ID   Q83GL2_TROWT            Unreviewed;       339 AA.
AC   Q83GL2;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-OCT-2025, entry version 108.
DE   RecName: Full=[acyl-carrier-protein] S-malonyltransferase {ECO:0000256|ARBA:ARBA00013258};
DE            EC=2.3.1.39 {ECO:0000256|ARBA:ARBA00013258};
GN   Name=fabD {ECO:0000313|EMBL:AAO44351.1};
GN   OrderedLocusNames=TWT_254 {ECO:0000313|EMBL:AAO44351.1};
OS   Tropheryma whipplei (strain Twist) (Whipple's bacillus).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC   Tropherymataceae; Tropheryma.
OX   NCBI_TaxID=203267 {ECO:0000313|EMBL:AAO44351.1, ECO:0000313|Proteomes:UP000002200};
RN   [1] {ECO:0000313|EMBL:AAO44351.1, ECO:0000313|Proteomes:UP000002200}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Twist {ECO:0000313|EMBL:AAO44351.1,
RC   ECO:0000313|Proteomes:UP000002200};
RX   PubMed=12902375; DOI=10.1101/gr.1474603;
RA   Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M.,
RA   Claverie J.-M.;
RT   "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a
RT   reduced genome.";
RL   Genome Res. 13:1800-1809(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA;
CC         Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC         ChEBI:CHEBI:78449; EC=2.3.1.39;
CC         Evidence={ECO:0000256|ARBA:ARBA00048462};
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DR   EMBL; AE014184; AAO44351.1; -; Genomic_DNA.
DR   RefSeq; WP_011102456.1; NC_004572.3.
DR   AlphaFoldDB; Q83GL2; -.
DR   STRING; 203267.TWT_254; -.
DR   KEGG; twh:TWT_254; -.
DR   eggNOG; COG0331; Bacteria.
DR   HOGENOM; CLU_030558_1_2_11; -.
DR   OrthoDB; 3248271at2; -.
DR   Proteomes; UP000002200; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:TreeGrafter.
DR   Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase_dom.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR050858; Mal-CoA-ACP_Trans/PKS_FabD.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000313|EMBL:AAO44351.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002200};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAO44351.1}.
FT   DOMAIN          21..322
FT                   /note="Malonyl-CoA:ACP transacylase (MAT)"
FT                   /evidence="ECO:0000259|SMART:SM00827"
SQ   SEQUENCE   339 AA;  37499 MW;  CC16D7A90F5A2952 CRC64;
     MASICDTTPE ECAAAGNAVI TCPGQGAQKS GLLNEWLDLP GSLEFFQAQS DFLKIDLIKH
     GTISDTDILR DTRIAQPLIV ALGIFVIRTL QQKAKIIQSM PEEGLNGANP TERIMRCVGL
     AGHSVGEITA AFGAGVLTEK NAMRLVKHRA NQMYKSTQIF DTGMVAVLGQ SENLEEYITQ
     RYKLFPANYN CPGQIVFAGL RENLDVLLAN PPEKIKVIPL QVAGAFHTRF MRPAVQNLKK
     LKFVTDKSFA KDPDKRIWTN YDGSEIFSGS EYVQLLIDQI ARPVRWDLCQ KNFENIDYLI
     ELPPAGTLTG LARRSLPKVK GIPINTIDDL EEASCCFLL
//