Q8G6T9 PURA_BIFLO Adenylosuccinate synthetase AMPSase AdSS 6.3.4.4 IMP--aspartate ligase purA BL0549 Bifidobacterium longum (strain NCC 2705) Bacteria Bacillati Actinomycetota Actinomycetes Bifidobacteriales Bifidobacteriaceae Bifidobacterium NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] NCC 2705 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+) Mg(2+) Binds 1 Mg(2+) ion per subunit. Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Homodimer. Cytoplasm Belongs to the adenylosuccinate synthetase family. Cytoplasm GTP-binding Ligase Magnesium Metal-binding Nucleotide-binding Purine biosynthesis Reference proteome GTP IMP ligand shared between dimeric partners Mg(2+) IMP ligand shared between dimeric partners GTP Mg(2+) IMP ligand shared between dimeric partners IMP ligand shared between dimeric partners IMP ligand shared between dimeric partners IMP ligand shared between dimeric partners substrate IMP ligand shared between dimeric partners GTP GTP GTP MPGIVLIGAQWGDEGKGKATDLIGTKVDYVARFNGGNNAGHSVVVGDESYALHLLPSGIINPNLTPVIGNGVVVDPEVLFEEIDGLESRGIDCSHLKVSEAAHIIAPYHRTLDKVTERFLGKHKIGTTGRGIGPAYADKINRVGIRVHDLFNADHLHDKVEASLHQKNQMLVKLYNRRPIDVDQTTEELLKLGERLKPYVANTGLILNKALDEGKTVLFEGAQATMLDVDHGTYPFVTSSNPTAGGACTGTGVGPTRITRVVGVSKAYVTRVGEGPFPTELLDESGEWLRQQGHEFGVTTGRPRRCGWFDAVVNRYASQVNGLTDIVLTKLDVLAGLKEIPICVAYDVDGERHDDMPTDQAAFAAAKPIYETMPGWDEDISNCHSFDELPATCQAYVKRLEELSGCRISAIGTGPQRDHVIQINSLVD Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License