ID   Q8ILJ7_PLAF7            Unreviewed;      1148 AA.
AC   Q8ILJ7;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   02-SEP-2026, entry version 130.
DE   SubName: Full=Phosphoenolpyruvate carboxylase {ECO:0000313|EMBL:CZT99962.1};
DE            EC=4.1.1.31 {ECO:0000313|EMBL:CZT99962.1};
GN   ORFNames=PF3D7_1426700 {ECO:0000313|EMBL:CZT99962.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Laverania.
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99962.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|EMBL:CZT99962.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
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DR   EMBL; LN999946; CZT99962.1; -; Genomic_DNA.
DR   RefSeq; XP_001348420.1; XM_001348384.1.
DR   AlphaFoldDB; Q8ILJ7; -.
DR   SMR; Q8ILJ7; -.
DR   FunCoup; Q8ILJ7; 52.
DR   IntAct; Q8ILJ7; 1.
DR   STRING; 36329.Q8ILJ7; -.
DR   PaxDb; 36329-Q8ILJ7; -.
DR   GeneID; 811828; -.
DR   KEGG; pfa:PF3D7_1426700; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1426700; -.
DR   HOGENOM; CLU_006557_0_0_1; -.
DR   InParanoid; Q8ILJ7; -.
DR   OMA; VFGWTQS; -.
DR   OrthoDB; 1365747at2759; -.
DR   PhylomeDB; Q8ILJ7; -.
DR   Proteomes; UP000001450; Chromosome 14.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015977; P:carbon fixation; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 1.20.1440.90; Phosphoenolpyruvate/pyruvate domain; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_kinase-like_dom.
DR   PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   1: Evidence at protein level;
KW   Lyase {ECO:0000313|EMBL:CZT99962.1};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q8ILJ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   REGION          949..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        949..966
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        644
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10112"
SQ   SEQUENCE   1148 AA;  133960 MW;  F23AC584750321CA CRC64;
     MSNNHNNFIY CSGTEDDHVN NAETGGKEDE KLKFLIEGKM IEKKGCVDFI KPLKDDIKAL
     DFLLFDMLKD NLPNNLFEIL CTIHDLSETY SENPNDDNFL SLKNCIYNLK DEYLGTIVNA
     FGHMCVISNF AEWAHRGRRR KAFDKSFIPN DKIYGSVNET LKGTFNILIQ NGFQLNDIYE
     QLCNQTIEFV LTTHPTQAIR TSLLKNYIRL GELLLKLDNT DKELYKKKLL YDNLKTNLLS
     SWKTDVIRRI KPTPIDEAIS LVDIVENCIF YRIPNIIRYI DNVLFEYNLP PVKLNSKVCI
     FSSWAGGDRD GNPFVLPETT KYVCYMNKIR GCELFIPMIE ILIRDLTLHH CTQHFRSYVK
     LLEDEVSEYI FDKDHKYLAK KFQWFSPFSK SNKKEIYRRA LLIVWAKLKS VVEVYKSLIS
     NQRVDEDFKK LMFHNSDEFE EILLECYKSL VESGNTLIAE GYLKDVIRNV KIFGLHLMKL
     DIRQESEKHI STMNYICQKL NMKKYSLLNE EQKINFLTDI LNSNRPLIPK NIEEEEDVPN
     DFINVIKTFD VCSQIEDSAL GAYIVSMCTN ASDILLVEVF QKEMKKGTQR KTQRVVPLLE
     TIQSLQNSSI ILENLLKNPW YRKHLTTNFE DKQEIMIGYS DSGKDGGRLT SAWELFKAQE
     KLVHIGKKYS VEIRFFHGRG GSVSRGGGPQ HLAILSQPIN TIKNYLRVTI QGEVITQDFC
     LKGMALRSVE IYMSALLKCS LLKNTLVIKK EWRDLMDEIS EISTKEYRKV VYENKDFVKY
     FRCATPEIEI GKLNLGSRPS KRKEGNVESL RAIPWVFSWT QNRMHLSVWL GIEKIYDYLI
     NNNKLHIIQD MYTHWPFCTS FFNLISMVMA KASIQISQEY DILVPEELKY IGVLLREKLK
     KSMELTFLVT NEKKFCDNDQ LTKRSIECRT KWVTVCNLIQ IQALKRLREK ESKQKNENKD
     QLDNKDNSSY TNITHNYKIY ENTLVTPTSE YTNVENIKQD NNQLNNSMEN HNINDLNTLK
     INYTENYNFN KQNELFNNDE GKHMESINKN STVRINSYLS RKKKKLIKNP KFHPLIELHP
     YVFPQSETEN ESFFDYVKTI DSNFERIPSR NNVSTYDEAT NKFIDYTSLN DALIVSIKAI
     AAGMQNTG
//