEIGNDSQ RSPLPPAISS ISLVPSKTPL TPTSADLGTG
     MGLSMGVGMG VGNKHASKQQ PPLPVVNCNN NNNGIGNSSC SNGGGSSNTS SSNGSSNGNI
     NALLGGIGLG LGGNMRKSNF YSDSLKQQQQ REEQAPAGAG KMQQPAPPLR PRPGILKLLT
     SPVIFQQNSK TFPKT
//