ID   Q8AXI4_GINCI            Unreviewed;       113 AA.
AC   Q8AXI4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   02-SEP-2026, entry version 70.
DE   SubName: Full=Novel antigen receptor {ECO:0000313|EMBL:AAN75852.1};
DE   Flags: Fragment;
OS   Ginglymostoma cirratum (Nurse shark) (Squalus cirratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes;
OC   Ginglymostomatidae; Ginglymostoma.
OX   NCBI_TaxID=7801 {ECO:0000313|EMBL:AAN75852.1};
RN   [1] {ECO:0000313|EMBL:AAN75852.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12909128; DOI=10.1016/S0161-5890(03)00084-1;
RA   Dooley H., Flajnik M.F., Porter A.J.;
RT   "Selection and characterization of naturally occurring single-domain
RT   (IgNAR) antibody fragments from immunized sharks by phage display.";
RL   Mol. Immunol. 40:25-33(2003).
RN   [2] {ECO:0007829|PDB:1SQ2, ECO:0007829|PDB:1T6V}
RP   X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS), AND DISULFIDE BONDS.
RX   PubMed=15319492; DOI=10.1126/science.1101148;
RA   Stanfield R.L., Dooley H., Flajnik M.F., Wilson I.A.;
RT   "Crystal structure of a shark single-domain antibody V region in complex
RT   with lysozyme.";
RL   Science 305:1770-1773(2004).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00114}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF447096; AAN75852.1; -; mRNA.
DR   PDB; 1SQ2; X-ray; 1.45 A; N=1-113.
DR   PDB; 1T6V; X-ray; 1.70 A; N/O=1-113.
DR   AlphaFoldDB; Q8AXI4; -.
DR   SMR; Q8AXI4; -.
DR   EvolutionaryTrace; Q8AXI4; -.
DR   GO; GO:0042605; F:peptide antigen binding; IEA:TreeGrafter.
DR   CDD; cd00099; IgV; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR051006; TCR_variable_domain.
DR   PANTHER; PTHR19343; T CELL RECEPTOR ALPHA VARIABLE 1-2; 1.
DR   PANTHER; PTHR19343:SF13; T CELL RECEPTOR ALPHA VARIABLE 21; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PDBsum; 1SQ2; -.
DR   PDBsum; 1T6V; -.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:1SQ2, ECO:0007829|PDB:1T6V};
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319, ECO:0000256|PROSITE-
KW   ProRule:PRU00114};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAN75852.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   T cell receptor {ECO:0000256|ARBA:ARBA00043266}.
FT   DOMAIN          1..83
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DISULFID        22..83
FT                   /evidence="ECO:0007829|PDB:1SQ2, ECO:0007829|PDB:1T6V"
FT   DISULFID        35..92
FT                   /evidence="ECO:0007829|PDB:1SQ2, ECO:0007829|PDB:1T6V"
FT   DISULFID        97..104
FT                   /evidence="ECO:0007829|PDB:1SQ2, ECO:0007829|PDB:1T6V"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAN75852.1"
FT   NON_TER         113
FT                   /evidence="ECO:0000313|EMBL:AAN75852.1"
SQ   SEQUENCE   113 AA;  12042 MW;  71522771FEA75661 CRC64;
     ARVDQTPRSV TKETGESLTI NCVLRDASYA LGSTCWYRKK SGEGNEESIS KGGRYVETVN
     SGSKSFSLRI NDLTVEDGGT YRCGLGVAGG YCDYALCSSR YAECGDGTAV TVN
//