Q86YT9 B0YIV1 B0YIV2 Q496M1 Q5DTC6 Q7Z499 Q8N9I7 Q8NF70 JAML_HUMAN Junctional adhesion molecule-like Adhesion molecule interacting with CXADR antigen 1 Dendritic cell-specific protein CREA7-1 JAML AMICA1 UNQ722/PRO1387 Homo sapiens Human Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) FUNCTION IN LEUKOCYTE MIGRATION INDUCTION SUBCELLULAR LOCATION DOMAIN TISSUE SPECIFICITY MUTAGENESIS OF LYS-54 VARIANT ALA-193 Bone marrow NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANTS ASN-94 AND ALA-193 Dendritic cell NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3) VARIANTS ASN-94 AND ALA-193 Cerebellum Spleen NUCLEOTIDE SEQUENCE [GENOMIC DNA] NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4) PROTEIN SEQUENCE OF 20-34 FUNCTION IN LEUKOCYTE MIGRATION INTERACTION WITH CXADR SUBCELLULAR LOCATION DOMAIN FUNCTION IN LEUKOCYTE MIGRATION HOMODIMERIZATION MUTAGENESIS OF LYS-54 INTERACTION WITH CXADR TISSUE SPECIFICITY FUNCTION IN LEUKOCYTE MIGRATION TISSUE SPECIFICITY Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Q86YT9 Q9NPF0 CD320 false 2 Q86YT9 P78310 CXADR false 2 Q86YT9-2 P21145 MAL false 3 Cell membrane Single-pass type I membrane protein Cell junction Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515). Q86YT9-1 1 Q86YT9-2 2 Q86YT9-3 3 Q86YT9-4 4 Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062). Belongs to the immunoglobulin superfamily. Extended N-terminus. Alternative splicing Cell adhesion Cell junction Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix MFCPLKLILLPVLL MVSG TL SI I N V A I M K E C G MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEGEKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQAF Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License