ID   Q82NB2_STRAW            Unreviewed;       853 AA.
AC   Q82NB2;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   04-NOV-2026, entry version 125.
DE   SubName: Full=Magnesium or manganese-dependent protein phosphatase {ECO:0000313|EMBL:BAC69101.1};
GN   Name=prpJ5 {ECO:0000313|EMBL:BAC69101.1};
GN   ORFNames=SAVERM_1391 {ECO:0000313|EMBL:BAC69101.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC69101.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC69101.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC69101.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
RN   [3] {ECO:0000313|EMBL:BAC69101.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=23990133; DOI=10.1007/s10295-013-1327-x;
RA   Ikeda H., Shin-ya K., Omura S.;
RT   "Genome mining of the Streptomyces avermitilis genome and development of
RT   genome-minimized hosts for heterologous expression of biosynthetic gene
RT   clusters.";
RL   J. Ind. Microbiol. Biotechnol. 41:233-250(2014).
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DR   EMBL; BA000030; BAC69101.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q82NB2; -.
DR   KEGG; sma:SAVERM_1391; -.
DR   eggNOG; COG2203; Bacteria.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_000445_43_3_11; -.
DR   OMA; ADWCIVT; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016791; F:phosphatase activity; IEA:TreeGrafter.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   CDD; cd00130; PAS; 2.
DR   FunFam; 3.30.450.40:FF:000035; PAS sensor protein; 1.
DR   FunFam; 3.30.565.10:FF:000028; PAS sensor protein; 1.
DR   FunFam; 3.60.40.10:FF:000031; PAS sensor protein; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR052016; Bact_Sigma-Reg.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR003594; HATPase_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR43156:SF2; STAGE II SPORULATION PROTEIN E; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF13185; GAF_2; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00091; PAS; 2.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT   DOMAIN          69..107
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
SQ   SEQUENCE   853 AA;  92007 MW;  89B133183D695E07 CRC64;
     MASAWSPTRR GSRERPTRVR VTTVAGRVRR TGVDDIGIRY EVVSGVEKRM TVLSESGDDP
     FALHHAASVV LDDRGTVVGW SRRAQELLGY PESAVIGRPA FDVLIDPGSL PAAKDAAATC
     RRDGGWFGVL AVRHSSGRLV EMGFRARALL RGDHVREWFL VGAPAAEVLE WQRDRAVLDG
     LFRRCPIGLV VHSPELTILR VNRAIERFTG IPAASFRGMP TGALLVAEDA RTSVDRVRQV
     VETGRSQVST EQYARLERDP ARVRAASVSA FRLEDPAGRV LGVAETVEDV TERHRARLRL
     ALLNQAGARI GSTLDVRETA RELADVMVPH LADHVSVDLS PPVMRGEEPA QAPTGPVARV
     AVRGVVARQP DLEYPEGEPV QFAPGTPQAG CLADGRPVLE PVLSPDWFLA EPRQGEHAPD
     LSAHSLIVVP LAARGLVLGV MSLWRSRHPE PFEPDDLTLA QELASRAAVS IDNARRFTQQ
     QQTASTLQRT LLPRTVPHQP AVEVAPRYLP ASTASGPGGD WFDVIPLSGA RVALVVGDVV
     GHGLHAAATM GRLRTAVHTL ATLDLEPDEV LSRLDDLVNL LAAEQETAGE GPAGEQIVGA
     TCLYAVYDPV SRQCSAARAG HPLPVVTTPD GQAGLLDLPP GPPLGLGGLP FEAREIELAE
     GSLLTLYTNG LIGERHIDVD TGLQRLRTAL THPADPLEKT CQAVVDSLVP AQPADDIALL
     IARTRVLPPE NVASWQLPLE PTAAAQARAL ATAQLSQWGL EHLAFTTELI ASELVTNAYR
     YAGGPVTLRL IRERCLVCEV ADASHTSPHL RRARTTDEGG RGLFLVAQMT ERWGTRYSRE
     GKTVWTEQPL LGL
//